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Flemo 40 mgUndenatured Collagen capsule is indicated for- Osteoarthritis Rheumatoid arthritis Joint pain & inflammation Difficulties in flexibility & mobility Joint discomfort & stiffness (knee extension) Impaired joint function Strenuous exercise & sports Theropeutic ClassHerbal and NutraceuticalsPharmacologyFlemo 40 mg derived from chicken sternum cartilage using a patented, low-temperature, non-enzymatic manufacturing process that preserves the natural triple helix molecular configuration and its biological activity. Undenatured collagen II has unique mechanism of action. Undenatured collagen II molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of undenatured collagen II interact with Peyer?s patches (lymphoid tissue) of small intestine to release collagen-specific regulatory T-cells. Collagen-specific regulatory T-cells then migrate to joint areas and prevent release of T-cells.Preventing the release of T-cells prevent the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of inflammatory cytokines resulting in reduction of inflammation, halting the erosion of joint cartilage and promote cartilage rebuilding.Flemo 40 mg supports joint function, mobility and flexibilityand? also improves knee extension by up to 10% for better range of motion. It also relieves joint pain due to strenuous exercise.Dosage & Administration of Flemo 40 mgOrally 1 capsule daily with water or as directed by the physician.Interaction of Flemo 40 mgNot known.ContraindicationsContraindicated in patients with known hypersensitivity to chicken or egg.Side Effects of Flemo 40 mgFlemo 40 mg is generally well tolerated in recommended dose. Over dose may cause constipation and headache.Pregnancy & LactationLack of scientific evidence on the use of undenatured collagen II during pregnancy or lactation.Storage ConditionsKeep away from direct sunlight and moisture, Store below 30?C temperature in cool and dry place. Keep the medicine out of reach of children.