Afdol Oral SpecificationRequires Prescription (YES/NO)YesGenericsMemantine HydrochlorideUsed ForAlzheimerHow it worksThere is evidence that malfunctioning of glutamatergic neurotransmission, in particular at N-methyl-D-aspartate (NMDA)-receptors, contributes to both expression of symptoms and disease progression in neurodegenerative dementia. Memantine is a voltage-dependent, moderate-affinity uncompetitive NMDA-receptor antagonist. It blocks the effects of pathologically elevated tonic levels of glutamate that may lead to neuronal dysfunction .Afdol Oral Usage And SafetyDosageMemantine HydrochlorideSide EffectsCommon: Headache, sleepiness, constipation, elevated liver function test, dizziness, balance disorders, shortness of breath, high blood pressure and drug hypersensitivity ; Uncommon: Tiredness, fungal infections, confusion, hallucinations, vomiting, abnormal gait, heart failure and venous blood clotting (thrombosis/thromboembolism).Drug InteractionsL-dopa, dopaminergic agonists, and anticholinergics , antispasmodic medicines, dantrolene or baclofen , amantadine , cimetidine, ranitidine, procainamide, quinidine, quinine and nicotine , hydrochlorothiazide (HCT) , dextromorphan , oral anticoagulants .IndicationTreatment of patients with moderately severe to severe Alzheimer?s disease .When not to UseHypersensitivity to memantine hydrochloride or to any of the excipients . Children and adolescents below the age of 18 years, as safety and efficacy have not been established.Afdol Oral PrecautionsPrecautionBased on pharmacological considerations and single case reports, caution is recommended with patients suffering from epilepsy.Afdol Oral WarningsWarning 1Concomitant use of N-methyl-D-aspartate (NMDA)-antagonists such as amantadine, ketamine or dextromethorphan should be avoided. These medicines act at the same receptor system as this product and therefore adverse drug reactions (mainly CNS-related) may be more frequent or more pronounced .Warning 2In most clinical trials with Memantine, patients with recent myocardial infarction, congestive heart failure (NYHA III-IV) and uncontrolled hypertension were excluded. As a consequence only limited data are available and patients with these conditions should be closely supervised.Warning 3Moderately severe to severe Alzheimer?s disease usually causes impairment of driving performance and compromises the ability to use machinery. Furthermore, Memantine may change reactivity such that outpatients should be warned to take special care when driving a vehicle or operating machinery.Afdol Oral Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.
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Afdol Oral SpecificationRequires Prescription (YES/NO)YesGenericsMemantine HydrochlorideUsed ForAlzheimerHow it worksThere is evidence that malfunctioning of glutamatergic neurotransmission, in particular at N-methyl-D-aspartate (NMDA)-receptors, contributes to both expression of symptoms and disease progression in neurodegenerative dementia. Memantine is a voltage-dependent, moderate-affinity uncompetitive NMDA-receptor antagonist. It blocks the effects of pathologically elevated tonic levels of glutamate that may lead to neuronal dysfunction .Afdol Oral Usage And SafetyDosageMemantine HydrochlorideSide EffectsCommon: Headache, sleepiness, constipation, elevated liver function test, dizziness, balance disorders, shortness of breath, high blood pressure and drug hypersensitivity ; Uncommon: Tiredness, fungal infections, confusion, hallucinations, vomiting, abnormal gait, heart failure and venous blood clotting (thrombosis/thromboembolism).Drug InteractionsL-dopa, dopaminergic agonists, and anticholinergics , antispasmodic medicines, dantrolene or baclofen , amantadine , cimetidine, ranitidine, procainamide, quinidine, quinine and nicotine , hydrochlorothiazide (HCT) , dextromorphan , oral anticoagulants .IndicationTreatment of patients with moderately severe to severe Alzheimer?s disease .When not to UseHypersensitivity to memantine hydrochloride or to any of the excipients . Children and adolescents below the age of 18 years, as safety and efficacy have not been established.Afdol Oral PrecautionsPrecautionBased on pharmacological considerations and single case reports, caution is recommended with patients suffering from epilepsy.Afdol Oral WarningsWarning 1Concomitant use of N-methyl-D-aspartate (NMDA)-antagonists such as amantadine, ketamine or dextromethorphan should be avoided. These medicines act at the same receptor system as this product and therefore adverse drug reactions (mainly CNS-related) may be more frequent or more pronounced .Warning 2In most clinical trials with Memantine, patients with recent myocardial infarction, congestive heart failure (NYHA III-IV) and uncontrolled hypertension were excluded. As a consequence only limited data are available and patients with these conditions should be closely supervised.Warning 3Moderately severe to severe Alzheimer?s disease usually causes impairment of driving performance and compromises the ability to use machinery. Furthermore, Memantine may change reactivity such that outpatients should be warned to take special care when driving a vehicle or operating machinery.Afdol Oral Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.
