Flontin 500 mgFlontin 500 mg is indicated for the treatment of single infection or mixed infections caused by two or more susceptible organisms. It can also be used for infections caused by organisms resistant to other antibiotics including Aminoglycosides, Penicillins and Cephalosporins.As antibacterial ... Read moreFlontin 500 mg is indicated for the treatment of single infection or mixed infections caused by two or more susceptible organisms. It can also be used for infections caused by organisms resistant to other antibiotics including Aminoglycosides, Penicillins and Cephalosporins.As antibacterial concentrations of Flontin 500 mg are obtained in serum and body tissues as well as in the urine following administration by mouth, Flontin 500 mg has been suggested for use in the treatment of a wide range of infections caused by susceptible organisms including infections of the urinary, respiratory and gastrointestinal tracts, gonorrhoea and septicaemia. The extensive tissue penetration of Flontin 500 mg combined with its enhanced antibacterial activity (including antipseudomonal activity), enables Flontin 500 mg to be used alone (pending sensitivity results) or in combination with an Aminoglycoside or with beta lactam antibiotics for instance when severe neutropenia is present or with an antibiotic active against anaerobes where the presence of bacteroides fragilis is suspected. Flontin 500 mg is indicated for the treatment of the following infections caused by sensitive bacteria:
Severe systemic infections: e.g. septicaemia, bacteraemia, peritionitis, infections in immunosuppressed patients with haematological or solid tumors and in patients in intensive care unit with specific problems such as infected burns.
Respiratory tract infections: Lobar and bronchopneumonia, acute and chronic bronchitis, acute exacerbation of cystic fibrosis, bronchiectasis, empyema.
Urinary tract infections: Uncomplicated and complicated urethritis, cystitis, pyelonephritis, prostatitis, epididymitis.
Skin and soft tissue infections: e.g. infected ulcers, wound infections, abscesses, cellulitis, otitis externa, erysipelas, infected burns.
Gastro-intestinal infections: e.g. enteric fever, infective diarrhea.
Infection of the biliary tract: e.g. cholangitis, cholecystitis, empyema of the gall bladder.
Intra abdominal infections: e.g. peritonitis, intra abdominal abscesses.
Bone and joint infection: Osteomyelitis, septic arthritis.
Pelvic infections: e.g. salpingitis, endometritis, pelvic inflammatory diseases.
Eye, ear, nose and throat infections: e.g. otitis media, sinusitis, mastoiditis, tonsillitis.
Gonorrhoea: Including urethral, rectal and pharyngeal gonorrhoea caused by beta-lactamase producing organisms or organisms moderately sensitive to penicillin.
Theropeutic Class4-Quinolone preparations, Anti-diarrhoeal Antimicrobial drugsPharmacologyFlontin 500 mg is a synthetic fluoroquinolone. It has bactericidal activity against a wide range of gram-positive and gram-negative organisms. It inhibits bacterial DNA synthesis by binding with the bacterial enzyme-DNA gyrase and topoisomerase IV which are responsible for DNA supercoiling.Dosage of Flontin 500 mgGeneral dosage recommendations: The dosage of the Flontin 500 mg is determined by the severity and type of infection, the sensitivity of the causative organism(s) and the age, weight and renal function of the patient.Adults: The dosage range for adults is 100-750 mg twice daily. In infections of the lower and upper urinary tract (depending on severity): 250-500 mg twice daily.In respiratory tract infections: 250-500mg twice daily for both upper and lower respiratory tract infections, depending on the severity. For the treatment of known Streptococcus pneumonia infection, the recommended dosage is 750 mg twice daily.In gonorrhea: A single dose of 250 or 500 mg.In the majority other infections: 500-750 mg twice daily should be administered.Cystic fibrosis: In adults with pseudomonal infections of the lower respiratory tract , the normal dose is 750 mg twice daily. As the pharmacokinetics of Flontin 500 mg remain unchanged in patients with cystic fibrosis, the low body weight of these patients would be fallen into consideration when determining dosage.Impaired renal function: Dosage adjustment is not usually required except in patients with several renal impairment. (serum creatinine >265 micro mol/l or creatinine clearance <20 ml/minute). If adjustment is necessary, this may be achieved by reducing the total daily dose by half, although monitoring of drug serum levels provide the most reliable basis for dose adjustment.Elderly: Although higher Flontin 500 mg serum levels are found in the elderly, no adjustment of dosage is necessary.Adeloscents and children: As with other drugs in its class, Flontin 500 mg has been shown to cause arthropathy in weight bearing joints of immature animals. Although the relevance of this to man is unknown, its use in children, growing children and growing adolescents is not recommended. However, where the benefit of using Flontin 500 mg is considered to outweigh the potential risk, the dosage should be 7.5-15 mg/kg/day depending upon the severity of infection, administered in two divided doses.Duration of treatment: The duration of treatment depends upon the severity of infection, clinical response and bacteriological findings.For acute infections: The usual treatment period is 5 to 10 days with Flontin 500 mg tablets. Generally treatment should be continued for three days after the signs and symptoms of the infection have disappeared.Extended-release tablet:
In uncomplicated urinary tract infection (acute cystitis), the recommended dose of extended-release tablet is 1000 mg tablet once daily for three days.
