TOPILIV 50 Tablet 10?s Allschoolabs -

Description

INTRODUCTION
TOPILIV 50 TABLET contains Topiramate, which belongs to the group of medicines called anticonvulsants. It is used in the treatment of seizure disorders in adults and children (over 6 years of age) alone, as well as in adults and children over 2 years of age. A seizure is a sudden, uncontrolled disturbance in the brain that can cause changes in your behaviour, movements, feelings, and consciousness level.
TOPILIV 50 TABLET is also used in the prevention of a type of one-sided headache called migraine headaches that causes severe throbbing pain or a pulsing sensation, nausea, vomiting, and extreme sensitivity to light and sound.
TOPILIV 50 TABLET should be taken with caution in patients with liver and kidney problems, a history of blood and body fluid abnormalities (metabolic acidosis), eye problems such as glaucoma (a condition that damages the optic nerve), growth problems, and patients who are on a high-fat diet (a ketogenic diet).
TOPILIV 50 TABLET is not recommended for use during pregnancy or breastfeeding or by women planning for pregnancy. TOPILIV 50 TABLET should be used with caution in children (2-16 years old) and the elderly.
The most common side effects of using TOPILIV 50 TABLET are stuffy, runny nose, or sore throat; tingling, pain, and/or numbness, sleepiness, tiredness, dizziness, nausea, diarrhoea, weight changes (weight loss or gain), and behavioural changes. Talk to your doctor if any of the symptoms get worse.
USES OF TOPILIV 50 TABLET

Treatment of seizures in adults and children (above 6 years of age) alone

Treat seizures in adults and children above 2 years of age along with other medicines

Prevention of migraine headaches in adults

HOW TOPILIV 50 TABLET WORKS
TOPILIV 50 TABLET blocks sodium channels in the body that deliver electrical impulses to excitable cells such as nerve, muscle, and brain cells. This in turn enhances the activity of a chemical messenger in the brain to control the frequency of seizures. TOPILIV 50 TABLET also prevents your nerve cells from sending inappropriate signals in the brain, which could lead to migraine headaches.
DIRECTIONS FOR USE
Take TOPILIV 50 TABLET as advised by your physician. Swallow the medicine completely and do not crush or chew the medicine as it may leave a bitter taste. Drink a lot of fluids while taking TOPILIV 50 TABLET. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF TOPILIV 50 TABLET

COMMON

Stuffy, runny nose or sore throat

Pain and change in sensations (tingling or numbness) of various body parts

Sleepiness, tiredness

Dizziness

Nausea, diarrhoea

Weight changes (weight loss or gain)

Signs of an allergic reaction (skin rash, redness, itching, facial swelling, hives)

Loss of appetite

Fever

Shortness of breath, cough, nose bleeds

Abnormal behaviour such as aggression, agitation, anger, and decreased ability to complete routine tasks, showing and/or feeling no emotion

Signs of decreased potassium level in the blood (muscles weakness and abnormal heart rhythms)

Watery eyes

Slow or irregular heartbeat

Difficulty falling or staying asleep

Problems with speech or speech disorder, slurred speech

Signs of lack of coordination such as feeling unsteady while walking

Decreased, loss of, or no sense of taste with dry mouth

Voluntary trembling or shaking; rapid, uncontrollable movements of the eyes

Signs of visual disturbances (double vision, blurred vision, decreased vision, difficulty focusing)

Vertigo (sensation of spinning), ringing in the ears, ear pain

Constipation, abdominal pain or discomfort, indigestion

Hair loss, itching

Joint pain and swelling with muscle spasms or twitching, muscle aches or weakness, chest pain

UNCOMMON

Signs of decreased count in platelets and white blood cells (easy bleeding from wounds that lasts for a prolonged period or doesn?t stop on its own along with repeated fevers and infections)

Signs of increased liver enzymes (stomach pain, dark urine, feeling tired, itching and yellowing of your skin or eyes)

Swelling of glands present in the neck, armpit, or groin

Increased appetite

Elevated mood

Signs of psychosis (hearing, seeing, or feeling things that are not there)

Showing and/or feeling no emotion, unusual suspiciousness, panic attack

Speech problems

Restlessness, hyperactivity

Slowed thinking, decreased wakefulness or alertness

Body movements reduced or become slow with involuntary abnormal or repetitive muscle movements

Fainting

Abnormal or impaired sense of touch and smell

Unusual feeling or sensation that may precede a migraine or a certain type of seizure

Dry, watery eyes with increased sensitivity to light, and eyelid twitching

Decreased or loss of hearing in one ear

Feeling your heart beating in your chest (either slow or irregular)

Low blood pressure upon standing

Feeling like fainting, dizzy, or may pass out when they stand up or sit up suddenly

