Lodicard 5 mg+50 mgAmlodipine & Atenolol is indicated in:
Hypertension not controlled by monotherapy
Angina pectoris & hypertension co-existing diseases
Post MI patients
Refractory angina pectoris where nitrate therapy has failed
Theropeutic ClassCombined antihypertensive preparationsPharmacologyAmlodipine is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle; it has a greater effect on vascular muscle than on cardiac muscle. Amlodipine is a peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Amlodipine reduces tone, decreases coronary vasoreactivity and lowers cardiac demand by reducing afterload. Atenolol is a cardio selective beta blocker. The cardio selectivity is dose related. Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS. Atenolol also causes a reduction in myocardial oxygen demand by virtue of its negative inotropic and negative chronotropic effects.Dosage & Administration of Lodicard 5 mg+50 mgThe recommended dosage is one tablet daily of (Amlodipine 5 mg & Atenolol 50 mg) or (Amlodipine 5 mg & Atenolol 25 mg). Depending upon the therapeutic response, titration of the dosage is recommended. In elderly patients, it is advisable to initiate the therapy with ? tablet of fixed dose combination of Amlodipine & Atenolol (i.e. 2.5 mg of Amlodipine & 25 mg Atenolol).Interaction of Lodicard 5 mg+50 mgAmlodipine has been safely administered with thiazide diuretics, beta blockers, alpha blockers, angiotensin converting enzyme inhibitors, long-acting nitrates, sublingual glyceryl trinitrate, non-steroidal anti-inflammatory agents, antibiotics, and oral hypoglycemic agents. In vitro data from studies with human plasma indicate that amlodipine has no effect on protein binding of the drugs tested (Digoxin, Phenytoin, Warfarin, or Indomethacin). Atenolol reduces the clearance of Disopyramide by 20%. Additive negative inotropic effects on the heart may be produced. At doses of 1 gm and above, Ampicillin may reduce Atenolol levels. Beta-blockers may decrease tissue sensitivity to Insulin and inhibit Insulin secretion, e.g. in response to oral antidiabetics. Atenolol has less potential for these actions.ContraindicationsHypersensitivity to either component, sinus bradycardia, second and higher degrees of heart block, cardiogenic shock, hypotension, congestive heart failure, poor left ventricular function.Side Effects of Lodicard 5 mg+50 mgThe combination of Amlodipine and Atenolol is well tolerated. Overall side effects include fatigue, headache, edema, nausea, drowsiness, anxiety and depression.Pregnancy & LactationAtenolol crosses the placenta. So it is contraindicated in pregnancy. It should be avoided during lactation.Precautions & WarningsAtenolol may mask the symptoms of hyperthyroidism. It may also mask the symptoms of hypoglycaemia, as well as enhance the effects of hypoglycaemic agents in patients with diabetes mellitus.Storage ConditionsStore in a cool dry place protected from light. Keep out of reach of children.
Lodipin 5 mgLodipin 5 mg is a calcium channel blocker and may be used alone or in combination with other antihypertensive and antianginal agents for the treatment of Hypertension and Coronary Artery Disease (such as Chronic Stable Angina, Vasospastic Angina and Angiographically Documented Coronary Artery Disease in patients without heart failure or an ejection fraction 1.0% are headache, fatigue, nausea, abdominal pain and somnolence.Pregnancy & LactationPregnancy Category C. There are no adequate and well-controlled studies of Lodipin 5 mg in pregnant women. Lodipin 5 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Lodipin 5 mg is excreted in human milk. In the absence of this information, it is recommended that nursing be discontinued while Lodipin 5 mg is administered.Precautions & WarningsSymptomatic hypotension is possible, particularly in patients with severe aortic stenosis. However, because of the gradual onset of action, acute hypotension is unlikely. Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of Lodipin 5 mg, particularly in patients with severe obstructive coronary artery disease. Titrate slowly when administering calcium channel blockers to patients with severe hepatic impairment.Overdose Effects of Lodipin 5 mgIn humans, experience with intentional overdose is limited.Symptoms: Available data suggest that large overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to and including shock with fatal outcome have been reported.Management: Clinically significant hypotension due to Lodipin 5 mg overdosage calls for active cardiovascular support including frequent monitoring of cardiac and respiratory function, elevation of extremities, and attention to circulating fluid volume and urine output.?A vasoconstrictor may be helpful in restoring vascular tone and blood pressure, provided that there is no contraindication to its use. Intravenous calcium gluconate may be beneficial in reversing the effects of calcium channel blockade. Gastric lavage may be worthwhile in some cases. In healthy volunteers the use of charcoal up to 2 hours after administration of Lodipin 5 mg 10 mg has been shown to reduce the absorption rate of Lodipin 5 mg. Since Lodipin 5 mg is highly protein-bound, dialysis is not likely to be of benefit.Storage Conditionskeep in a dry place away from light and heat. Keep out of the reach of children.Use In Special PopulationsChildren with hypertension from 6 years to 17 years of age: 2.5 mg once daily as a starting dose, up-titrated to 5 mg once daily if blood pressure goal is not achieved after 4 weeks. Doses in excess of 5 mg daily have not been studied in pediatric patients.Children under 6 years old: ?The effect of Lodipin 5 mg on blood pressure in patients less than 6 years of age is not known.Elderly: Lodipin 5 mg used at similar doses in elderly or younger patients is equally well tolerated. Normal dosage regimens are recommended in the elderly, but increase of the dosage should take place with care.Renal impairment: Changes in Lodipin 5 mg plasma concentrations are not correlated with degree of renal impairment, therefore the normal dosage is recommended. Lodipin 5 mg is not dialysable.Hepatic impairment: Dosage recommendations have not been established in patients with mild to moderate hepatic impairment; therefore dose selection should be cautions and should start at the lower end of the dosing range. The pharmacokinetics of Lodipin 5 mg have not been studied in severe hepatic impairment. Lodipin 5 mg should be initiated at the lowest dose (2.5 mg once daily) and titrated slowly in patients with severe hepatic impairment.