For IV infusion:
Urinary Tract Infection: Mild to Moderate: 200 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 12 hourly for 7-14 days
Lower Respiratory Tract infection: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days
Nosocomial Pneumonia: Mild/Moderate/Severe: 400 mg 8 hourly for 10-14 days
Skin and Skin Structure: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days
Bone and Joint Infection: Mild to Moderate: 400 mg 12 hourly for more than 4-6 weeks; Severe/Complicated: 400 mg 8 hourly for more than 4-6weeks
Intraabdominal (Acute abdomen): Complicated: 400 mg 12 hourly for 7-14 days
Acute Sinusitis: Mild/Moderate: 400 mg 12 hourly for 10 days
Chronic Bacterial Prostatitis: Mild/Moderate: 400 mg 12 hourly for 28 Days.
Administration of Flontin 500 mgInstruction for the use of Flontin 500 mg IV infusion-
Check the bag for minute leaks by squeezing the inner bag firmly. If leaks are found, or if seal is not intact, discard the solution.
Do not use if the solution is cloudy or a precipitate is present.
Do not use flexible bags in series connections.
Close flow control clamp of administration set.
Remove cover from port at bottom of bag.
Insert piercing pin of administration set into port with a twisting motion until the pin is firmly seated.
Suspend bag from hanger.
Squeeze and release drip chamber to establish proper fluid level in chamber during infusion of Flontin 500 mg IV infusion.
Open flow control clamp to expel air from set.Close clamp.
Regulate rate of administration with flow control clamp.
Interaction of Flontin 500 mgConcurrent administration of Flontin 500 mg should be avoided with Magnesium or Aluminum containing antacids or sucralfate or with other products containing Calcium, Iron or Zinc. These products may be taken two hours after or six hours before Flontin 500 mg. Flontin 500 mg should not be taken concurrently with milk or other dairy products, since absorption of Flontin 500 mg may be significantly reduced. Dietary calcium is a part of a meal, however, does not significantly affect the absorption of Flontin 500 mg.ContraindicationsPatients with a history of hypersensitivity to Flontin 500 mg or to other quinolones.Side Effects of Flontin 500 mgGastrointestinal disturbances e.g. nausea, diarrhoea, vomiting, dyspepsia, abdominal pain. Disturbances of the central nervous system e.g. headache, dizziness, tiredness, confusion, convulsion & risk of retinal detachment. Hypersensitivity reactions e.g. skin rash (very rarely Stevens-Johnson syndrome and toxic epidermal necrolysis), pruritus and possible systemic reactions. The other less reported reactions are joint pain, mild photosensitivity and transient increase in liver enzymes (particularly in patients with previous liver damage), serum bilirubin, urea or creatinine levels. Risk of hypoglycemia & mental health adverse effects.Pregnancy & LactationThere are no adequate and well-controlled studies in pregnant women. Flontin 500 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus and mother. Flontin 500 mg is excreted in human milk. Due to the potential risk of articular damage, Flontin 500 mg should not be used during lactation.Precautions & WarningsIt should be used with caution in patients with suspected or known CNS disorders such as arteriosclerosis or epilepsy or other factors which predispose to seizures and convulsion.
Flontin 500 mg may be taken with or without meals and to drink fluids liberally.
Concurrent administration of Flontin 500 mg should be avoided with magnesium / aluminium antacids, or sucralfate or with other products containing calcium, iron and zinc. These products may be taken two hours after or six hours before Flontin 500 mg.
