Ranolaz OD Tablet 10?S Allschoolabs -

Specification

Ranolaz OD Tablet 10?S

?Ranolazine 1000 mg

INTRODUCTION:-
RANOLAZ OD TABLET contains Ranolazine which belongs to theroup of medicines called Antianginals. It is used to treat chronic angina.
Angina pectoris can be defined as a sudden, sharp and severe chest pain that originates from the apex of the heart and radiates to the left shoulder. It can be characterized by the presence of severe and crushing pain along with a feeling of pressure and suffocation, especially behind the breastbone.
RANOLAZ OD TABLET is not recommended for use in patients with severe kidney disease, moderate to severe liver disease. Contact your doctor before taking.
RANOLAZ OD TABLET should be used with caution in patients with mild to moderate kidney disease, mild liver disease and moderate to severe heart failure, abnormal ECG changes like like QT prolongation or long QT syndrome. Contact your doctor before taking.
RANOLAZ OD TABLET isenerally not recommended for use in pregnant women unless considered clearly necessary. Contact your doctor before taking. RANOLAZ OD TABLET is not recommended for use in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before taking it.
RANOLAZ OD TABLET is not recommended for use in children and adolescents under 18 years of age. Contact your doctor before taking.
RANOLAZ OD TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking.
Avoid drinkingrapefruit juice as it may lead to unwanted effects. The most common side effects of taking RANOLAZ OD TABLET are nausea, vomiting, constipation, dizziness headache and weakness. Contact your doctor if any of the above side effects worsen.
USES OF RANOLAZ OD TABLET:-
Used to treat chronic angina
HOW RANOLAZ OD TABLET WORKS:-
RANOLAZ OD TABLET works by inhibiting the entry of sodium and potassium into the heart cells, thereby preventing the calcium influx causing vasodilation and reduces ventricular tension, myocardial oxygen demand. Thus, relieving angina symptoms.
DIRECTIONS FOR USE:-
Take RANOLAZ OD TABLET as advised by your physician. Swallow the medicine with alass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF RANOLAZ OD TABLET:-

COMMON

Nausea, vomiting

Constipation

Dizziness

Headache

Weakness

UNCOMMON

Altered sensation

Anxiety

Difficulty sleeping

Confusion

Hallucination

Blurred vision, visual disturbance

Changes in sensation (touch or taste)

Tremors

Feeling tired or sluggish

Sleepiness or drowsiness

Fainting

Dark urine, blood in urine, difficulty in urination

Difficulty in breathing

Cough, nose bleed

Excessive sweating, itching

Feeling swollen or bloated

Hot flushes, low blood pressure

Increase in creatinine

Increase in urea in blood

Increase in blood platelets count and white blood cells

Changes in ECG heart tracing

Joint swelling, pain in extremity

Loss of appetite and/or weight loss

Muscle cramp or weakness

Ringing in the ears or spinning sensation

Stomach pain, discomfort, indigestion

Dry mouth

RARE

Paraesthesia in mouth and lips

Rashes

Problems with coordination

Decrease in blood pressure upon standing

Disorientation

Coldness in hands and legs

Hives, allergic skin reaction

Impotence

Inability to walk due to imbalance

Inflammation of pancreas or intestine

Loss of memory

Throat tightness

Low sodium levels in the blood (hyponatremia) causing tiredness, confusion, muscle twitching, cramps
Stop taking RANOLAZ OD TABLET and contact your doctor immediately if you experience any of the following side effects:
Symptoms of angioedema or allergic reaction such as hives, swelling of the face, tongue or throat causing difficulty in breathing or swallowing
HOW TO MANAGE SIDE EFFECTS:-

Headache:

Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.

Nausea and Vomiting:

Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food.

Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals. Drink plenty of water and exercise more regularly.

Dizziness:

Try to rest and relax.et enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.
WARNING & PRECAUTIONS:-

PREGNANCY

RANOLAZ OD TABLET is not recommended for use in pregnant women unless considered clearly necessary. Contact your doctor before taking RANOLAZ OD TABLET.

BREASTFEEDING

RANOLAZ OD TABLET is not recommended for use in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before taking RANOLAZ OD TABLET.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizziness, lightheadedness, faintness, blurred vision, confusion, hallucination, double vision and coordination problems after taking RANOLAZ OD TABLET.

KIDNEY

RANOLAZ OD TABLET is not recommended for use in patients with severe kidney disease and should be used with caution in mild to moderate kidney disease. Contact your doctor before taking RANOLAZ OD TABLET.

LIVER

RANOLAZ OD TABLET is not recommended for use in patients with moderate to severe liver disease and should be used with caution in mild liver disease. Contact your doctor before taking RANOLAZ OD TABLET.

ALLERGY

Do not take RANOLAZ OD TABLET if you are allergic to Ranolazine or to lactose or other sugars or to any other ingredients of this medicine.

