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HPR-DS 500 mgMefenamic Acid is indicated for- Fever Toothache Headache Migraine Primary dysmenorrhoea Menorrhagia Mild to moderate pain in rheumatoid arthritis and osteoarthritis Traumatic pain Low-back pain Juvenile chronic arthritis in children etc. Theropeutic ClassDrugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)PharmacologyHPR-DS 500 mg, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties with minor anti-inflammatory activity.Dosage & Administration of HPR-DS 500 mgAs with other NSAIDs, the lowest dose should be sought for each patient. Therefore, after observing the response to initial therapy with HPR-DS 500 mg, the dose and frequency should be adjusted to suit an individual patient's needs.?Administration is by the oral route, preferably with food.Adult: A 500 mg dose should be given to adults up to three times (1.5 g total) per day.Infants over 6 months: 25 mg/kg of body weight daily in divided doses for not longer than 7 days.Dosage of HPR-DS 500 mgAdult: 500 mg dose should be given to adults upto three times (1.5 gm total) per day with meals. The dosage may be reduced to 1 tablet (250 mg) three times daily. In case of menorrhagia: 500 mg three times daily with meals and from the onset of menses and continued according to the judgement of the physician. Children: 6 months to 1 year: 5 ml three times/day. 2-4 years: 10 ml three times/day. 5-8 years: 10 ml four times /day. 9-12 years: 15 ml four times/day. Treatment should not be continued for more than 7 days except on the advice of a physician.Interaction of HPR-DS 500 mgAspirin: As other NSAIDs, concomitant administration of Mefenamic Acid and Aspirin is not generally recommended because of the potential of increased adverse effects.Warfarin: Mefenamic Acid can inhibit platelet aggregation and may prolong the prothrombin time in patients on warfarin therapyContraindicationsIt is contraindicated in patients with known hypersensitivity to Mefenamic Acid. It should not be used in patients with peptic ulcer, inflammatory bowel diseases, hepatic or renal impairment. It is also contraindicated in patients, whom aspirin and/or other NSAID's have induced symptoms of bronchospasm, skin rashes etc.Side Effects of HPR-DS 500 mgThe most frequently reported adverse experiences occurring in approximately 1-10% of patients are gastrointestinal: abdominal pain, constipation, diarrhoea, dyspepsia, flatulence, nausea, Gl ulcers, vomiting, dizziness, abnormal renal function, pruritus, rashes.Pregnancy & LactationPregnancy: In late pregnancy, as with other NSAIDs, HPR-DS 500 mg should be avoided because it may cause premature closure of the ductus arteriosus. In general there are no adequate and well controlled studies in pregnant women. HPR-DS 500 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Rated as Pregnancy Category C.Lactation: Trace amounts of HPR-DS 500 mg may be present in breast milk. Taking into account the importance of the drug to the mother , decision should be made whether to discontinue nursing or to discontinue the drug.Precautions & WarningsIt should be administered with caution in allergic diseases especially in asthma. The treatment should be withdrawn in diarrhoea, rashes, cholestatic jaundice, thrombocytopenia, haemolytic anaemia.Overdose Effects of HPR-DS 500 mgSymptoms: Headache, nausea, vomiting, epigastric pain, GI bleeding. Rarely, diarrhoea, disorientation, excitation, coma, drowsiness, tinnitus, fainting, and occasionally convulsions. Management: Symptomatic and supportive treatment. In acute overdosage, empty the stomach immediately by inducing emesis or by gastric lavage followed by admin of activated charcoal.Storage ConditionsKeep away from light, store in a cool and dry place. Keep out of reach of children.Drug ClassesDrugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)Mode Of ActionHPR-DS 500 mg contains Mefenamic Acid which is a nonsteroidal agent with demonstrated analgesic, anti-inflammatory and antipyretic activity due to its dual action on prostaglandins. It inhibits the enzymes of prostaglandin synthetase and also antagonizes the actions of prostaglandin at the receptor sites.PregnancyThe safety of HPR-DS 500 mg on reproductive capacity and pregnancy has not been established. Thus, HPR-DS 500 mg should be used in women of childbearing potential and during pregnancy only when the potential benefits are expected to outweigh the potential risks. Trace amounts of HPR-DS 500 mg may be present in breast milk and transmitted to the nursing infant. Thus HPR-DS 500 mg should not be taken by the nursing mother because of the effects of this class of drugs on the infant's cardiovascular system.

