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Merison 6 mgMerison 6 mg is indicated in vertigo and dizziness associated with the following diseases: Meniere's disease, Meniere's syndrome, Peripheral vertigo.Theropeutic ClassDrugs used in meniere's diseasesPharmacologyThe mechanism of action of betahistine is known partially. Betahistine has a very strong affinity as an antagonist for histamine H3 receptors and a weak affinity as an agonist for histamine H1 receptors. The active ingredient is a specific histamine agonist with virtually no H2-activity.Betahistine has two modes of action. Primarily, it has a direct stimulating (agonistic) effect on H1 receptors located on blood vessels in the inner ear. It appears to act on the precapillary sphincter in the stria vascularis of the inner ear, thus reducing the pressure in the endolymphatic space.In addition, betahistine has a powerful antagonistic effects at H3 receptors, and increases the levels of neurotransmitters released from the nerve endings. The increased amounts of histamine released from histaminergic nerve endings stimulates H1 receptors, thus augmenting the direct agonistic effects of betahistine on these receptors. This explains the potent vasodilatory effects of betahistine in the inner ear. This explains the efficacy of betahistine in the treatment of vertigo.Dosage & Administration of Merison 6 mgUsually for adults, administer orally 6 mg to 12 mg three times per day after meals. The dose may be adjusted according to the age of patient and severity of symptoms.Dosage of Merison 6 mgUsually, for adults, administer orally 1 to 2 tablets three times per day after meals. The dose may be adjusted according to the age of patient and severity of symptoms.ContraindicationsHypersensitivity to Merison 6 mg, pheochromocytoma, peptic ulcer, acute bronchial asthma.Side Effects of Merison 6 mgDigestive: Nausea or vomiting may rarely occur. Hypersensitivity: Hypersensitivity reactions, such as skin rash, may rarely occur.Pregnancy & LactationSafety of Betahistine during pregnancy has not been established. This drug should be administered to pregnant patients or women suspected of being pregnant, only if the expected therapeutic benefit is thought to outweigh any possible risk.Precautions & WarningsPatients with a history of digestive ulcer or an active digestive ulcer, Patients with bronchial asthma, Patients with pheochromocytoma.Storage ConditionsStore in cool and dry place. Protect from light & moisture.Drug ClassesDrugs used in meniere's diseasesMode Of ActionBetahistine Mesilate dilates precapillary sphincters, increasing the blood flow in the inner ear. It controls the permeability of capillaries in the inner ear, thereby removing endolymphatic hydrops. It also improves cerebral circulation, increasing blood flow in the internal carotid artery. Thus, Merison 6 mg is clinically useful for the relief of vertigo and dizziness.Betahistine Mesilate increases microcirculation blood flow in the inner ear, and removes endolymphatic hydrops of the inner ear. It also significantly increases the blood flow of the internal carotid artery. For discomfort accompanying cerebral disturbances: Betahistine exhibits a marked healing effect on giddiness experienced upon standing, the sensation of instability, and symptoms of dizziness. The heavy feeling in the head and the accompanying discomforts can also be successfully subdued. For dizziness and the sensation of dizziness due to disturbances in the inner ear: Betahistine improves microcirculation of the inner ear and removes endolymph hydrops, thereby alleviating dizziness in Meniere's disease and Meniere's syndrome. Tinnitus, the sensation of ear obstructions, nausea and vomiting are also effectively allayed. For the prevention of dizzy spells and other residual symptoms: Along with inhibiting the symptoms of dizziness and removing residual symptoms after the attack, continued administration of Merison 6 mg also prevents the recurrence of dizzy spells. As the primary in prescribing for dizziness: By the combined use with antihypertensive agents, therapeutic agents for arteriosclerosis, vitamins and tranquilizers, accompanying symptoms can also be brought into remission and better therapeutic effects obtained.PregnancySafety of Betahistine during pregnancy has not been established. This drug should be administered to pregnant patients or women suspected of being pregnant, only if the expected therapeutic benefit is thought to outweigh any possible risk.