Etoroid Tablets SpecificationRequires Prescription (YES/NO)YesGenericsEtoricoxibUsed ForOsteoarthritisHow it worksEtoricoxib is an oral, selective cyclo-oxygenase-2 (COX-2) inhibitor. Etoricoxib produced dose-dependent inhibition of COX-2 without inhibition of COX-1 at doses up to 150mg daily. Etoricoxib does not inhibit gastric prostaglandin synthesis and has no effect on platelet function. Selective inhibition of COX-2 by etoricoxib decreases the synthesis of prostanoid mediators of pain, inflammation and fever with decreased potential for GI toxicity and effects on platelet aggregation.Etoroid Tablets Usage And SafetyDosageEtoricoxibSide EffectsCommon : Alveolar osteitis, edema/fluid retention, dizziness, headache, palpitations, arrhythmia, hypertension, bronchospasm, constipation, flatulence, gastritis, acid reflux, diarrhea, dyspepsia, epigastric discomfort, nausea, vomiting, ALT increased, AST increased, ecchymosis, asthenia/fatigue and flu-like disease.Uncommon : Gastroenteritis, upper respiratory infection, urinary tract infection, anemia, leukopenia, thrombocytopenia, hypersensitivity, increase or decrease appetite,weight gain, anxiety, depression, mental acuity decreased, hallucinations, dysgeusia, insomnia, paresthaesia/hypaesthesia, somnolence, blurred vision, conjunctivitis, tinnitus, vertigo, atrial fibrillation, tachycardia, congestive heart failure, non-specific ECG changes, angina pectoris, myocardial infarction, flushing, cerebrovascular accident, transient ischemic attack, hypertensive crisis, vasculitis, cough, dyspnea, epistaxis, abdominal distention, bowel movement pattern change, constipation, dry mouth, gastroduodenal ulcer, peptic ulcer, irritable bowel syndrome, pancreatitis, facial edema, pruritus, rash, erythema, urticaria, muscular cramp/spasm, musculoskeletal pain/stiffness,proteinuria, serum creatinine increased, renal failure/renal insufficiency, chest pain, blood urea nitrogen increased, creatine phosphokinase increased, hyperkalemia and uric acid increased.Rare : Angioedema/anaphylactic/anaphylactoid reactions including shock, confusion, restlessness, hepatitis, hepatic failure, jaundice, Stevens-Johnson syndrome, toxic epidermal necrolysis, fixed drug eruption and blood sodium decreased.Drug InteractionsOral anticoagulants , Diuretics, ACE inhibitors and Angiotensin II antagonists , Acetylsalicylic Acid , Ciclosporin and Tacrolimus , Lithium , Methotrexate , Oral contraceptives , Hormone Replacement Therapy (HRT) , Digoxin , Sulfotransferases , Rifampicin.IndicationEtoricoxib is indicated for:- Symptomatic relief of osteoarthritis (OA) and rheumatoid arthritis (RA)- The management of ankylosing spondylitis (AS)- Treatment of acute gouty arthritis- Relief of acute pain - Relief of chronic musculoskeletal pain- Treatment of primary dysmenorrhea- Treatment of moderate to severe acute post-operative pain associated with dental surgery- Treatment of moderate to severe acute post-operative pain associated with abdominal gynecological surgery .When not to UseEtoricoxib is contraindicated in:- Hypersensitivity to active substance or to any of the excipient of the product.- Active peptic ulceration or active gastrointestinal (GI) bleeding.- Patients who have experienced bronchospasm, acute rhinitis, nasal polyps, angioneurotic edema, urticaria or allergic-type reactions after taking acetylsalicylic acid or NSAIDs including COX-2 (cyclooxygenase-2) inhibitors.- Severe hepatic dysfunction (serum albumin <25 g/L or Child-Pugh score = 10).- Estimated renal creatinine clearance < 30mL/min.- Children and adolescents under 16 years of age.- Inflammatory bowel disease.- Congestive heart failure (NYHA II-IV).- Patients with hypertension whose blood pressure is persistently elevated above 140/90mmHg and has not been adequately controlled.- Established ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease.Etoroid Tablets PrecautionsPrecautionCaution is advised with treatment of patients most at risk of developing a gastrointestinal complication with NSAIDs; the elderly, patients using any other NSAID or acetylsalicylic acid concomitantly or patients with a prior history of gastrointestinal disease, such as ulceration and GI bleeding.Etoroid Tablets WarningsWarning 1Patients with significant risk factors for cardiovascular events (e.g., hypertension, hyperlipidemia, diabetes mellitus, smoking) should only be treated with etoricoxib after careful consideration.Warning 2COX-2 selective inhibitors are not a substitute for acetylsalicylic acid for prophylaxis of cardiovascular thrombo-embolic diseases because of their lack of antiplatelet effect. Therefore antiplatelet therapies should not be discontinued.Warning 3In compromised renal perfusion, administration of etoricoxib may cause a reduction in prostaglandin formation and secondarily, in renal blood flow and thereby impair renal function. Monitoring of renal function in such patients should be considered.Etoroid Tablets Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.
