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Lodopin Tablets SpecificationRequires Prescription (YES/NO)YesGenericsAmlodipine BesylateUsed ForHypertensionHow it worksThe mechanism of the antihypertensive action of amlodipine is due to direct relaxant effect on vascular smooth muscle. The precise mechanism by which amlodipine relieves angina has not been fully determined but amlodipine reduces total ischemic burden by the following two actions. Amlodipine dilates peripheral arterioles thus, reduces the total peripheral resistance (after load) against which the heart works.Lodopin Tablets Usage And SafetyDosageAmlodipine BesylateSide EffectsAmlodipine Besylate is well tolerated; the most commonly observed side effects were headache, edema, fatigue, nausea, flushing and dizziness.Drug InteractionsAzole antifungals , erythromycin , cyclosporins , sildenafil , rifampicin , dantrolene , simvastatin , tacrolimus , other antihypertensives , grape fruit juice.IndicationAmlodipine Besylate is indicated for the first line treatment of hypertension and can be used as the sole agent to control blood pressure in the majority of patients.Amlodipine Besylate is indicated for the first line treatment of myocardial ischemia whether due to fixed obstruction (stable angina) and/ or vasospasm/vasoconstriction (prinzmetal?s or variant angina) of coronary vasculature.When not to UseAmlodipine Besylate is contraindicated in patients with a known hypersensitivity to dihydropyridines.Lodopin Tablets PrecautionsPrecautionAmlodipine Besylate used at similar doses in elderly or younger patients, is equally well tolerated. Therefore, normal dosage regimens are recommended.Lodopin Tablets WarningsWarning 1Changes in Amlodipine Besylate plasma concentrations are not correlated with degree of renal impairment. Amlodipine Besylate may be used in such patients at normal doses.Warning 2Amlodipine Besylate half life is prolonged in patients with impaired liver function, the drug should therefore be administered with caution in these patients.Warning 3Safety of Amlodipine Besylate in human pregnancy or lactation has not been established.Lodopin Tablets Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.

Lodopin-V Tablets SpecificationRequires Prescription (YES/NO)YesGenericsAmlodipine Besilate + ValsartanUsed ForHypertensionHow it worksAmlodipine and Valsartan are antihypertensive compounds with complementary mechanisms to control blood pressure in patients with essential hypertension. The combination of these substances has an additive antihypertensive effect, reducing blood pressure to a greater degree than either component alone.Lodopin-V Tablets Usage And SafetyDosageAmlodipine Besilate + ValsartanSide EffectsNasopharyngitis, influenza, hypokalemia, headache, asthenia, fatigue, facial edema, flushing, hot flush, edema, edema peripheral and pitting edema , Anorexia, hypercalcemia, hyperlipidemia, hyperuricemia, hyponatremia, coordination abnormal, dizziness, dizziness postural, paraesthesia, somnolence, visual impairment, vertigo, palpitations, tachycardia, orthostatic hypotension, cough, pharyngolaryngeal pain, abdominal discomfort, abdominal pain upper, constipation, diarrhea, dry mouth, nausea, erythema, rash, arthralgia, back pain and joint swelling.Drug InteractionsAntihypertensive agents , grapefruit or grapefruit juice , CYP3A4 inhibitors (protease inhibitors, azole antifungals, macrolides like erythromycin or clarithromycin, verapamil or diltiazem) , CYP3A4 inducers (e.g. rifampicin, Hypericum perforatum) , Simvastatin , Lithium , Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium , NSAIDs , (rifampicin, cyclosporine) or efflux transporter (ritonavir) , Sildenafil.IndicationIt is indicated for the treatment of Hypertension.When not to UseThe combination of amlodipine and valsartan is contraindicated in: - Patients with known hypersensitivity to the active substances, to dihydropyridine derivatives or to any of the excipient of the product. Severe hepatic impairment, biliary cirrhosis or cholestasis.Lodopin-V Tablets PrecautionsPrecautionCombination of amlodipine + valsartan should be used with caution to treat hypertension in patients with unilateral or bilateral renal artery stenosis or stenosis to a solitary kidney since blood urea and serum creatinine may increase in such patients.Lodopin-V Tablets WarningsWarning 1Concomitant use with potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium, or other medicinal products that may increase potassium levels (heparin, etc.) should be undertaken with caution and with frequent monitoring of potassium levels.Warning 2The safety and efficacy of amlodipine in hypertensive crisis have not been established.Warning 3Angioedema, including swelling of the larynx and glottis, causing airway obstruction and/or swelling of the face, lips, pharynx and/or tongue, has been reported in patients treated with valsartan. Combination of amlodipine + valsartan should be discontinued immediately in patients who develop angioedema and should not be re-administered.Lodopin-V Tablets Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.

Lodopin-V Tablets SpecificationRequires Prescription (YES/NO)YesGenericsAmlodipine Besilate + ValsartanUsed ForHypertensionHow it worksAmlodipine and Valsartan are antihypertensive compounds with complementary mechanisms to control blood pressure in patients with essential hypertension. The combination of these substances has an additive antihypertensive effect, reducing blood pressure to a greater degree than either component alone.Lodopin-V Tablets Usage And SafetyDosageAmlodipine Besilate + ValsartanSide EffectsNasopharyngitis, influenza, hypokalemia, headache, asthenia, fatigue, facial edema, flushing, hot flush, edema, edema peripheral and pitting edema , Anorexia, hypercalcemia, hyperlipidemia, hyperuricemia, hyponatremia, coordination abnormal, dizziness, dizziness postural, paraesthesia, somnolence, visual impairment, vertigo, palpitations, tachycardia, orthostatic hypotension, cough, pharyngolaryngeal pain, abdominal discomfort, abdominal pain upper, constipation, diarrhea, dry mouth, nausea, erythema, rash, arthralgia, back pain and joint swelling.Drug InteractionsAntihypertensive agents , grapefruit or grapefruit juice , CYP3A4 inhibitors (protease inhibitors, azole antifungals, macrolides like erythromycin or clarithromycin, verapamil or diltiazem) , CYP3A4 inducers (e.g. rifampicin, Hypericum perforatum) , Simvastatin , Lithium , Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium , NSAIDs , (rifampicin, cyclosporine) or efflux transporter (ritonavir) , Sildenafil.IndicationIt is indicated for the treatment of Hypertension.When not to UseThe combination of amlodipine and valsartan is contraindicated in: - Patients with known hypersensitivity to the active substances, to dihydropyridine derivatives or to any of the excipient of the product. Severe hepatic impairment, biliary cirrhosis or cholestasis.Lodopin-V Tablets PrecautionsPrecautionCombination of amlodipine + valsartan should be used with caution to treat hypertension in patients with unilateral or bilateral renal artery stenosis or stenosis to a solitary kidney since blood urea and serum creatinine may increase in such patients.Lodopin-V Tablets WarningsWarning 1Concomitant use with potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium, or other medicinal products that may increase potassium levels (heparin, etc.) should be undertaken with caution and with frequent monitoring of potassium levels.Warning 2The safety and efficacy of amlodipine in hypertensive crisis have not been established.Warning 3Angioedema, including swelling of the larynx and glottis, causing airway obstruction and/or swelling of the face, lips, pharynx and/or tongue, has been reported in patients treated with valsartan. Combination of amlodipine + valsartan should be discontinued immediately in patients who develop angioedema and should not be re-administered.Lodopin-V Tablets Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.