Flontin 500 mg should not be taken concurrently with milk or yogurt alone, since absorption of Flontin 500 mg may be significantly reduced. Dietary calcium is a part of a meal, however, does not significantly affect the Flontin 500 mg absorption.
Overdose Effects of Flontin 500 mgOverdose following Flontin 500 mg administration may lead to seizures, hallucinations, confusion, abdominal discomfort, renal and hepatic impairment as well as crystalluria, haematuria, & reversible renal toxicity.Storage ConditionsKeep below 30?C temperature, protected from light & moisture. Keep out of the reach of children.Use In Special PopulationsAlthough effective in clinical trials, Flontin 500 mg is not a drug of first choice in pediatric population.Drug Classes4-Quinolone preparations, Anti-diarrhoeal Antimicrobial drugsMode Of ActionFlontin 500 mg is a synthetic quinolone anti-infective agent. Ciprofloxacion has broad spectrum of activity. It is active against most gram negative aerobic bacteria including Enterobacteriaceae and Pseudomonas aeruginosa. Flontin 500 mg is also active against gram-positive aerobic bacteria including penicillinase producing, non penicillinase producing, and methicillin resistant staphylococci, although many strains of streptococci are relatively resistant to the drug. The bactericidal action of Flontin 500 mg results from interference with the enzyme DNA gyrase needed for the synthesis of bacterial DNA. Following oral administration it is rapidly and well absorbed from the G.I. tract. It is widely distributed into the body tissues and fluids. The half life is about 3.5 hours. About 30% to 50% of an oral dose of Flontin 500 mg is excreted in the urine within 24 hours as unchanged drug and biologically active metabolites.PregnancyReproduction studies performed in mice, rats and rabbits using parenteral and oral administration did not reveal any evidence of teratogenicity, impairment of fertility or impairment of peri/post natal development. However as with other quinolones, Flontin 500 mg has been shown to cause arthropathy in immature animals and therefore its use during pregnancy is not recommended. Studies in rats have indicated that Flontin 500 mg is secreted in milk, administration to nursing mothers is thus not recommended.Pediatric UsesAlthough effective in clinical trials, Flontin 500 mg is not a drug of first choice in pediatric population.
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Flontin 500 mgFlontin 500 mg is indicated for the treatment of single infection or mixed infections caused by two or more susceptible organisms. It can also be used for infections caused by organisms resistant to other antibiotics including Aminoglycosides, Penicillins and Cephalosporins.As antibacterial ... Read moreFlontin 500 mg is indicated for the treatment of single infection or mixed infections caused by two or more susceptible organisms. It can also be used for infections caused by organisms resistant to other antibiotics including Aminoglycosides, Penicillins and Cephalosporins.As antibacterial concentrations of Flontin 500 mg are obtained in serum and body tissues as well as in the urine following administration by mouth, Flontin 500 mg has been suggested for use in the treatment of a wide range of infections caused by susceptible organisms including infections of the urinary, respiratory and gastrointestinal tracts, gonorrhoea and septicaemia. The extensive tissue penetration of Flontin 500 mg combined with its enhanced antibacterial activity (including antipseudomonal activity), enables Flontin 500 mg to be used alone (pending sensitivity results) or in combination with an Aminoglycoside or with beta lactam antibiotics for instance when severe neutropenia is present or with an antibiotic active against anaerobes where the presence of bacteroides fragilis is suspected. Flontin 500 mg is indicated for the treatment of the following infections caused by sensitive bacteria: Severe systemic infections: e.g. septicaemia, bacteraemia, peritionitis, infections in immunosuppressed patients with haematological or solid tumors and in patients in intensive care unit with specific problems such as infected burns. Respiratory tract infections: Lobar and bronchopneumonia, acute and chronic bronchitis, acute exacerbation of cystic fibrosis, bronchiectasis, empyema. Urinary tract infections: Uncomplicated and complicated urethritis, cystitis, pyelonephritis, prostatitis, epididymitis. Skin and soft tissue infections: e.g. infected ulcers, wound infections, abscesses, cellulitis, otitis externa, erysipelas, infected burns. Gastro-intestinal infections: e.g. enteric fever, infective diarrhea. Infection of the biliary tract: e.g. cholangitis, cholecystitis, empyema of the gall bladder. Intra