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Matropin 2%Matropin 2% sterile Eye Drops is indicated for use as a mydriatic and cycloplegic agent.Theropeutic ClassMydriatic and Cycloplegic agentsPharmacologyHomatropine, a tertiary amine antimuscarinic, produces dilation and loss of accommodation by blocking the response of iris sphincter muscle and the accommodative ciliary muscle to cholinergic stimulation.Dosage & Administration of Matropin 2%Mydriasis and cycloplegia for refraction: Adult: Instill 1 or 2 drops of 2% solution, or 1 drop of 5% solution immediately before the procedure, repeat at 5-10 minute intervals if necessary. Child: Instill 1 drop of 2% soln immediately before the procedure, repeat at 10-min intervals if necessary. Uveitis: Adult: Instill 1-2 drops of 2% or 5% solution bid-tid up to every 3-4 hr as needed. Child: 3 mth- 2 yr: instill 1 drop of 0.5% soln once daily or on alternate days. >2 yr: instill 1 drop of 1% or 2% soln bid. Dosage of Matropin 2%Mydriasis and cycloplegia for refraction: Adult: Instill 1 or 2 drops of 2% solution, or 1 drop of 5% solution immediately before the procedure, repeat at 5-10 minute intervals if necessary. Child: Instill 1 drop of 2% soln immediately before the procedure, repeat at 10-min intervals if necessary. Uveitis: Adult: Instill 1-2 drops of 2% or 5% solution bid-tid up to every 3-4 hr as needed. Child: 3 mth- 2 yr: instill 1 drop of 0.5% soln once daily or on alternate days. >2 yr: instill 1 drop of 1% or 2% soln bid. Interaction of Matropin 2%Effects may be increased by drugs with antimuscarinic effect such as; some antihistamines; phenothiazines; antipsychotics; TCAs; MAOIs or parasympathomimetics.ContraindicationsContraindicated in patients with closed-angle glaucoma or with a narrow angle between the iris and the cornea.Side Effects of Matropin 2%Hypersensitivity may occur as conjunctivitis.Pregnancy & LactationUse in pregnancy: There are no adequate and well-controlled studies in pregnant women. Matropin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Use in lactation: It is not known whether Homatropine is excreted in human milk. Caution should be exercised when Matropin is administered to a nursing mother.Precautions & WarningsShould be used with caution in patients with prostatic enlargement and in patients suffering from paralytic ileus or pyloric stenosis.Overdose Effects of Matropin 2%Ataxia, incoherent speech, restlessness, hallucinations, disorientation, failure to recognize people and tachycardia. Psychotic reactions and behavioural disturbances (in children). SC/IM/IV Physostigmine salicylate 1-2 mg to control central and peripheral effects. Small doses of short-acting barbiturate eg. thiopentone sodium 100 mg to control excitement.Use In Special PopulationsUse in children: Should not be used in children below the age of 3 monthsDrug ClassesMydriatic and Cycloplegic agentsMode Of ActionHomatropine, a tertiary amine antimuscarinic, produces dilation and loss of accommodation by blocking the response of iris sphincter muscle and the accommodative ciliary muscle to cholinergic stimulation.PregnancyUse in pregnancy: There are no adequate and well-controlled studies in pregnant women. Matropin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Use in lactation: It is not known whether Homatropine is excreted in human milk. Caution should be exercised when Matropin is administered to a nursing mother.Pediatric UsesUse in children: Should not be used in children below the age of 3 months