HEART DISEASE

RANOLAZ OD TABLET should be used with caution in patients with moderate to severe heart failure, abnormal ECG changes like QT prolongation or long QT syndrome. Contact your doctor before taking RANOLAZ OD TABLET.
OTHERS:-
RANOLAZ OD TABLET is not recommended for use if you have:
Rare hereditary problems likealactose intolerance, the Lapp lactase deficiency andlucose-galactose malabsorption

Use in pediatrics:

RANOLAZ OD TABLET is not recommended for use in children and adolescents under 18 years of age. Contact your doctor before taking RANOLAZ OD TABLET.

Use ineriatrics:

RANOLAZ OD TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking RANOLAZ OD TABLET.
INTERACTIONS:-

A. Drug ? Drug interactions:

Before taking RANOLAZ OD TABLET, inform your doctor if you are taking any of the following medicine:
Medicines used to treat bacterial infections (Ex. clarithromycin, telithromycin, erythromycin)

Medicines used to treat fungal infections (Ex. itraconazole, ketoconazole, fluconazole, voriconazole, posaconazole)

Medicines used to treat HIV infection (atazanavir, nelfinavir, ritonavir, indinavir, saquinavir tenofovir disoproxil and efavirenz)

Nefazodone (used for depression)

Medicines used to treat heart problems or heart rhythm disorders (Ex. quinidine, dofetilide, sotalol, metoprolol, diltiazem, verapamil, procainamide, disopyramide)

Medicine used to prevent rejection of a transplanted organ (cyclosporine, tacrolimus, sirolimus, everolimus)

Medicines used to treat epilepsy (Ex. phenytoin, carbamazepine or phenobarbital)

Medicines used to treat tuberculosis (Ex. rifampicin, rifampin, rifabutin, rifapentine)

St. John?s Wort (herbal medicine used for depression)

Digoxin (medicines used for heart failure)

Medicines used to treat allergies (Ex. terfenadine, astemizole, mizolastine)

Medicines to treat psychoses (Ex. bupropion, imipramine, doxepin, amitriptyline, paroxetine)

Medicines used to treat cancer (Ex. cyclophosphamide)

Medicines to treat elevated cholesterol levels in the blood (Ex. simvastatin, lovastatin, atorvastatin)

Cimetidine (medicine used for stomach ulcers)

Metformin (medicines used to treat diabetes mellitus)

B. Drug ? Food interaction:

Avoid drinkingrapefruit juice with this medicine as it may lead to unwanted effects. Consult your doctor for advice.
Overdosage:
If you or anyone else accidentally takes too much of RANOLAZ OD TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are dizziness, nausea and vomiting.
SYNOPSIS:-
Drug :?? Ranolzine

Pharmacological Category :?? Antianginals

Therapeutic Indication :?? Chronic angina

Dosage Forms :?? Tablet
MORE INFORMATION:-
Keep RANOLAZ OD TABLET out of the sight and reach of children

Store RANOLAZ OD TABLET below 25?C
FAQs ABOUT RANOLAZ OD TABLET:-
Who should avoid taking RANOLAZ OD TABLET?
RANOLAZ OD TABLET is not recommended for use in patients with allergic history to Ranolazine or lactose or rare hereditary problems likealactose intolerance, the Lapp lactase deficiency andlucose-galactose malabsorption, severe kidney disease, moderate to severe liver disease. Contact your doctor before taking RANOLAZ OD TABLET.
How RANOLAZ OD TABLET works?
RANOLAZ OD TABLET works by inhibiting the entry of sodium and potassium into the heart cells, thereby preventing the calcium influx causing vasodilation and reduces ventricular tension, myocardial oxygen demand. Thus, relieving angina symptoms.
What are the side effects of taking RANOLAZ OD TABLET?
The most common side effects of taking RANOLAZ OD TABLET are nausea, vomiting, constipation, dizziness headache and feeling weak. Contact your doctor if any of the symptoms worsen.
Does RANOLAZ OD TABLET cause hyponatremia?
Yes. RANOLAZ OD TABLET may cause hyponatremia. Contact your doctor if you experience any unusual symptoms like tiredness, confusion, muscle twitching, cramps.
Can I takerapefruit juice while taking RANOLAZ OD TABLET?
No. Avoid drinkingrapefruit juice with this medicine as it may lead to unwanted effects. Contact your doctor before taking.
REFERENCES:-
1. KD. Tripathi. Cardiovascular drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page -554.
2. Robert J. Kizior, Keith J. Hodgson. Ranolazine. Saunders Nursing Drug Handbook 2021. 28th edition. 2021. page-1000.
3. Menarini. Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised on December 2021] [Accessed on 4th June 2022]?https://www.medicines.org.uk/emc/files/pil.6442.pdf
4.ilead Sciences, Inc. U.S. Food & Drug Administration. [Revised on January 2016] [Accessed on 4th June 2022]?https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021526s029lbl.pdf
5.ilead Sciences, Inc. Ranolazine. [Revised on April 2010] [Accessed on 4th June 2022]?https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d442b8c-97a8-40a9-8603-f9cd0542cedc
6. Ranolazine. Torrent Pharmaceuticals ltd. [Revised on July 2019] [Accessed on 4th June 2022]?https://www.torrentian.com/pisheet/Upload/PI_Sheet/1344.pdf
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