Actemra 400mg Injection 1?S Allschoolabs -

Specification

INTRODUCTION
ACTEMRA 400MG contains Tocilizumab which belongs to aroup of medicines called interleukin-6 (IL-6) receptor inhibitors. It treats rheumatoid arthritis,iant cell arteritis (GCA), active systemic juvenile idiopathic arthritis (sJIA) and polyarticular juvenile idiopathic arthritis (pJIA). This medicine also indicated for severe or life-threatening cytokine release syndrome (CRS) following chimeric antigen receptor (CAR) T-cell treatment.
Tocilizumab is an anti-human interleukin 6 (IL-6) receptor monoclonal antibody of the immunoglobulin (Ig) which blocks a cytokine called IL-6 which is found at high levels in the joints affected by rheumatoid arthritis. Before receiving ACTEMRA 400MG, tell your physician if you have liver, kidney or heart problems, are pregnant or breastfeeding. This medicine is not suitable for use in children below 2 years of age. The common side effects are nausea, headache and dizziness.
USES OF ACTEMRA 400MG
Treats,
Rheumatoid arthritis

Giant cell arteritis (GCA)

Active systemic juvenile idiopathic arthritis (sJIA)

Polyarticular juvenile idiopathic arthritis (pJIA) and

Severe or life-threatening cytokine release syndrome (CRS) following chimeric antigen receptor (CAR) T-cell treatment

HOW ACTEMRA 400MG WORKS
Tocilizumab blocks the action of interleukin-6, a substance in the body which causes inflammation. By blocking the immune system?s attack on normal tissues, it reduces pain, joint inflammation and tiredness leading to a better quality of life.
DIRECTIONS FOR USE
ACTEMRA 400MG will be administered by your doctor or nurse by intravenously or subcutaneously. Your physician will administer the right dose depends on your health condition.
SIDE EFFECTS OF ACTEMRA 400MG

SERIOUS

Breathing difficulty or light-headedness

Rash, itching, hives, swelling of the lips

Chest pain

Yellow skin or eyes, dark brown coloured urine, pain or swelling in the upper right side of the stomach area

COMMON

Common cold

Sinus infections

Headaches

Increase or decrease in blood pressure

Nausea

Dizziness

Reactions at the injection site

HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and drink plenty of fluids. Apply a wet or cold cloth to forehead and rest in a quiet, comfortable, dark room.
Dizziness:
Get up and move around to feel awake and eat a healthy food to boost your energy.
?Nausea:
Take normal regular meals and do not eat spicy foods.
WARNING & PRECAUTIONS

PREGNANCY
ACTEMRA 400MG should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor for advice.
BREASTFEEDING
ACTEMRA 400MG should be used with caution during breastfeeding. Consult your doctor for advice.
DRIVING AND USING MACHINES
Do not drive or operate any machines while taking this medicine, since it may cause dizziness.
LIVER
ACTEMRA 400MG is not recommended in patients with hepatitis or active liver diseases. Consult your doctor for advice.
ALLERGY
Tell your doctor if you are allergic (hypersensitive) to Tocilizumab.
HEART DISEASE
ACTEMRA 400MG should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.
OTHERS
Tell your doctor before taking this medicine if you have or had:
Active infection

Tuberculosis

Diabetes

HIV/AIDS or a weaker immune system

Multiple sclerosis

History of macrophage activating syndrome (MAS)

Abdominal pain

Stomach, pancreas or bowel (intestine) problems or pancreatitis

High blood pressure

Increase in cholesterol

Any type of cancer

Are scheduled to have surgery

INTERACTIONS
Tell your doctor if you are taking,
Simvastatin, atorvastatin (treats cholesterol)

Calcium channel blockers

Theophylline (treats breathing problems)

Warfarin, phenytoin (treats epilepsy)

Ciclosporin (prevent organ rejection)

Benzodiazepines (treats anxiety)

SYNOPSIS

Drug :?? Tocilizumab

Pharmacological Category :?? Antirheumatic, Disease Modifying?Interleukin-6 Receptor Antagonist

Therapeutic Indication :?? Cytokine release syndrome,iant cell arteritis,?Polyarticular juvenile idiopathic arthritis, Rheumatoid arthritis,?Polyarticular juvenile idiopathic arthritis, Rheumatoid arthritis

Dosage Forms :?? Injection

MORE INFORMATION

Keep out of reach of children

Store at 2-8?C

FAQs ABOUT ACTEMRA 400MG
How does ACTEMRA 400MG work?
It works by blocking the inflammatory effects of a protein called tumor necrosis factor alpha (TNF?) in RA and other conditions associated with inflammation.
Is ACTEMRA 400MG over the counter?
No, it is available with doctor?s prescription only.
How is ACTEMRA 400MG administered?
It is administered by intravenous or subcutaneous injection by your doctor or nurse.
REFERENCES
1. Vicki Oldfield, Sohita Dhillon,reg L Plosker. Tocilizumab: a review of its use in the management of rheumatoid arthritis. 2009. [Accessed on June 11, 2021] https://pubmed.ncbi.nlm.nih.gov/19368420/
2. Hoffmann-La Roche Limited Mississauga. [Revised on Jan 04, 2021] [Accessed on June 11, 2021]?https://www.rochecanada.com/PMs/Actemra/Actemra_PM_E.pdf
3. Cipla Ltd. 29 Aug 2008. [Revised on July 2020] [Accessed on June 11, 2021]?https://www.ciplamed.com/print-product-pdf/46820
4. Pan Luo, Yi Liu, 1 Lin Qiu, 1 Xiulan Liu, 1 Dong Liu and Juan Li. Tocilizumab treatment in COVID-19: A single center experience. April 15, 2020. [Accessed on June 11, 2021]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262125/
USEFUL DIAGNOSTIC TESTS

Anti Neutrophilic Cytoplasmic Antibody ? P

Anti Saccharomyces Cerevisiae (ASCA), IgA

Anti Saccharomyces Cerevisiae (ASCA), IgG

C- Reactive Protein Quantitative

Erythrocyte Sedimentation Rate

HLA ? B27, PCR

Rheumatoid Factor ? Agglutination

Rheumatoid Factor ? Turbidometry

Rheumatoid Factor IgG Antibody

PRODUCT DETAILS

Net Qty

1 N