Specification

INTRODUCTION
ESCOT CREAM is a combination of Lignocaine and Nifedipine, which belongs to theroup of medicines called Local anaesthetics and Calcium channel blockers. It is used to relieve pain and relax muscles during the treatment or examination of anal fissures, thrombosed external haemorrhoids, post-haemorrhoidectomy, anal sphincter hypertonia, etc.
An anal fissure is a small cut or tear in the delicate lining of the anus that occurs when passing hard or large stools, causing pain and bleeding during bowel movements. Sometimes the pain caused by the anal fissure leads to contraction of the muscle that controls bowel movements and frequent bowel movements.
Before applying ESCOT CREAM, inform your doctor if you have severely injured mucosa, inflammation of the areas in the rectum, diabetes, liver or kidney cardiac insufficiency, etc. Pregnant (especially during the first trimester) and breastfeeding women should use ESCOT CREAM with caution.
ESCOT CREAM is not recommended for use in children and adolescents (below 18 years of age) and should be used with caution in elderly patients. Consult your doctor before applying. The common side effects of ESCOT CREAM are pain, burning sensations, itching, hyperemia and bleeding. Consult your doctor if any of the symptoms worsen.
USES OF ESCOT CREAM

Relieves pain and relaxes muscles during the treatment or examination of anal fissure, thrombosed external haemorrhoids, post haemorrhoidectomy, anal sphincter hypertonia

HOW ESCOT CREAM WORKS
Lignocaine is a local anaesthetic that numbs the area where you have applied it by stopping nerves from sending pain signals to the brain. Nifedipine is a calcium channel blocker that relaxes the muscles in the anal opening. This collective action is useful for relieving pain and healing anal fissures.
DIRECTIONS FOR USE
Apply ESCOT CREAM as advised by your physician. It is for rectal use only. Wash your hands before use and if possible, use a finger covering, such as a plastic wrap, cling film, a finger cot or a disposablelove. Apply the medicine to the anal region as advised by your doctor. Your doctor will determine the correct dose and duration of treatment for you based on your age and the severity of your existing condition.
SIDE EFFECTS OF ESCOT CREAM

COMMON

Pain

Burning sensation

Itching

Hyperaemia

Bleeding

HOW TO MANAGE SIDE EFFECTS
Itching:
Wash the area around the anus carefully daily with plain water or mild soap to keep it clean and dry. Avoid irritants and do not wear tight underwear. If there is no improvement, please consult your doctor for advice.
Pain:
Try to have a warm bath after a bowel movement. Maintain a high-fiber diet and use stool softeners as advised by your doctor. Drink more water. If there is no improvement, please consult your doctor for advice.
WARNING & PRECAUTIONS

PREGNANCY
ESCOT CREAM should be used with caution in pregnant women (especially during the first trimester). Consult your doctor before applying it.
BREASTFEEDING
ESCOT CREAM should be used with caution in breastfeeding women. Consult your doctor before applying it.
DRIVING AND USING MACHINES
No effects that could influence the capacity to drive and operate machinery are therefore foreseeable.
KIDNEY
ESCOT CREAM should be used with caution in patients with renal insufficiency. Consult your doctor before applying it.
LIVER
ESCOT CREAM should be used with caution in patients with hepatic insufficiency. Consult your doctor before applying it.
ALLERGY
Do not apply ESCOT CREAM if you are allergic to Lidocaine or Nifedipine.
HEART DISEASE
ESCOT CREAM is not recommended for use in patients with cardiac insufficiency. Consult your doctor before applying it.
OTHERS
ESCOT CREAM is not recommended for use if you:
Have severe hypotension
Before applying ESCOT CREAM, inform your doctor if you:
Have severely injured mucosa and phlogosis (inflammation)

Have diabetes
Use in Pediatrics:
ESCOT CREAM is not recommended for use in children and adolescents (below 18 years of age). Consult your doctor before applying it.
Use ineriatrics:
ESCOT CREAM should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before applying it.
INTERACTIONS
A. Drug-Drug interactions:
Before applying ESCOT CREAM, inform your doctor if you are taking any of the following medicine:
Medicines used to lower blood pressure [Ex. propranolol]