DR. ALADDIN’S THE SEVEN KEYS ₦5,200.00
This Japan type cutting plier is designed for cutting copper, aluminum and soft steel wires. Opposing twin blades make clean, even cuts through wire in solid, stranded, or braided forms. Features: Cut copper, aluminum and soft steel wire, cable wire, flexible copper wires & plastic burr, electronic feet, trimming plastic products, cut a small metal wire, etc. Made of heavy-duty high-carbon steel material, durable for use. Twin blades are hardened for superior performance. Slim grips are comfortable and easy to handle. Suitable for use in electronic industry repair, jewelry processing, model making and fishing, etc. NOTE: It is prohibited to use the tool to cut steel wire and hard metal. Specifications: Model: L202C02 / L202C04 / L204C18 / L201C15 / L209C22 (Optional) Size: 4.5"(L202C02) / 5"(L202C04) / 5"(L204C18) / 5"(L201C15) / 6"(L209C22) Type: L202C02 Diagonal Cutting Plier 115mm 4.5" L202C04 Diagonal Cutting Plier 125mm 5" L204C18 Flat Nose Plier 125mm 5" L201C15 Long Nose Plier Sharp-nose Pliers 125mm 5" L209C22 Diagonal Cutting Plier 150mm 6" Material: 55# High-carbon Steel Product Weight: 4.5"(L202C02) 74g / 5"(L202C04) 67g / 5"(L204C18) 70g / 5"(L201C15) 77g / 6"(L209C22) 120g Package Size: 18 * 7.5 * 2cm / 7.1 * 3.0 * 0.8in 6": 20.8 * 7.5 * 2cm / 8.2 * 3.0 * 0.8in Package Weight: 4.5"(L202C02) 90g / 5"(L202C04) 85g / 5"(L204C18) 86g / 5"(L201C15) 94g / 6"(L209C22) 140g Package List: 1 * Cutting Plier
Lodicard 5 mg+50 mgAmlodipine & Atenolol is indicated in: Hypertension not controlled by monotherapy Angina pectoris & hypertension co-existing diseases Post MI patients Refractory angina pectoris where nitrate therapy has failed Theropeutic ClassCombined antihypertensive preparationsPharmacologyAmlodipine is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle; it has a greater effect on vascular muscle than on cardiac muscle. Amlodipine is a peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Amlodipine reduces tone, decreases coronary vasoreactivity and lowers cardiac demand by reducing afterload. Atenolol is a cardio selective beta blocker. The cardio selectivity is dose related. Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS. Atenolol also causes a reduction in myocardial oxygen demand by virtue of its negative inotropic and negative chronotropic effects.Dosage & Administration of Lodicard 5 mg+50 mgThe recommended dosage is one tablet daily of (Amlodipine 5 mg & Atenolol 50 mg) or (Amlodipine 5 mg & Atenolol 25 mg). Depending upon the therapeutic response, titration of the dosage is recommended. In elderly patients, it is advisable to initiate the therapy with ? tablet of fixed dose combination of Amlodipine & Atenolol (i.e. 2.5 mg of Amlodipine & 25 mg Atenolol).Interaction of Lodicard 5 mg+50 mgAmlodipine has been safely administered with thiazide diuretics, beta blockers, alpha blockers, angiotensin converting enzyme inhibitors, long-acting nitrates, sublingual glyceryl trinitrate, non-steroidal anti-inflammatory agents, antibiotics, and oral hypoglycemic agents. In vitro data from studies with human plasma indicate that amlodipine has no effect on protein binding of the drugs tested (Digoxin, Phenytoin, Warfarin, or Indomethacin). Atenolol reduces the clearance of Disopyramide by 20%. Additive negative inotropic effects on the heart may be produced. At doses of 1 gm and above, Ampicillin may reduce Atenolol levels. Beta-blockers may decrease tissue sensitivity to Insulin and inhibit Insulin secretion, e.g. in response to oral antidiabetics. Atenolol has less potential for these actions.ContraindicationsHypersensitivity to either component, sinus bradycardia, second and higher degrees of heart block, cardiogenic shock, hypotension, congestive heart failure, poor left ventricular function.Side Effects of Lodicard 5 mg+50 mgThe combination of Amlodipine and Atenolol is well tolerated. Overall side effects include fatigue, headache, edema, nausea, drowsiness, anxiety and depression.Pregnancy & LactationAtenolol crosses the placenta. So it is contraindicated in pregnancy. It should be avoided during lactation.Precautions & WarningsAtenolol may mask the symptoms of hyperthyroidism. It may also mask the symptoms of hypoglycaemia, as well as enhance the effects of hypoglycaemic agents in patients with diabetes mellitus.Storage ConditionsStore in a cool dry place protected from light. Keep out of reach of children.