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Etoroid Tablets SpecificationRequires Prescription (YES/NO)YesGenericsEtoricoxibUsed ForOsteoarthritisHow it worksEtoricoxib is an oral, selective cyclo-oxygenase-2 (COX-2) inhibitor. Etoricoxib produced dose-dependent inhibition of COX-2 without inhibition of COX-1 at doses up to 150mg daily. Etoricoxib does not inhibit gastric prostaglandin synthesis and has no effect on platelet function. Selective inhibition of COX-2 by etoricoxib decreases the synthesis of prostanoid mediators of pain, inflammation and fever with decreased potential for GI toxicity and effects on platelet aggregation.Etoroid Tablets Usage And SafetyDosageEtoricoxibSide EffectsCommon : Alveolar osteitis, edema/fluid retention, dizziness, headache, palpitations, arrhythmia, hypertension, bronchospasm, constipation, flatulence, gastritis, acid reflux, diarrhea, dyspepsia, epigastric discomfort, nausea, vomiting, ALT increased, AST increased, ecchymosis, asthenia/fatigue and flu-like disease.Uncommon : Gastroenteritis, upper respiratory infection, urinary tract infection, anemia, leukopenia, thrombocytopenia, hypersensitivity, increase or decrease appetite,weight gain, anxiety, depression, mental acuity decreased, hallucinations, dysgeusia, insomnia, paresthaesia/hypaesthesia, somnolence, blurred vision, conjunctivitis, tinnitus, vertigo, atrial fibrillation, tachycardia, congestive heart failure, non-specific ECG changes, angina pectoris, myocardial infarction, flushing, cerebrovascular accident, transient ischemic attack, hypertensive crisis, vasculitis, cough, dyspnea, epistaxis, abdominal distention, bowel movement pattern change, constipation, dry mouth, gastroduodenal ulcer, peptic ulcer, irritable bowel syndrome, pancreatitis, facial edema, pruritus, rash, erythema, urticaria, muscular cramp/spasm, musculoskeletal pain/stiffness,proteinuria, serum creatinine increased, renal failure/renal insufficiency, chest pain, blood urea nitrogen increased, creatine phosphokinase increased, hyperkalemia and uric acid increased.Rare : Angioedema/anaphylactic/anaphylactoid reactions including shock, confusion, restlessness, hepatitis, hepatic failure, jaundice, Stevens-Johnson syndrome, toxic epidermal necrolysis, fixed drug eruption and blood sodium decreased.Drug InteractionsOral anticoagulants , Diuretics, ACE inhibitors and Angiotensin II antagonists , Acetylsalicylic Acid , Ciclosporin and Tacrolimus , Lithium , Methotrexate , Oral contraceptives , Hormone Replacement Therapy (HRT) , Digoxin , Sulfotransferases , Rifampicin.IndicationEtoricoxib is indicated for:- Symptomatic relief of osteoarthritis (OA) and rheumatoid arthritis (RA)- The management of ankylosing spondylitis (AS)- Treatment of acute gouty arthritis- Relief of acute pain - Relief of chronic musculoskeletal pain- Treatment of primary dysmenorrhea- Treatment of moderate to severe acute post-operative pain associated with dental surgery- Treatment of moderate to severe acute post-operative pain associated with abdominal gynecological surgery .When not to UseEtoricoxib is contraindicated in:- Hypersensitivity to active substance or to any of the excipient of the product.- Active peptic ulceration or active gastrointestinal (GI) bleeding.- Patients who have experienced bronchospasm, acute rhinitis, nasal polyps, angioneurotic edema, urticaria or allergic-type reactions after taking acetylsalicylic acid or NSAIDs including COX-2 (cyclooxygenase-2) inhibitors.- Severe hepatic dysfunction (serum albumin <25 g/L or Child-Pugh score = 10).- Estimated renal creatinine clearance < 30mL/min.- Children and adolescents under 16 years of age.- Inflammatory bowel disease.- Congestive heart failure (NYHA II-IV).- Patients with hypertension whose blood pressure is persistently elevated above 140/90mmHg and has not been adequately controlled.- Established ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease.Etoroid Tablets PrecautionsPrecautionCaution is advised with treatment of patients most at risk of developing a gastrointestinal complication with NSAIDs; the elderly, patients using any other NSAID or acetylsalicylic acid concomitantly or patients with a prior history of gastrointestinal disease, such as ulceration and GI bleeding.Etoroid Tablets WarningsWarning 1Patients with significant risk factors for cardiovascular events (e.g., hypertension, hyperlipidemia, diabetes mellitus, smoking) should only be treated with etoricoxib after careful consideration.Warning 2COX-2 selective inhibitors are not a substitute for acetylsalicylic acid for prophylaxis of cardiovascular thrombo-embolic diseases because of their lack of antiplatelet effect. Therefore antiplatelet therapies should not be discontinued.Warning 3In compromised renal perfusion, administration of etoricoxib may cause a reduction in prostaglandin formation and secondarily, in renal blood flow and thereby impair renal function. Monitoring of renal function in such patients should be considered.Etoroid Tablets Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.
