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MB 12 500 mcgMB 12 500 mcg is indicated in- Peripheral Neuropathies Diabetic Neuropathy Verteberal Syndrome Nerve Compression Syndrome Multiple sclerosis Amyotrophic lateral sclerosis Parkinson?s disease Alzheimer?s disease ... Read moreMB 12 500 mcg is indicated in- Peripheral Neuropathies Diabetic Neuropathy Verteberal Syndrome Nerve Compression Syndrome Multiple sclerosis Amyotrophic lateral sclerosis Parkinson?s disease Alzheimer?s disease Diabetic retinopathy Entrapment neuropathy Drug induced neuropathy Megaloblastic anemia due to Vitamin B12 deficiency Theropeutic ClassDrugs for Megaloblastic AnemiaPharmacologyMB 12 500 mcg is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.Dosage & Administration of MB 12 500 mcgTablet: The usual adult dosage is 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.?Injection: Peripheral neuropathies: The usual adult dosage is? 500 mcg MB 12 500 mcg administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.? Megaloblastic anemia: The usual adult dosage is? 500 mcg MB 12 500 mcg administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of MB 12 500 mcg every one to three months as maintenance therapy Dosage of MB 12 500 mcgTablet: The usual adult dosage is 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.?Injection: Peripheral neuropathies: The usual adult dosage is? 500 mcg MB 12 500 mcg administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.? Megaloblastic anemia: The usual adult dosage is? 500 mcg MB 12 500 mcg administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of MB 12 500 mcg every one to three months as maintenance therapy Interaction of MB 12 500 mcgDecreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.ContraindicationsHypersensitivity to any component of this product.Side Effects of MB 12 500 mcgGenerally MB 12 500 mcg is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of MB 12 500 mcg.Pregnancy & LactationNot recommended during pregnancy & lactation.Precautions & WarningsThe medicine should not be used for months if there is no response at all after its use for a certain period of time.Storage ConditionsOral: Store at room temperature. Protect from moisture and light.Parenteral: Store at room temperature. Do not expose to direct light.Use In Special PopulationsUse in children: Not recommended.Drug ClassesDrugs for Megaloblastic AnemiaMode Of ActionMB 12 500 mcg is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.PregnancyNot recommended during pregnancy & lactation.Pediatric UsesUse in children: Not recommended.