abdominal infections: e.g. peritonitis, intra abdominal abscesses. Bone and joint infection: Osteomyelitis, septic arthritis. Pelvic infections: e.g. salpingitis, endometritis, pelvic inflammatory diseases. Eye, ear, nose and throat infections: e.g. otitis media, sinusitis, mastoiditis, tonsillitis. Gonorrhoea: Including urethral, rectal and pharyngeal gonorrhoea caused by beta-lactamase producing organisms or organisms moderately sensitive to penicillin. Theropeutic Class4-Quinolone preparations, Anti-diarrhoeal Antimicrobial drugsPharmacologyFlontin 500 mg is a synthetic fluoroquinolone. It has bactericidal activity against a wide range of gram-positive and gram-negative organisms. It inhibits bacterial DNA synthesis by binding with the bacterial enzyme-DNA gyrase and topoisomerase IV which are responsible for DNA supercoiling.Dosage of Flontin 500 mgGeneral dosage recommendations: The dosage of the Flontin 500 mg is determined by the severity and type of infection, the sensitivity of the causative organism(s) and the age, weight and renal function of the patient.Adults: The dosage range for adults is 100-750 mg twice daily. In infections of the lower and upper urinary tract (depending on severity): 250-500 mg twice daily.In respiratory tract infections: 250-500mg twice daily for both upper and lower respiratory tract infections, depending on the severity. For the treatment of known Streptococcus pneumonia infection, the recommended dosage is 750 mg twice daily.In gonorrhea: A single dose of 250 or 500 mg.In the majority other infections: 500-750 mg twice daily should be administered.Cystic fibrosis: In adults with pseudomonal infections of the lower respiratory tract , the normal dose is 750 mg twice daily. As the pharmacokinetics of Flontin 500 mg remain unchanged in patients with cystic fibrosis, the low body weight of these patients would be fallen into consideration when determining dosage.Impaired renal function: Dosage adjustment is not usually required except in patients with several renal impairment. (serum creatinine >265 micro mol/l or creatinine clearance <20 ml/minute). If adjustment is necessary, this may be achieved by reducing the total daily dose by half, although monitoring of drug serum levels provide the most reliable basis for dose adjustment.Elderly: Although higher Flontin 500 mg serum levels are found in the elderly, no adjustment of dosage is necessary.Adeloscents and children: As with other drugs in its class, Flontin 500 mg has been shown to cause arthropathy in weight bearing joints of immature animals. Although the relevance of this to man is unknown, its use in children, growing children and growing adolescents is not recommended. However, where the benefit of using Flontin 500 mg is considered to outweigh the potential risk, the dosage should be 7.5-15 mg/kg/day depending upon the severity of infection, administered in two divided doses.Duration of treatment: The duration of treatment depends upon the severity of infection, clinical response and bacteriological findings.For acute infections: The usual treatment period is 5 to 10 days with Flontin 500 mg tablets. Generally treatment should be continued for three days after the signs and symptoms of the infection have disappeared.Extended-release tablet: In uncomplicated urinary tract infection (acute cystitis), the recommended dose of extended-release tablet is 1000 mg tablet once daily for three days. For IV infusion: Urinary Tract Infection: Mild to Moderate: 200 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 12 hourly for 7-14 days Lower Respiratory Tract infection: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days Nosocomial Pneumonia: Mild/Moderate/Severe: 400 mg 8 hourly for 10-14 days Skin and Skin Structure: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days Bone and Joint Infection: Mild to Moderate: 400 mg 12 hourly for more than 4-6 weeks; Severe/Complicated: 400 mg 8 hourly for more than 4-6weeks Intraabdominal (Acute abdomen): Complicated: 400 mg 12 hourly for 7-14 days Acute Sinusitis: Mild/Moderate: 400 mg 12 hourly for 10 days Chronic Bacterial Prostatitis: Mild/Moderate: 400 mg 12 hourly for 28 Days. Administration of Flontin 500 mgInstruction for the use of Flontin 500 mg IV infusion- Check the bag for minute leaks by squeezing the inner bag firmly. If leaks are found, or if seal is not intact, discard the solution. Do not use if the solution is cloudy or a precipitate is present. Do not use flexible bags in series connections. Close flow control clamp of administration set. Remove cover from port at bottom of bag. Insert piercing pin of administration set into port with a twisting motion until the pin is firmly seated. Suspend bag from hanger. Squeeze and release drip