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Lopez 10 mgLopez 10 mg is indicated for the acute and maintenance treatment of schizophrenia and related psychoses where positive symptoms (e.g. delusions, hallucinations, disordered thinking, hostility and suspiciousness) and/or negative symptoms (e.g. flattened affect, emotional and social withdrawal, poverty ... Read moreLopez 10 mg is indicated for the acute and maintenance treatment of schizophrenia and related psychoses where positive symptoms (e.g. delusions, hallucinations, disordered thinking, hostility and suspiciousness) and/or negative symptoms (e.g. flattened affect, emotional and social withdrawal, poverty of speech) are prominent. Lopez 10 mg is indicated for the treatment of acute manic or mixed episodes in bipolar disorder, with or without psychotic features and with or without a rapid cycling courseTheropeutic ClassAtypical neuroleptic drugsPharmacologyLopez 10 mg is an antipsychotic agent and has affinities for serotonin 5HT2A/2C, 5HT3, 5HT6; dopamine D1, D2, D3, D4, D5; cholinergic muscarinic receptors M1-M5; ?1 adrenergic; and histamine H1 receptors. The mechanism of action of Lopez 10 mg, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug?s efficacy in schizophrenia is mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism. Lopez 10 mg is well absorbed after oral administration, reaching peak plasma concentrations within 5 to 8 hours. The absorption is not affected by food. Lopez 10 mg is not mutagenic or clastogenic as well as not carcinogenic.Dosage & Administration of Lopez 10 mgThe recommended starting dose for Lopez 10 mg is 10 mg/day, administered as a single daily dose without regard to meals. Daily dosage may subsequently be adjusted on the basis of individual clinical status within the range of 5-20 mg daily. An increase to a dose greater than the routine therapeutic dose of 10 mg/day i.e. to a dose of 15 mg/day or greater, is recommended only after appropriate clinical reassessment.When more than one factor is present which might result in slower?metabolism (female gender, geriatric age, non-smoking status), consideration should be given to decreasing the starting dose. Dose escalation, when indicated, should be conservative in such patients.Dosage of Lopez 10 mgSchizophrenia, combination therapy for Mania, Bipolar Disorder: The initial dose is 5-10 mg once daily. Daily dosage may subsequently be adjusted on the basis of individual clinical status within the range of 5-20 mg daily. Dosage greater than 10 mg daily only after reassessment. Maximum dose is 20 mg daily.Monotherapy for Mania: Initially 15 mg once daily. Daily dosage may subsequently be adjusted on the basis of individual clinical status within the range of 5-20 mg daily. Dosage greater than 15 mg only after reassessment. Maximum dose is 20 mg daily.Administration of Lopez 10 mgLopez 10 mg can be given without regard to meals. Gradual tapering of the dose should be considered while discontinuing Lopez 10 mg.Interaction of Lopez 10 mgLopez 10 mg may antagonize the effects of levodopa and dopamine agonists. Drugs that induce CYP1A2 or glucoronyl transferase enzymes e.g, Omeprazole and Rifampicin, may increase Lopez 10 mg clearance. Inhibitors of CYP1A2 may potentially inhibit Lopez 10 mg elimination. Carbamazepine may increase the clearance of Lopez 10 mg. Concomitant administration of activated charcoal reduces the oral bioavailability of Lopez 10 mg by 50-60%. Caution should be taken when Lopez 10 mg is administered with centrally acting drugs and alcohol.ContraindicationsLopez 10 mg is contraindicated in those patients with a known hypersensitivity to any ingredient of the product as well as in patients with known risk for narrow-angle glaucoma.Side Effects of Lopez 10 mgVery common undesirable effects are somnolence and weight gain. Besides increased appetite, elevated glucose levels, elevated triglyceride levels, dizziness, akathisia, Parkinson's disease, dyskinesia, orthostatic hypotension, mild and transient anticholinergic effects including constipation and dry mouth, asthenia, edema and photosensitivity reaction etc. may be observed.Pregnancy & LactationLopez 10 mg should be used in pregnancy only if the potential benefits justify the potential risk to the foetus. So, patients should be advised to notify their physician if they become pregnant or intend to become pregnant during treatment with Lopez 10 mg. There is no report to show teratogenecity. Patients should not breast feed if they are taking Lopez 10 mg.Precautions & WarningsLopez 10 mg should be used cautiously in patients who have a history of seizures or have conditions associated with seizures.?Lopez 10 mg should be used cautiously in patients with low leukocyte and/or neutrophil counts for any reason, drug induced bone marrow depression/toxicity caused by radiation therapy or chemotherapy, hypereosinophilic conditions, impaired hepatic function, and patients using hepatotoxic medicines, centrally acting drug and medicines know to increase QT interval, especially in the elderly. Patients should be cautioned about operating hazardous machinery, including motor vehicles.Storage ConditionsKeep below 30?C temperature, away from light & moisture. Keep out of the reach of children.Use In Special PopulationsChildren: Lopez 10 mg has not been studied in subjects under 18 years of age.Elderly patients (age 65 and over): starting dose 5 mg/dayPatients with hepatic, renal impairment: starting dose 5 mg/dayDrug ClassesAtypical neuroleptic drugsMode Of ActionLopez 10 mg is an antipsychotic agent and has affinities for serotonin 5HT2A/2C, 5HT3, 5HT6; dopamine D1, D2, D3, D4, D5; cholinergic muscarinic receptors M1-M5; ?1 adrenergic; and histamine H1 receptors. The mechanism of action of Lopez 10 mg, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug?s efficacy in schizophrenia is mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism. Lopez 10 mg is well absorbed after oral administration, reaching peak plasma concentrations within 5 to 8 hours. The absorption is not affected by food. Lopez 10 mg is not mutagenic or clastogenic as well as not carcinogenic.PregnancyLopez 10 mg should be used in pregnancy only if the potential benefits justify the potential risk to the foetus. So, patients should be advised to notify their physician if they become pregnant or intend to become pregnant during treatment with Lopez 10 mg. There is no report to show teratogenecity. Patients should not breast feed if they are taking Lopez 10 mg.Pediatric UsesChildren: Lopez 10 mg has not been studied in subjects under 18 years of age.Elderly patients (age 65 and over): starting dose 5 mg/dayPatients with hepatic, renal impairment: starting dose 5 mg/day