HPR 250 mgMefenamic Acid is indicated for- Fever Toothache Headache Migraine Primary dysmenorrhoea Menorrhagia Mild to moderate pain in rheumatoid arthritis and osteoarthritis Traumatic pain Low-back pain Juvenile chronic arthritis in children etc. Theropeutic ClassDrugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)PharmacologyHPR 250 mg, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties with minor anti-inflammatory activity.Dosage & Administration of HPR 250 mgAs with other NSAIDs, the lowest dose should be sought for each patient. Therefore, after observing the response to initial therapy with HPR 250 mg, the dose and frequency should be adjusted to suit an individual patient's needs.?Administration is by the oral route, preferably with food.Adult: A 500 mg dose should be given to adults up to three times (1.5 g total) per day.Infants over 6 months: 25 mg/kg of body weight daily in divided doses for not longer than 7 days.Dosage of HPR 250 mgAdult: 500 mg dose should be given to adults upto three times (1.5 gm total) per day with meals. The dosage may be reduced to 1 tablet (250 mg) three times daily. In case of menorrhagia: 500 mg three times daily with meals and from the onset of menses and continued according to the judgement of the physician. Children: 6 months to 1 year: 5 ml three times/day. 2-4 years: 10 ml three times/day. 5-8 years: 10 ml four times /day. 9-12 years: 15 ml four times/day. Treatment should not be continued for more than 7 days except on the advice of a physician.Interaction of HPR 250 mgAspirin: As other NSAIDs, concomitant administration of Mefenamic Acid and Aspirin is not generally recommended because of the potential of increased adverse effects.Warfarin: Mefenamic Acid can inhibit platelet aggregation and may prolong the prothrombin time in patients on warfarin therapyContraindicationsIt is contraindicated in patients with known hypersensitivity to Mefenamic Acid. It should not be used in patients with peptic ulcer, inflammatory bowel diseases, hepatic or renal impairment. It is also contraindicated in patients, whom aspirin and/or other NSAID's have induced symptoms of bronchospasm, skin rashes etc.Side Effects of HPR 250 mgThe most frequently reported adverse experiences occurring in approximately 1-10% of patients are gastrointestinal: abdominal pain, constipation, diarrhoea, dyspepsia, flatulence, nausea, Gl ulcers, vomiting, dizziness, abnormal renal function, pruritus, rashes.Pregnancy & LactationPregnancy: In late pregnancy, as with other NSAIDs, HPR 250 mg should be avoided because it may cause premature closure of the ductus arteriosus. In general there are no adequate and well controlled studies in pregnant women. HPR 250 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Rated as Pregnancy Category C.Lactation: Trace amounts of HPR 250 mg may be present in breast milk. Taking into account the importance of the drug to the mother , decision should be made whether to discontinue nursing or to discontinue the drug.Precautions & WarningsIt should be administered with caution in allergic diseases especially in asthma. The treatment should be withdrawn in diarrhoea, rashes, cholestatic jaundice, thrombocytopenia, haemolytic anaemia.Overdose Effects of HPR 250 mgSymptoms: Headache, nausea, vomiting, epigastric pain, GI bleeding. Rarely, diarrhoea, disorientation, excitation, coma, drowsiness, tinnitus, fainting, and occasionally convulsions. Management: Symptomatic and supportive treatment. In acute overdosage, empty the stomach immediately by inducing emesis or by gastric lavage followed by admin of activated charcoal.Storage ConditionsKeep away from light, store in a cool and dry place. Keep out of reach of children.Drug ClassesDrugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)Mode Of ActionHPR 250 mg contains Mefenamic Acid which is a nonsteroidal agent with demonstrated analgesic, anti-inflammatory and antipyretic activity due to its dual action on prostaglandins. It inhibits the enzymes of prostaglandin synthetase and also antagonizes the actions of prostaglandin at the receptor sites.PregnancyThe safety of HPR 250 mg on reproductive capacity and pregnancy has not been established. Thus, HPR 250 mg should be used in women of childbearing potential and during pregnancy only when the potential benefits are expected to outweigh the potential risks. Trace amounts of HPR 250 mg may be present in breast milk and transmitted to the nursing infant. Thus HPR 250 mg should not be taken by the nursing mother because of the effects of this class of drugs on the infant's cardiovascular system.