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Melonin 3 mgMelonin 3 mg is used for numerous conditions but is showing the most promise in the short-term regulation of sleep patterns, including jet lag.Insomnia: Melonin 3 mg helps to induce sleep in people with- Disrupted circadian rhythms (such as those suffering from jet lag or poor vision or those who work the night shift) ... Read moreMelonin 3 mg is used for numerous conditions but is showing the most promise in the short-term regulation of sleep patterns, including jet lag.Insomnia: Melonin 3 mg helps to induce sleep in people with- Disrupted circadian rhythms (such as those suffering from jet lag or poor vision or those who work the night shift) Low Melonin 3 mg levels (such as some elderly and individuals with schizophrenia) Children with learning disabilities who suffer from insomnia. Osteoporosis: Melonin 3 mg stimulates cells called osteoblasts that promote bone growth.In Menopause: Melonin 3 mg helps peri- or postmenopausal women to regulate sleep patterns.Eating disorders: Melonin 3 mg levels may play a role in the symptoms of anorexia.Attention Deficit Hyperactivity Disorder (ADHD): it may be effective in managing sleep disturbances in children with this condition. AndSarcoidosisTheropeutic ClassHormone preparations for other uses, Oral nutritional preparationsPharmacologyMelonin 3 mg and Melonin 3 mg agonists inhibit the release of dopamine from retina through activation of a site that is pharmacologically different from a serotonin receptor. These inhibitory effects are antagonized by the Melonin 3 mg receptor antagonist luzindole, which suggests that Melonin 3 mg activates a presynaptic Melonin 3 mg receptor.Dosage & Administration of Melonin 3 mgAdult- Insomnia: 3-6 mg one hour before bedtimeJet lag: 0.50 to 5 mg one hour prior to bedtime at final destination or, 1 to 5 mg 1 hour before bedtime for 2 days prior to departure and for 2 to 3 days upon arrival at final destination. Eastbound travel: Take a preflight early evening treatment followed by treatment at bedtime for 4 days after arrival. Westbound travel: Take for 4 days at bedtime when in the new time zone. Sarcoidosis: 20 mg per day for 4 to 12 months.Depression: 0.125 mg twice in the late afternoon, each dose 4 hours apart.Difficulty falling asleep: 5 mg 3 to 4 hours before an imposed sleep period over a 4-weeks period. Children- 6 months to 14 years of age with sleep disorders: 0.30 mg/dayDosage of Melonin 3 mgAdult:Insomnia: 3-6 mg one hour before bedtimeJet lag: 0.50 to 5 mg one hour prior to bedtime at final destination or, 1 to 5 mg 1 hour before bedtime for 2 days prior to departure and for 2 to 3 days upon arrival at final destination. Eastbound travel- Take a preflight early evening treatment followed by treatment at bedtime for 4 days after arrival. Westbound travel- Take for 4 days at bedtime when in the new time zone. Sarcoidosis: 20 mg per day for 4 to 12 months.Depression: 0.125 mg twice in the late afternoon, each dose 4 hours apart.Difficulty falling asleep: 5 mg 3 to 4 hours before an imposed sleep period over a 4-weeks period.Children (6 months to 14 years of age): For sleep disorders?0.30 mg/dayInteraction of Melonin 3 mgAntidepressant Medications: Melonin 3 mg reduces the antidepressant effects of desipramine and fluoxetine. In addition, fluoxetine leads to measurable depletion of Melonin 3 mg in people.Antipsychotic Medications: People with schizophrenia and tardive dyskinesia taking antipsychotic medications with Melonin 3 mg has significantly reduced mouth movements compared to those who did not take the supplements.Benzodiazepines: The combination of Melonin 3 mg and triazolam improves sleep quality. In addition, there have been a few reports suggesting that Melonin 3 mg supplements may help individuals stop using long-term benzodiazepine therapy.Blood Pressure Medications: Melonin 3 mg may reduce the effectiveness of blood pressure medications like methoxamine and clonidine. In addition, calcium channel blockers (such as nifedipine, verapamil, diltiazem, amlodipine, nimodipine, felodipine, nisoldipine, and bepridil) may decrease Melonin 3 mg levels. The use of beta-blockers (propranolol, acebutolol, atenolol, labetalol, metoprolol, pindolol, nadolol, sotalol, and timolol) may reduce Melonin 3 mg production in the body.Blood-Thinning Medications, Anticoagulants: Melonin 3 mg may increase the risk of bleeding from anticoagulant medications such as warfarin.Interleukin-2: In one study of 80 cancer patients, the use of Melonin 3 mg in conjunction with interleukin-2 led to more tumor regression and better survival rates than treatment with interleukin-2 alone.Nonsteroidal Anti-inflammatory Drugs (NSAIDs): NSAIDs such as ibuprofen may reduce the levels of Melonin 3 mg in the blood.Steroids and Immunosuppressant Medications: People should not take Melonin 3 mg with corticosteroids or other medications used to suppress the immune system because the supplement may cause them to be ineffective.Tamoxifen: Preliminary research suggests that the combination of tamoxifen (a chemotherapy drug) and Melonin 3 mg may benefit certain patients with breast and other cancers.Other Substances: Caffeine, tobacco, and alcohol can all diminish levels of Melonin 3 mg in the body while cocaine and amphetamines may increase Melonin 3 mg production.ContraindicationsMelonin 3 mg should not be used by patients who have autoimmune diseases.Side Effects of Melonin 3 mgPossible adverse effects include headache and depression. Drowsiness may be experienced within 30 minutes after taking Melonin 3 mg and may persist for 1 hour and thus may affect driving skills.Pregnancy & LactationInformation regarding safety and efficacy in pregnancy and lactation is not available.Precautions & WarningsCaffeine and fluvoxamine may increase the effects of Melonin 3 mg, while Melonin 3 mg may decrease the antihypertensive effect of nifedipine.Overdose Effects of Melonin 3 mgThere is little or no evidence of any major toxicities with Melonin 3 mg,even at high doses.Storage ConditionsStore below 30?C. Keep away from light. Keep all the medicine out of reach of children.Drug ClassesHormone preparations for other uses, Oral nutritional preparationsMode Of ActionAfter administration, Melonin 3 mg binds with its receptors. Two types of Melonin 3 mg receptor subtypes - MT1 & MT2 have been identified in humans. Melonin 3 mg receptors are found in the brain and some peripheral organs. The MT1 subtype is present in the pars tuberalis of the pituitary gland and the suprachiasmatic nuclei of the hypothalamus. The MT2 subtype is mainly present in the retina. Increased level of Melonin 3 mg initiates neural & endocrine signals to optimize the levels of neurotransmitters e.g. increased serotonin, increased GABA & decreased dopamine, which induces & sustains sleep, as well as, maintains the body's circadian rhythm.PregnancyInformation regarding safety and efficacy in pregnancy and lactation is not available.