Flushing, feeling warm

Signs of inflammation of the pancreas (upper stomach pain that radiates to your back along with fever, nausea and vomiting)

Heartburn with abdominal fullness or bloating

Bleeding gums, increased saliva, drooling, breath odour

Excessive thirst

Discolouration of the skin

Muscle stiffness and pain on one side

Blood in urine along with lack of control of urine, pain

Sexual dysfunction (difficulty getting or keeping an erection)

Signs of flu (fever, chills, muscle ache, cough, congestion, runny nose, headache and fatigue)

Fingers and toes feeling cold

Feeling like a drunk

Learning disability

RARE

Abnormally elevated mood

Loss of consciousness

Blindness in one eye (temporary or night blindness)

Signs of lazy eye (wandering eyes that may not appear to work together or poor depth perception

Swelling in and around the eyes

Change in colour and sensation of fingers and toes when exposed to the cold

Signs of liver inflammation and liver failure (yellowed skin and eyes along with stomach pain and swelling)

Abnormal skin odour

Discomfort in your arms or legs

Signs of kidney disorder (nausea, vomiting, loss of appetite, fatigue and weakness, sleep problems, decreased mental sharpness and muscle cramps)
Stop taking TOPILIV 50 TABLET and contact your doctor immediately if you experience any of the following side effects:
New or worsening signs of depression (persistent low mood, loss of interest in things, feelings of worthlessness and thoughts of harming yourself)

Seizures (fits)

Mood changes, anxiety, irritability, confusion, disorientation

Concentration problems, slow thinking, loss of memory

Signs of kidney stone (frequent or painful urination)

Signs of the increased acid level in the blood (troubled breathing including shortness of breath, loss of appetite, nausea, vomiting, excessive tiredness, and fast or uneven heartbeats)

Serious self-harming thoughts or trying to cause serious self-harm

Loss of part of the field of vision (difficulty finding or reaching for objects)

Signs of glaucoma blockage of fluid in the eye causing increased pressure in the eye, pain, or decreased vision

Signs of a high level of ammonia in the blood (changes in brain function leading to difficulty in thinking, remembering information, or solving problems, being less alert or aware, feeling very sleepy with low energy)

Signs of serious skin reactions, such as stevens-johnson syndrome and toxic epidermal necrolysis (rashes with or without blisters, skin irritation, sores or swelling in the mouth, throat, nose, eyes and around the genitals leading to peeling of the skin)

HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Take this medicine along with, or just after meals. Stick to simple meals and avoid eating oil-rich or spicy foods. If the symptom does not improve, contact your doctor.
Abdominal discomfort:
Avoid heavy meals and eat smaller meals at regular intervals. Drink a lot of fluids and go for short walks. If the symptom does not improve, contact your doctor.
Constipation:
Eat plenty of fiber-rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. If the symptom does not improve, contact your doctor.
Stomach pain:
Take rest and try to have smaller and more frequent meals. Drink a lot of water. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.
Dizziness:
Sit down or lie down slowly when you are feeling dizzy. Take rest for some time and drink plenty of water. Avoid coffee and other carbonated drinks. If the symptom does not improve, contact your doctor.
WARNING & PRECAUTIONS

PREGNANCY
TOPILIV 50 TABLET is not recommended for use in pregnant women or women planning for pregnancy as it may increase the risk of birth defects such as cleft lip (split in the top lip) and cleft palate (split in the roof of the mouth) and malformation of the penis (hypospadia). These defects can develop even early in pregnancy. Therefore, talk to your doctor about the best kind of contraception and consult whether TOPILIV 50 TABLET is suitable for you doctor before starting the medicine.
BREASTFEEDING
TOPILIV 50 TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk and cause diarrhoea, sleepiness, irritability, and poor weight gain in infants. Therefore, you should consult your doctor before taking this medicine whether to abstain from breastfeeding or treatment with TOPILIV 50 TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines after taking TOPILIV 50 TABLET, it might cause dizziness, tiredness, and vision problems. Consult your doctor before driving or using any tools or machines.
ALCOHOL
Avoid consumption of alcohol while taking TOPILIV 50 TABLET.
KIDNEY
TOPILIV 50 TABLET should be taken with caution in patients having kidney problems, especially kidney stones, or undergoing kidney dialysis. Consult your doctor before taking this medicine.
LIVER
TOPILIV 50 TABLET should be taken with caution in patients with liver problems. Consult your doctor before taking this medicine.
ALLERGY
Do not take TOPILIV 50 TABLET if you are allergic to topiramate.
OTHERS
Before taking TOPILIV 50 TABLET, inform your doctor if you:
Have a history of blood and body fluid abnormality (metabolic acidosis)

Have eye problems, especially glaucoma (a condition that damages the optic nerve)

