Advantec 16-12.5mg Tablet?and?Hydrochlorothiazide (Advantec 16-12.5mg Tablet) combination is used to treat high blood pressure (hypertension). This medication is used for lowering blood pressure in hypertensive (increased blood pressure) patients and for treating edema (excess fluid in the body) associated with heart disease. It can also be used to treat Nephrotic Syndrome.