INTRODUCTION
MUCOBRINT SYRUP is a combination of Acebrophylline, Guaiphenesin and Terbutaline which belongs to the group of medicines called Bronchodilators, Expectorants and Beta agonists respectively. MUCOBRINT SYRUP is used to treat cough with mucus. A cough with severe mucus production,?can sometimes occur in response to irritation from an allergen or irritant. The most common causes include smoke, air pollution, and pollen. Sometimes, a cough that produces mucus can be an alert for an acute health condition, such as an upper or lower respiratory infection.
Before taking MUCOBRINT SYRUP inform your doctor if you if you have diabetes, fits, hypotension (low blood pressure), overactive thyroid, hypokalaemia (low potassium levels in the blood), stomach ulcers, phenylketonuria, arrhythmias (abnormal heart beats), and kidney, liver, or heart problems. Do not take MUCOBRINT SYRUP if you are allergic to Acebrophylline, Guaiphenesin, Terbutaline or any other ingredients of this medicine.
MUCOBRINT SYRUP should be used with caution in pregnant, breastfeeding women, and elderly patients. Your doctor will prescribe the right dose depends on your child?s age, body weight and disease condition. Consult your doctor before taking MUCOBRINT SYRUP. The common side effects of MUCOBRINT SYRUP are tremor (shaky hands), headache, tachycardia (heat beats faster), palpitations (feeling aware of your heartbeat) and muscle spasms. Consult your doctor if you feel any of these side effects worsen or persists for a longer duration.

USES OF MUCOBRINT SYRUP

Used to treat cough with mucus

HOW MUCOBRINT SYRUP WORKS
MUCOBRINT SYRUP is a combination of Acebrophylline, Guaiphenesin and Terbutaline. Acebrophylline lowers the viscosity of the thick mucus and increases ciliary motility making it easy for mucus to be moved. It facilitates bronchial muscles relaxation by increasing certain enzymes. Guaiphenesin increases respiratory tract fluid, reduces the viscosity of tenacious secretions and acts as an expectorant. Terbutaline works by relaxing the muscles in the airways and widens airways. When the medicine is given in combination, it makes breathing easier and relives the discomfort.

DIRECTIONS FOR USE
Take MUCOBRINT SYRUP as advised by your physician. Shake well before use.?Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF MUCOBRINT SYRUP

COMMON

Tremors
Nausea, vomiting
Pain in the upper part of abdomen
Diarrhoea
Elevation in liver enzymes
Nervousness
Headache
Palpitations
Shortness of breath
Anxiety
Muscle cramps
Dry mouth or throat
Dysgeusia (change in taste)

RARE

Hypersensitivity reactions
Heart related symptoms (atrial fibrillation, supraventricular tachycardia and extra systoles, myocardial ischaemia, peripheral vasodilation)
Hallucinations (seeing or hearing something that is not there)
Paraesthesia (an abnormal sensation)

Stop taking MUCOBRINT SYRUP and contact your doctor immediately if you experience any of the following side effects:

Serious allergic reactions that may cause swelling of face or throat, wheezing or sudden difficulties in breathing
Skin lesions such as severe blistering or peeling of your skin, mouth, throat, nose, eyes, and genitals
Uncontrollable shaking
Nervousness
Dizziness, drowsiness
Difficulty falling asleep or staying asleep
Weakness
Sweating
Feel tightness of your chest
Signs of pruritus

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.

Nausea And Vomiting

Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.

Stomach Pain

Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.

WARNING & PRECAUTIONS

PREGNANCY
USE WITH CAUTION

MUCOBRINT SYRUP should be used with caution during pregnancy. Consult your doctor for advice.

BREASTFEEDING
USE WITH CAUTION

MUCOBRINT SYRUP should be used with caution during breastfeeding. Consult your doctor for advice.

DRIVING AND USING MACHINES
USE WITH CAUTION

MUCOBRINT SYRUP does not influence the capacity of?driving or operating any machines. Consult your doctor for advice.

KIDNEY
USE WITH CAUTION

MUCOBRINT SYRUP should be used with caution in patients with kidney diseases. Consult your doctor for advice.

LIVER
USE WITH CAUTION

MUCOBRINT SYRUP should be used with caution in patients with liver diseases. Consult your doctor for advice.

ALLERGY
CONTRAINDICATED

Do not take MUCOBRINT SYRUP if you are allergic to Acebrophylline, Guaiphenesin, Terbutaline or any other ingredients of this medicine.

HEART DISEASE
USE WITH CAUTION

MUCOBRINT SYRUP should be used with caution in patients with heart diseases. Consult your doctor for advice.

USE IN PEDIATRICS
CONSULT YOUR DOCTOR

Your doctor will prescribe the right dose depends on your child?s age, body weight and disease condition. Consult your doctor before giving MUCOBRINT SYRUP.