Have problems with growth

Are on a high-fat diet (ketogenic diet)
Use in Pediatrics:
TOPILIV 50 TABLET should be used with caution in children (above 2 years up to 16 years of age). It is not recommended for migraine prevention in children. Consult your doctor before taking this medicine.
Use in Geriatrics:
TOPILIV 50 TABLET should be used with caution in elderly patients. Consult your doctor before taking this medicine.
INTERACTIONS
A. Drug-Drug interactions:
Before taking TOPILIV 50 TABLET, inform your doctor if you are taking any of the following medicine:
Medicines that impair or decrease your thinking, concentration, or muscle coordination [Ex. diazepam, clonazepam, alprazolam, triazolam, zolpidem]

Medicines that are used to prevent pregnancy [Ex. levonorgestrel, drospirenone / ethinyl estradiol, medroxyprogesterone]

Other medicines used in the treatment of epilepsy [Ex. risperidone, lithium, hydrochlorothiazide, metformin, pioglitazone, glibenclamide, amitriptyline,

Propranolol, diltiazem, venlafaxine, flunarizine]

St. John?s wort (hypericum perforatum) [herbal preparation used to treat depression)

Warfarin [medicine used to prevent the clotting of blood]
Overdosage:
If you or anyone else accidentally take too much of TOPILIV 50 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling sleepy, tired, or less alert, dizzy due to low blood pressure, feeling depressed or agitated, lack of coordination, difficulty in speaking or concentrating; blurred vision, abdominal pain, or seizures (fits).
SYNOPSIS

Drug :?? Topiramate

Pharmacological Category :?? Anticonvulsants

Therapeutic Indication :?? Treats Epilepsy, Prevents Migraine ? ? ? ? ? ?

Dosage Forms :?? Tablet

MORE INFORMATION

Keep TOPILIV 50 TABLET out of reach from children

Store at room temperature

FAQs ABOUT TOPILIV 50 TABLET
What should I avoid while taking TOPILIV 50 TABLET?
Avoid the use of a ketogenic diet rich in fat and alcohol while you are taking TOPILIV 50 TABLET. This medicine can also make you feel tired and dizzy, increase the risk of kidney stones, and cause changes in the level of acid present in your blood. Therefore, it is best to avoid the ketogenic diet and alcohol while taking TOPILIV 50 TABLET. These two can further increase the changes caused by TOPILIV 50 TABLET. If you still have any discomfort, consult your doctor for more information.
Can TOPILIV 50 TABLET cause weight loss?
Yes. You may lose weight while taking TOPILIV 50 TABLET, so your weight should be checked regularly when using this medicine. If you are losing too much weight or a child using this medicine is not gaining enough weight, you should consult your doctor immediately.
Why do I need to drink a lot of water while taking TOPILIV 50 TABLET?
You need to drink plenty of water while taking TOPILIV 50 TABLET because it can cause an increase in your body temperature and reduce sweating, especially during hot weather and exercise. This can increase your chance of getting dehydrated and can cause kidney stones, especially if you are not drinking enough water.
How long do I need to take TOPILIV 50 TABLET?
The dose and duration of TOPILIV 50 TABLET will depend on your doctor?s advice. It does not cure your seizures or migraines, but it prevents them from occurring. So, you must continue taking it for months or years, depending on the improvement in your symptoms and any side effects that may occur. Always consult your doctor before starting this medicine.
What should be monitored while taking TOPILIV 50 TABLET?
Your doctor will do a blood test to measure the level of acid and ammonia in your blood before and during the treatment with TOPILIV 50 TABLET. The changes in your weight and eating pattern should be noted while taking this medicine. Some people will lose weight and lose their appetite. If you notice any drastic changes, consult your doctor immediately.
REFERENCES
1. KD Tripathi. Antiepileptic Drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page ? 449.
2. Stephen D. Silberstein. ?Topiramate in migraine prevention: a 2016 perspective.? Headache: The Journal of Head and Face Pain. [Revised in November 2016] [Accessed on 20th May 2022]?https://doi.org/10.1111/head.12997
3. Bai, Yun-Fei, Chang Zeng, Miaomiao Jia, and Bo Xiao. ?Molecular mechanisms of topiramate and its clinical value in epilepsy.? Seizure Journal. [Revised in May 2022] [Accessed on 20th May 2022]?https://doi.org/10.1016/j.seizure.2022.03.024
4. Janssen-Cilag Ltd. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed 20th May 2022]?https://www.medicines.org.uk/emc/files/pil.1442.pdf
5. IMED Healthcare Ltd. Health Products Regulatory Authority (HPRA). [Revised in September 2021] [Accessed on 20th May 2022]?https://www.hpra.ie/img/uploaded/swedocuments/3dd2dd21-1f7f-4124-9788-4371aec1879a.pdf
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