Cimetidine (a medicine used to treat stomach acidity and peptic ulcers)

Digoxin (a medicine used to treat heart problems)
Overdosage:
If you or anyone else have accidentally applied too much of ESCOT CREAM, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are light-headedness, dizziness, ringing sensation in the ears, decrease in blood pressure, altered heart rate, etc.
SYNOPSIS

Drug :?? Lignocaine (Lidocaine), Nifedipine

Pharmacological Category :?? Local anaesthetics, Calcium channel blockers

Therapeutic Indication :?? Relieves pain and relaxes muscles during the treatment or?examination of anal fissure, thrombosed external haemorrhoids, post haemorrhoidectomy,?anal sphincter hypertonia

Dosage Forms :?? Cream,el

MORE INFORMATION

Keep ESCOT CREAM out of reach from children

Store at room temperature

FAQs ABOUT ESCOT CREAM
What are the precautions to be followed while applying ESCOT CREAM?
ESCOT CREAM for rectal use should be used with caution in patients with severely injured mucosa and phlogosis (inflammation), diabetic patients or those with hepatic and/or renal insufficiency, elderly patients or in patients being treated with antihypertensive drugs. If your symptoms worsen, please contact your doctor immediately.
Can we apply ESCOT CREAM for pregnant women?
In pregnant women (especially during the first trimester), ESCOT CREAM should be used with caution. Consult your doctor before applying ESCOT CREAM.
Can spicy food cause fissures?
No. Spicy foods do not cause fissures. But they can irritate the fissures and worsen your symptoms. Therefore, it is advised that you avoid spicy foods if you are facing issues with your fissures.
How long does the fissure take to heal?
Fissures usually heal within a few weeks. But if they persist for longer than 4 to 6 weeks, they are termed chronic fissures. Please consult your doctor without delay if you have been noticing fissures for longer than 4 weeks.
REFERENCES
1. KD Tripathi. Antiarrhythmic Drugs & Antianginal and Other Anti-ischaemic Drugs. Essentials of medical pharmacology. Seventh 7th edition. 2013. Page ? 530 & 549.
2. Rasha Kadim Albayati, Adel Musa Al-Rekabi, Nahedh R. Alammar, Adel Musa Al-Rekabi. Topical combination of Nifedipine with Lidocaine for Anal Fissure Treatment, Indian Journal of Public Health Research and Development, March 2019. [Accessed on 8th June 2022] https://www.researchgate.net/profile/Hayder-Fawzi/publication/331625528_Topical_Combination_of_Nifedipine_with_Lidocaine_for_Anal_Fissure_Treatment/links/5c8830f9a6fdcc38174f9438/Topical-Combination-of-Nifedipine-with-Lidocaine-for-Anal-Fissure-Treatment.pdf
3. Pasquale Perrotti, Patrizia Dominici, Enzorossi, Carmine Antropoli,uglielmoiannotti, Maria Cusato, Mario Regazzi, Renata Cerutti. NIH National Library of Medicine, National center for Biotechnology Information. Pharmacokinetics of anorectal nifedipine and lidocaine (lignocaine) ointment following haemorrhoidectomy: an open-label, single-dose, phase IV clinical study, 2009. [Accessed on 8th June 2022] https://pubmed.ncbi.nlm.nih.gov/19301938/
4. NEW FA DEM Farmaceutici e Chimici S.r.l., Lignocaine and Nifedipine. [Revised in June 2020] [Accessed on 8th June 2022] https://myhealthbox.eu/en/view/3527457/e00dfb867aba2b7b0df8d941eba051ac/leaflet
PRODUCT DETAILS

Net Qty

1 N

Item Weight

40

Ingredient

LIDOCAINE 1.5% NIFEDIPINE 0.3%

Hsn Code

30049069

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Additional information

Weight
40 g

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