chamber to establish proper fluid level in chamber during infusion of Flontin 500 mg IV infusion. Open flow control clamp to expel air from set.Close clamp. Regulate rate of administration with flow control clamp. Interaction of Flontin 500 mgConcurrent administration of Flontin 500 mg should be avoided with Magnesium or Aluminum containing antacids or sucralfate or with other products containing Calcium, Iron or Zinc. These products may be taken two hours after or six hours before Flontin 500 mg. Flontin 500 mg should not be taken concurrently with milk or other dairy products, since absorption of Flontin 500 mg may be significantly reduced. Dietary calcium is a part of a meal, however, does not significantly affect the absorption of Flontin 500 mg.ContraindicationsPatients with a history of hypersensitivity to Flontin 500 mg or to other quinolones.Side Effects of Flontin 500 mgGastrointestinal disturbances e.g. nausea, diarrhoea, vomiting, dyspepsia, abdominal pain. Disturbances of the central nervous system e.g. headache, dizziness, tiredness, confusion, convulsion & risk of retinal detachment. Hypersensitivity reactions e.g. skin rash (very rarely Stevens-Johnson syndrome and toxic epidermal necrolysis), pruritus and possible systemic reactions. The other less reported reactions are joint pain, mild photosensitivity and transient increase in liver enzymes (particularly in patients with previous liver damage), serum bilirubin, urea or creatinine levels. Risk of hypoglycemia & mental health adverse effects.Pregnancy & LactationThere are no adequate and well-controlled studies in pregnant women. Flontin 500 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus and mother. Flontin 500 mg is excreted in human milk. Due to the potential risk of articular damage, Flontin 500 mg should not be used during lactation.Precautions & WarningsIt should be used with caution in patients with suspected or known CNS disorders such as arteriosclerosis or epilepsy or other factors which predispose to seizures and convulsion. Flontin 500 mg may be taken with or without meals and to drink fluids liberally. Concurrent administration of Flontin 500 mg should be avoided with magnesium / aluminium antacids, or sucralfate or with other products containing calcium, iron and zinc. These products may be taken two hours after or six hours before Flontin 500 mg. Flontin 500 mg should not be taken concurrently with milk or yogurt alone, since absorption of Flontin 500 mg may be significantly reduced. Dietary calcium is a part of a meal, however, does not significantly affect the Flontin 500 mg absorption. Overdose Effects of Flontin 500 mgOverdose following Flontin 500 mg administration may lead to seizures, hallucinations, confusion, abdominal discomfort, renal and hepatic impairment as well as crystalluria, haematuria, & reversible renal toxicity.Storage ConditionsKeep below 30?C temperature, protected from light & moisture. Keep out of the reach of children.Use In Special PopulationsAlthough effective in clinical trials, Flontin 500 mg is not a drug of first choice in pediatric population.Drug Classes4-Quinolone preparations, Anti-diarrhoeal Antimicrobial drugsMode Of ActionFlontin 500 mg is a synthetic quinolone anti-infective agent. Ciprofloxacion has broad spectrum of activity. It is active against most gram negative aerobic bacteria including Enterobacteriaceae and Pseudomonas aeruginosa. Flontin 500 mg is also active against gram-positive aerobic bacteria including penicillinase producing, non penicillinase producing, and methicillin resistant staphylococci, although many strains of streptococci are relatively resistant to the drug. The bactericidal action of Flontin 500 mg results from interference with the enzyme DNA gyrase needed for the synthesis of bacterial DNA. Following oral administration it is rapidly and well absorbed from the G.I. tract. It is widely distributed into the body tissues and fluids. The half life is about 3.5 hours. About 30% to 50% of an oral dose of Flontin 500 mg is excreted in the urine within 24 hours as unchanged drug and biologically active metabolites.PregnancyReproduction studies performed in mice, rats and rabbits using parenteral and oral administration did not reveal any evidence of teratogenicity, impairment of fertility or impairment of peri/post natal development. However as with other quinolones, Flontin 500 mg has been shown to cause arthropathy in immature animals and therefore its use during pregnancy is not recommended. Studies in rats have indicated that Flontin 500 mg is secreted in milk, administration to nursing mothers is thus not recommended.Pediatric UsesAlthough effective in clinical trials, Flontin 500 mg is not a drug of first choice in pediatric population.
