CYCLOMARK Tablet 10?s Allschoolabs -

Specification

INTRODUCTION
CYCLOMARK TABLET is a combination of Dicyclomine and Paracetamol which belongs to the group of medicines called Antispasmodics and Analgesics, respectively. CYCLOMARK TABLET is used to provide relief from spasmodic pain and discomfort due to biliary colic (abdominal pain), intestinal colic (intestinal pain), renal colic (sharp pain due to kidney dysfunction), and spasmodic dysmenorrhea (sharp pelvic pain at the start of menstrual flow) in affected individuals.
CYCLOMARK TABLET is also used to provide relief from the symptoms of irritable bowel syndrome (IBS) and functional bowel disease.
CYCLOMARK TABLET is not recommended for use in patients allergic to dicyclomine, and paracetamol. It is also not recommended for use in patients with liver problems such as severe hepatic insufficiency and in patients with a history of known idiosyncrasy (adverse effect) to dicyclomine.
Before taking CYCLOMARK TABLET, inform your doctor if you have/ suspected of having glaucoma (increased eye pressure), prostatic hypertrophy (prostate gland enlargement), Gilbert?s syndrome (inherited liver disorder), liver problems (such as mild to moderate hepatic insufficiency), and/or kidney problems (such as severe renal insufficiency).
CYCLOMARK TABLET should be used with caution in pregnant and breastfeeding women only if it is clearly necessary. CYCLOMARK TABLET is not recommended for use in children & adolescents (aged below 12 years) and in elderly patients. Consult your doctor before taking CYCLOMARK TABLET.
The most common side effects of taking CYCLOMARK TABLET are hypersensitivity reaction (immune mediated reaction), dry mouth, stomach upset, bloating, flatulence, vomiting, and/or constipation. Consult your doctor if any of these symptoms worsens.
USES OF CYCLOMARK TABLET

Provides relief from spasmodic pain and discomfort due to biliary colic, intestinal colic, renal colic and spasmodic dysmenorrhea

Provides relief from the symptoms of irritable bowel syndrome (IBS) and functional bowel disease

HOW CYCLOMARK TABLET WORKS
CYCLOMARK TABLET provides relief from spasmodic pain and discomfort, where Dicyclomine relieves abdominal cramps, pain, bloating and discomfort by relaxing the muscles in the stomach & gut and preventing the occurrence of sudden muscle contractions and Paracetamol provides relief from pain by blocking the action of prostaglandin (chemical messengers responsible for pain) thus providing reducing spasmodic pain and discomfort in affected individuals.
DIRECTIONS FOR USE
Take CYCLOMARK TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF CYCLOMARK TABLET

COMMON

Signs of hypersensitivity reaction (immune mediated reaction) such as red itchy welts, fever, itching, shortness of breath, wheezing, and/or runny nose

Dry mouth

Stomach upset, bloating, flatulence, vomiting, constipation

RARE
Stop taking CYCLOMARK TABLET and contact your physician immediately if you experience any of the following side effects:
Serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis associated with symptoms such as progressive skin rash, blisters, and/or mucosal lesions

HOW TO MANAGE SIDE EFFECTS
Dry mouth:
Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and use mouthwash. Consult and inform your doctor if the symptom gets worse.
Vomiting:
Take CYCLOMARK TABLET with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.
Constipation:
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate treatments for constipation.
WARNING & PRECAUTIONS

PREGNANCY
CYCLOMARK TABLET should be used with caution during pregnancy only if it is clearly necessary. Consult your doctor before taking CYCLOMARK TABLET.
BREASTFEEDING
CYCLOMARK TABLET should be used with caution in breastfeeding women only if it is clearly necessary since the medicine may get excreted in breast milk. Consult your doctor before taking the medicine.
DRIVING AND USING MACHINES
CYCLOMARK TABLET is unlikely to affect your ability to drive and/or operate machines. Consult your doctor before taking the medicine.
ALCOHOL
Avoid consumption of alcohol while taking CYCLOMARK TABLET as it may increase the risk of intoxication.
KIDNEY
CYCLOMARK TABLET should be used with caution in patients with kidney problems such as severe renal insufficiency. Contact your doctor before taking CYCLOMARK TABLET.
LIVER
CYCLOMARK TABLET is not recommended for use in patients with liver problems such as severe hepatic insufficiency. It should be used with caution in patients with mild to moderate hepatic insufficiency and other liver disorders. Consult your doctor before taking the medicine.
ALLERGY
Do not take CYCLOMARK TABLET if you are allergic to dicyclomine, paracetamol, and/or any other ingredients of this medicine.
OTHERS
CYCLOMARK TABLET is not recommended for use if you have:
A history of known idiosyncrasy (adverse effect) to dicyclomine
Before taking CYCLOMARK TABLET inform your doctor if you:
Have/suspected of having glaucoma (increased eye pressure)

Prostatic hypertrophy (prostate gland enlargement)

Have hiatus hernia associated with reflux oesophagitis (inflammation of oesophagus)

Suffer from low glutathione (antioxidant) reserves

Suffer from Glucose-6-phosphate-dehydrogenase deficiency

Have Gilbert?s syndrome (inherited liver disorder)
Use in Paediatrics:
CYCLOMARK TABLET is not recommended for use in children and adolescents (below 12 years of age). Consult your doctor before taking CYCLOMARK TABLET.
Use in Geriatrics:
CYCLOMARK TABLET is not recommended for use in elderly patients. Contact your doctor before taking CYCLOMARK TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking CYCLOMARK TABLET, inform your doctor if you are taking any of the following medicine:
Antiepileptics (use to treat epilepsy) Ex. phenobarbital, phenytoin, carbamazepine, topiramate