USE IN GERIATRICS
USE WITH CAUTION

MUCOBRINT SYRUP should be used with caution in elderly patients. Consult your doctor for advice.

OTHERS
MUCOBRINT SYRUP is not recommended for use if you:

Have peptic ulcers

Before taking MUCOBRINT SYRUP, inform your doctor if you:

Have intolerance to fructose
Have a history of fits or seizures
Have thyroid problems
Have hypertension

INTERACTIONS
A. Drug-Drug interactions:
Before taking MUCOBRINT SYRUP, inform your doctor if you are taking any of the following medicine:

Beta-blocking agents used to treat hypertension (Ex. propranolol)
Diuretics (Ex. spironolactone)
Monoamine oxidase inhibitors to treat depression (Ex. isocarboxazid)
Methyl xanthine (Ex. aminophylline)
Corticosteroids to treat severe infections (Ex. deflazacort)
Antibiotics to treat infections. (Ex. ampicillin, amoxicillin, erythromycin)

Overdosage:
If you or anyone else accidentally takes too much of MUCOBRINT SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are abdominal pain, agitation, palpitations, seizures/fits, increased heartbeat, nervousness, headache, tremor, dry mouth, nausea, vomiting, dizziness, fatigue, malaise, insomnia (sleeplessness).

SYNOPSIS

Drug
:
Acebrophylline, Guaiphenesin, Terbutaline

Pharmacological Category
:
Bronchodilators, Expectorants, Beta agonists

Therapeutic Indication
:
Treats cough with mucus

Dosage Forms
:
Tablet, Syrup

MORE INFORMATION

Keep MUCOBRINT SYRUP out of reach of children
Store at room temperature

FAQs ABOUT MUCOBRINT SYRUP
Q: What is MUCOBRINT SYRUP used for?
A: MUCOBRINT SYRUP is used to treat cough with mucus. A cough with severe mucus production,?can sometimes occur in response to irritation from an allergen or irritant. The most common causes include smoke, air pollution, and pollen. Sometimes, a cough that produces mucus can be an alert for an acute health condition, such as an upper or lower respiratory infection.
Q: How is MUCOBRINT SYRUP useful in treating severe cough?
A: Acebrophylline lowers the viscosity of the thick mucus and increases ciliary motility making it easy for mucus to be moved. Acebrophylline?facilitates bronchial muscles relaxation by increasing certain enzymes. Guaiphenesin increases respiratory tract fluid, reduces the viscosity of tenacious secretions and acts as an expectorant. Terbutaline predominantly stimulates beta?2-receptors (these are a kind of receptors present in airway smooth muscles) thus producing relaxation of bronchial smooth muscle. When the medicine is given in combination, it makes breathing easier and relives the discomfort.
Q: How to use MUCOBRINT SYRUP?
A: Take MUCOBRINT SYRUP as advised by your physician. Shake well before use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Q: What are the side effects seen with MUCOBRINT SYRUP?
A: Like any other medicines MUCOBRINT SYRUP also has few side effects like tremor, feeling sick (nausea) or being sick (vomiting), pain in the upper part of your abdomen, diarrhoea, elevation in liver enzymes, nervousness, dizziness and drowsiness, headache, anxiety, palpitation, rapid heart rate, shortness of breath, chest discomfort, weakness, flushed feeling and sweating, anxiety, muscle cramps, dry mouth, dry throat, dysgeusia (changed taste). Consult your doctor if you experience these side effects.
Q:?Will MUCOBRINT SYRUP be more effective if taken in more than recommended doses?
A: No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms, that are not relieved by the recommended doses, consult your doctor for re-evaluation.

REFERENCES
1. KD. Tripathi. Drugs for Cough and Bronchial Asthma. Chapter 16 Essentials of medical pharmacology. Seventh edition. 2017.
2. Fuller RW, Jackson DM. Physiology and treatment of cough. June 1990. [Accessed on 12th July 2022]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC462522/?page=13
3. AstraZeneca. Acebrophylline + Guaiphenesin +Terbutaline. [Revised in Sep 2020] [Accessed on 12th July 2022]?https://www.medicines.org.uk/emc/files/pil.59.pdf
4. Delpharm Acebrophylline + Guaiphenesin +Terbutaline. [Revised in July 2021] [Accessed on 12th July 2022]?https://www.medicines.org.uk/emc/files/pil.1479.pdf
5. Cipla med Acebrophylline + Guaiphenesin +Terbutaline. [Revised in November 2013] [Accessed on 12th July 2022]?https://www.ciplamed.com/content/mucophylin-capsules

AUTHOR DETAILS
Written By Dr. Janet.C, Pharm.D

Last updated on 13 Mar 2023 | 10:42 AM(IST)

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