Cofrest Syrup SpecificationRequires Prescription (YES/NO)YesGenericsTheophylline , Diphenhydramine , Ammonium Chloride , Menthol Used ForFever & CoughHow it worksTheophylline?relaxes the smooth muscles located in the bronchial airways and pulmonary blood vessels. Ammonium chloride increases acidity by increasing the amount of hydrogen ion concentrations. Ammonium chloride can be used as an expectorant due to its irritative action on the bronchial mucosa. It acts as a counter- irritant by imparting a cooling effect and by initially stimulating nociceptors and then desensitizing them.Diphenhydramine acts as an inverse agonist at the H1 receptor, thereby reversing the effects of histamine on capillaries, reducing allergic reaction symptoms.Cofrest Syrup Usage And SafetyDosageTheophylline , Diphenhydramine , Ammonium Chloride , Menthol Side EffectsHypersensitivity , Hypokalaemia, hyperglycaemia, electrolyte imbalance , Agitation, restlessness, irritability, nervousness , Headache, insomnia, tremor, convulsions , Heart rate increased, heart rate irregular, palpitations, arrhythmia, ventricular , arrhythmia, tachycardia, sinus tachycardia, supraventricular tachycardia, atrial tachycardia and atria flutter , Hypotension, shock , Nausea, vomiting, diarrhoea, gastrointestinal disorder including gastrointestinal haemorrhage, abdominal pain, haematemesis.Drug InteractionsAlcohol , Allopurinol , Aminoglutethimide , Barbiturates , Diazepam , Cimetidine , Disulfiram , Erythromycin , Estrogen , Fluvoxamine , Formoterol , Halothane , Imipenem , Isoniazid , Lithium , Macrolides (josamycin,spiramycin) Methotrexate (MTX) , Mexiletine , Moricizine , Pentoxifylline , Phenobarbital , Phenytoin ,Primidone , Propafenone , Propranolol , Rifampin , Sulfinpyrazone , Tacrine , Thiabendazole , Ticlopidine, Troleandomycin , Verapamil , Zileuton.Indication Reversible airflow obstruction, Relief of runny nose, Sneezing, Itchy, Watery eyes, Itchy nose, Itchy throat due to hay fever or allergy.When not to UseHypersensitivity to the ingredients listed.Cofrest Syrup PrecautionsPrecautionTheophylline should be used with caution and only if absolutely necessary in the following cases: Unstable angina , Patients at risk of tachyarrhythmia , Severe hypertension , Hypertrophic obstructive cardiomyopathy , Hyperthyroidism.Cofrest Syrup WarningsWarning 1Patients administering Ammonium chloride should be watched to the signs of ammonia toxicity.Warning 2Diphenhydramine may make you dizzy and can blur vision.Warning 3Theophylline should be used with caution in patients with hepatic or renal function impairment.Cofrest Syrup Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.
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Cofrest Syrup SpecificationRequires Prescription (YES/NO)YesGenericsTheophylline , Diphenhydramine , Ammonium Chloride , Menthol Used ForFever & CoughHow it worksTheophylline?relaxes the smooth muscles located in the bronchial airways and pulmonary blood vessels. Ammonium chloride increases acidity by increasing the amount of hydrogen ion concentrations. Ammonium chloride can be used as an expectorant due to its irritative action on the bronchial mucosa. It acts as a counter- irritant by imparting a cooling effect and by initially stimulating nociceptors and then desensitizing them.Diphenhydramine acts as an inverse agonist at the H1 receptor, thereby reversing the effects of histamine on capillaries, reducing allergic reaction symptoms.Cofrest Syrup Usage And SafetyDosageTheophylline , Diphenhydramine , Ammonium Chloride , Menthol Side EffectsHypersensitivity , Hypokalaemia, hyperglycaemia, electrolyte imbalance , Agitation, restlessness, irritability, nervousness , Headache, insomnia, tremor, convulsions , Heart rate increased, heart rate irregular, palpitations, arrhythmia, ventricular , arrhythmia, tachycardia, sinus tachycardia, supraventricular tachycardia, atrial tachycardia and atria flutter , Hypotension, shock , Nausea, vomiting, diarrhoea, gastrointestinal disorder including gastrointestinal haemorrhage, abdominal pain, haematemesis.Drug InteractionsAlcohol , Allopurinol , Aminoglutethimide , Barbiturates , Diazepam , Cimetidine , Disulfiram , Erythromycin , Estrogen , Fluvoxamine , Formoterol , Halothane , Imipenem , Isoniazid , Lithium , Macrolides (josamycin,spiramycin) Methotrexate (MTX) , Mexiletine , Moricizine , Pentoxifylline , Phenobarbital , Phenytoin ,Primidone , Propafenone , Propranolol , Rifampin , Sulfinpyrazone , Tacrine , Thiabendazole , Ticlopidine, Troleandomycin , Verapamil , Zileuton.Indication Reversible airflow obstruction, Relief of runny nose, Sneezing, Itchy, Watery eyes, Itchy nose, Itchy throat due to hay fever or allergy.When not to UseHypersensitivity to the ingredients listed.Cofrest Syrup PrecautionsPrecautionTheophylline should be used with caution and only if absolutely necessary in the following cases: Unstable angina , Patients at risk of tachyarrhythmia , Severe hypertension , Hypertrophic obstructive cardiomyopathy , Hyperthyroidism.Cofrest Syrup WarningsWarning 1Patients administering Ammonium chloride should be watched to the signs of ammonia toxicity.Warning 2Diphenhydramine may make you dizzy and can blur vision.Warning 3Theophylline should be used with caution in patients with hepatic or renal function impairment.Cofrest Syrup Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.