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One-3 Tablets SpecificationRequires Prescription (YES/NO)YesGenericsArtemether , Lumefantrine Used ForMalariaHow it worksBoth components Artemether/ Lumefantrine have their own action site in the malarial parasite. The presence of the endoperoxide bridge in Artemether (generating single oxygen and free radicals, those are very cytotoxic to the plasmodia) appears to be essential for antimalarial activity.One-3 Tablets Usage And SafetyDosageArtemether , Lumefantrine Side EffectsVery Common: Palpitations, headache, dizziness, abdominal pain, anorexia, vomiting, nausea, arthralgia, mylagia, asthenia, fatigue, sleep disorders.Common: Amnesia, paraesthesia, diarrhea, pruritus, rash, cough, electrocardiogram QT prolongation, gait disturbances, insomia.Uncommon: Liver function test increased, clonus, hypoesthesia, ataxia, somnolence.Drug InteractionsCYP3A4 inhibitors (e.g. erythromycin, ketoconazole, itraconazole, cimetidine, HIV protease inhibitors, etc.) , CYP2D6 inhibitors (e.g. flecainide, metoprolol, imipramine, amitryptyline, clomipramine, etc.) , Mefloquine.IndicationUsed in the treatment of Malaria.When not to UseIt is contraindicated to those patients which have a history of hypersensitivity to Artemether / Lumefantrine.One-3 Tablets PrecautionsPrecautionDue to limited data on safety and efficacy, Artemether+Lumefantrine should not be given concurrently with any other anti-malarial agent unless there is no other treatment option.One-3 Tablets WarningsWarning 1Caution is advised when administering Artemether + Lumefantrine to patients with severe renal, hepatic or cardiac problems. In such cases, monitoring of the ECG is recommended and steps should be taken to correct any electrolyte disturbances.Warning 2Caution is recommended when combining Artemether + Lumefantrine with drugs exhibiting variable patterns of inhibition, induction or competition for CYP3A4 as the therapeutic effects of some drugs could be altered.Warning 3Patients who remain averse to food during treatment should be closely monitored as the risk of recrudescence may be greater.One-3 Tablets Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.