Rifampicin (used to treat tuberculosis)

Medicines used to prevent blood clots such antivitamin K (Ex. warfarin)

Flucloxacillin (used to treat skin, wound, bone infections)

Chelating resin (medicine used to treat mercury & lead toxicity, and blood transfusion dependent anaemias)

Metoclopramide, domperidone (used to stop nausea and vomiting)
Overdosage:
If you or anyone else accidentally take too much of CYCLOMARK TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are abdominal pain, pallor, headache, dizziness, nausea, dry mouth, difficulty in swallowing, anorexia, dilated pupils, dry skin, hepatic cytolysis (harmful immunoallergic reaction which leads to liver failure), gastrointestinal bleeding, metabolic acidosis (excess acid production in the body), encephalopathy (brain disease that alters brain function), disseminated intravascular coagulation (serious blood disorder that affects bleeding), pancreatitis (inflammation of pancreas), pancytopenia (deficiency of red blood/white blood/platelets), acute renal failure, and coma.
SYNOPSIS

Drug :?? Dicyclomine, Paracetamol

Pharmacological Category :?? Antispasmodics, Analgesics

Therapeutic Indication :?? Spasmodic pain and discomfort (due to biliary colic,intestinal colic, renal colic, spasmodic dysmenorrhea), Irritable bowel syndrome, Functional bowel disease? ? ? ?

Dosage Forms :?? Tablet, Suspension, Syrup

MORE INFORMATION

Keep CYCLOMARK TABLET out of reach of children

Do not store CYCLOMARK TABLET above 30?C

FAQs ABOUT CYCLOMARK TABLET
What is CYCLOMARK TABLET used for?
CYCLOMARK TABLET is used to provide relief from spasmodic pain and discomfort due to biliary colic (abdominal pain), intestinal colic (intestinal pain), renal colic (sharp pain due to kidney dysfunction), and spasmodic dysmenorrhea (sharp pelvic pain at the start of menstrual flow) in affected individuals. It is also used to provide relief from the symptoms of irritable bowel syndrome (IBS) and functional bowel disease in affected individuals.
How to take CYCLOMARK TABLET?
Take CYCLOMARK TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
What are the side effects of CYCLOMARK TABLET?
The most common side effects of taking CYCLOMARK TABLET are hypersensitivity reaction (immune mediated reaction), dry mouth, stomach upset, bloating, flatulence, vomiting, and/or constipation. Consult your doctor if any of these symptoms worsens.
How CYCLOMARK TABLET works?
CYCLOMARK TABLET provides relief from spasmodic pain and discomfort, where Dicyclomine relieves abdominal cramps, pain, bloating and discomfort by relaxing the muscles in the stomach & gut and preventing the occurrence of sudden muscle contractions and Paracetamol provides relief from pain by blocking the action of prostaglandin (chemical messengers responsible for pain) thus providing reducing spasmodic pain and discomfort in affected individuals.
Can CYCLOMARK TABLET be used in pregnant and breastfeeding women?
Yes, CYCLOMARK TABLET can be used but with caution in pregnant and breastfeeding women only if it is clearly necessary. Consult your doctor before taking the medicine.
REFERENCES
1. KD. Tripathi. Anticholinergic Drugs and Drugs Acting on Autonomic Ganglia. Essentials of medical pharmacology. Seventh edition. 2013. Page ? 117.
2. KD. Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of medical pharmacology. Seventh edition. 2013. Page ? 206.
3. Dicyclomine. NIH National Library of Medicine. National center for biotechnology information. PubChem. October 2022. [Accessed on 12th September 2022]?https://pubchem.ncbi.nlm.nih.gov/compound/Dicyclomine#section=Metabolism-Metabolites
4. Marta J?zwiak-Bebenista, Jerzy Z Nowak. Paracetamol: mechanism of action, applications and safety concern. ?NIH National Library of Medicine. National center for biotechnology information. PubMed.gov. 2014. [Accessed on 12th September 2022]?https://pubmed.ncbi.nlm.nih.gov/24779190/
5. Audrey Rankin, Cathal A Cadogan, Susan M Patterson, Ngaire Kerse, Chris R Cardwell, Marie C Bradley, Cristin Ryan, Carmel Hughes, Cochrane Effective Practice and Organisation of Care Group.? Interventions to improve the appropriate use of polypharmacy for older people. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. 2018. [Accessed on 12th September 2022]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513645
6.?Leeford Healthcare Limited. LEEMOL-DC TABLET. [Accessed on 12th September 2022]?https://www.leeford.in/product/1015/leemol-dc-tablet
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8. Mapro Lifescience. Cyclopex. [Accessed on 12th September 2022]?https://maprolifescience.com/product/cyclopex/
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10. Sanofi S.A. Baralgan NU. [Revised in August 2021] [Accessed on 12th September 2022]?https://www.sanofi.in/dam/jcr:79ac7a65-edc5-434b-84d2-bb22fa2d25fa/Baralgan%20NU%20PI%20_Aug%202021.pdf
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