Thewril Capsules SpecificationRequires Prescription (YES/NO)Yes GenericsThiocolchicosideUsed ForMuscle SpasmsHow it worksThiocolchicoside has a selective and potent af?nity for g-aminobutyric acid A (GABA-A) receptors and?acts on muscular contractures by activating the GABA inhibitory pathways?thereby behaving as a potent muscle relaxant .Thewril Capsules Usage And SafetyDosageThiocolchicosideSide EffectsGenerally the drugs is well-tolerated. In rare cases diarrhea, gastric pain and heartburn may occur. In very rare cases, drowsiness may also occur infrequent cases of skin rash or erythema have been reported.Drug InteractionsTaking Thiocolchicoside with other drugs which acting muscle relaxants on the musculoskeletal system are not recommended because they may enhance the effect of another .IndicationAs an adjuvant treatment in painful spasm associated with degenerative vertebral disorders and vertebral static problem, torticollis, dorsal pain, low back pain, traumatological and neurological disorders.When not to UseHypersensitivity to thiocolchicoside or one of its excipients; pregnancy and lactation; in women of child bearing potential not using effective contraceptive.Thewril Capsules PrecautionsPrecautionIf diarrhea appears after oral administration the dosage should be reduced.Thewril Capsules WarningsWarning 1In preclinical studies, one of thiocolchicoside metabolites induced aneuploidy at concentrations close to human exposure observed at doses 8 mg twice daily. Aneuploidy is reported as a risk factor for teratogenicity, embryofoetotoxicity/spontaneous abortion, cancer, and impaired male fertility. As a precautionary measure, use of the product at doses exceeding the recommended dose or long term use should be avoided.Warning 2Postmarketing cases of cytolytic and cholestatic hepatitis have been reported. Severe cases in patients concomitantly taking NSAIDs or paracetamol. Patients should be advised to stop treatment and report any sign of liver toxicity.Warning 3Thiocolchicoside may precipitate seizures, especially in patients with epilepsy or those at risk for seizures. Patients should be carefully informed about the potential risk of a possible pregnancy and about effective contraceptive measures to be followed.Thewril Capsules Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.
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Thewril Capsules SpecificationRequires Prescription (YES/NO)Yes GenericsThiocolchicosideUsed ForMuscle SpasmsHow it worksThiocolchicoside has a selective and potent af?nity for g-aminobutyric acid A (GABA-A) receptors and?acts on muscular contractures by activating the GABA inhibitory pathways?thereby behaving as a potent muscle relaxant .Thewril Capsules Usage And SafetyDosageThiocolchicosideSide EffectsGenerally the drugs is well-tolerated. In rare cases diarrhea, gastric pain and heartburn may occur. In very rare cases, drowsiness may also occur infrequent cases of skin rash or erythema have been reported.Drug InteractionsTaking Thiocolchicoside with other drugs which acting muscle relaxants on the musculoskeletal system are not recommended because they may enhance the effect of another .IndicationAs an adjuvant treatment in painful spasm associated with degenerative vertebral disorders and vertebral static problem, torticollis, dorsal pain, low back pain, traumatological and neurological disorders.When not to UseHypersensitivity to thiocolchicoside or one of its excipients; pregnancy and lactation; in women of child bearing potential not using effective contraceptive.Thewril Capsules PrecautionsPrecautionIf diarrhea appears after oral administration the dosage should be reduced.Thewril Capsules WarningsWarning 1In preclinical studies, one of thiocolchicoside metabolites induced aneuploidy at concentrations close to human exposure observed at doses 8 mg twice daily. Aneuploidy is reported as a risk factor for teratogenicity, embryofoetotoxicity/spontaneous abortion, cancer, and impaired male fertility. As a precautionary measure, use of the product at doses exceeding the recommended dose or long term use should be avoided.Warning 2Postmarketing cases of cytolytic and cholestatic hepatitis have been reported. Severe cases in patients concomitantly taking NSAIDs or paracetamol. Patients should be advised to stop treatment and report any sign of liver toxicity.Warning 3Thiocolchicoside may precipitate seizures, especially in patients with epilepsy or those at risk for seizures. Patients should be carefully informed about the potential risk of a possible pregnancy and about effective contraceptive measures to be followed.Thewril Capsules Additional InformationPregnancy categoryAlways consult your physician before using any medicine.Storage (YES/NO)Store this medicine at room temperature, away from direct light and heat.
