AMPHOTIN LIP 50mg Injection 1?s Allschoolabs -

Description

INTRODUCTION
AMPHOTIN LIP 50MG contains Amphotericin B which belongs to a group of medicines known as anti-fungal antibiotics. It is indicated for severe life threatening fungal infections and visceral leishmaniasis (developed by parasite).
Amphotericin B is an antifungal medicine, which can be fungistatic or fungicidal, depends on its concentration and fungal susceptibility, which acts by binding to ergosterol in the fungal cell membrane eventually causes membrane damage.? This results in cell contents leak from the fungal cell and cell death happens. It has greater affinity for fungal ergosterol than for the cholesterol of human cells. Amphotericin B is a macrocyclic which is created from a strain of Streptomyces nodosus.
AMPHOTIN LIP 50MG will be administered by physician or nurse, inform your physician if you have or had liver, kidney or heart problems, are pregnant women or breastfeeding mothers. This medicine is not suitable for babies less than 1 month old. The common side effects are nausea, vomiting, fever, chills and decrease in potassium levels.
USES OF AMPHOTIN LIP 50MG

Treats severe life threatening fungal infections and Leishmaniasis

HOW AMPHOTIN LIP 50MG WORKS
Amphotericin B works by slowing the growth of fungi that causes infection.
DIRECTIONS FOR USE
AMPHOTIN LIP 50MG will be administered as an infusion into a vein (drip) by physician or nurse.
SIDE EFFECTS OF AMPHOTIN LIP 50MG

COMMON

Fever, chills

Decrease in blood potassium levels

Nausea or vomiting

Increase in blood sugar levels

Headache

Fast heart rate

Decrease in blood pressure and flushing

Breathlessness

Diarrhoea

Stomach pain

Rash

Chest and back pain

Abnormal liver or kidney test results

HOW TO MANAGE SIDE EFFECTS
Nausea:
Stick to regular meals and avoid spicy foods.
Diarrhoea:
Take large amount of fluids to avoid dehydration. ORS can also be used to prevent dehydration.
Vomiting:
Drink ice-cold drinks and eat light foods and avoid sweets.
Abdominal pain:
Place a warm water bottle on your abdomen or soak in a warm bath. Drink sufficient amount of water.
Headache:
Rest in a quiet, comfortable, and dark room with a cold or wet cloth on your temple.
WARNING & PRECAUTIONS

PREGNANCY
AMPHOTIN LIP 50MG should be used with caution in pregnant women. Consult your doctor before taking this medicine.
BREASTFEEDING
AMPHOTIN LIP 50MG should be used with caution in breastfeeding mothers. Consult your doctor before taking this medicine.
DRIVING AND USING MACHINES
Do not drive or operate any machines, AMPHOTIN LIP 50MG could affect your ability to drive or use machines safely.
KIDNEY
AMPHOTIN LIP 50MG should be used with caution if you are suffering from kidney failure or undergoing dialysis. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic (hypersensitive) to Amphotericin B.
OTHERS
Tell your physician if you have or had a condition, such as,
Severe allergic reaction (anaphylactic or anaphylactoid)

Low potassium levels

White blood cell transfusion

Diabetes

INTERACTIONS
Tell your doctor if you are taking,
Ciclosporin and tacrolimus (suppress the immune system)

Gentamicin, neomycin, streptomycin and polymixin (treats infection)

Pentamidine (treats pneumonia along with AIDS and leishmaniasis)

Corticosteroids

Corticotropin (controls the amount of corticosteroid produced by your body)

Furosemide ?

Digitalis glycosides (treats heart failure)

Tubocurarine ?

Flucytosine (treats fungal infection)

Methotrexate, doxorubicin, carmustine and cyclophosphamide (treats cancer)

White blood cell transfusions

SYNOPSIS

Drug :?? Amphotericin B

Pharmacological Category :?? Antifungal Agent

Therapeutic Indication :?? Life-threatening fungal infections, Leishmaniasis

Dosage Forms :?? Injection, Topical gel

MORE INFORMATION
Store at?2 ? 8?C and keep out of reach of children.
FAQs ABOUT AMPHOTIN LIP 50MG
How long will?it take AMPHOTIN LIP 50MG?to be administered?
It usually takes 30 to 60 minutes. In case of high doses it may take up to 2 hours.
Does AMPHOTIN LIP 50MG a?fungicidal?
Yes, this medicine is fungicidal in nature, which kills the fungi.
Is AMPHOTIN LIP 50MG?testing dose needed?
Yes, testing dose is needed, to check if you have any allergic condition before starting the treatment.
REFERENCES
1. KD Tripathi MD. General considerations. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page ? 689.
2. Phillips MA, Stanley SL Jr. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman?s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page ??1424.
3. Bennett JE. Antifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman?s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. Page: 1571-1575.
4. Sheppard D, Lampiris HW. Antifungal Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page: 836-838.
5. Neil RH Stone, Tihana Bicanic, Rahuman Salim, and William Hope. Liposomal Amphotericin B: A review of the pharmacokinetics, pharmacodynamics, clinical experience and future directions. March, 2016. [Accessed May 25, 2021]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856207/
6. Gilead Sciences International Ltd. Electronic Medicines Compendium (EMC); [Revised Sep, 2020] [Accessed May 25, 2021]?https://www.medicines.org.uk/emc/files/pil.1022.pdf
7. Teva Pharma B.V. Millmount Healthcare Limited. Electronic Medicines Compendium (EMC); [Revised Dec, 2020] [Accessed May 25, 2021]?https://www.medicines.org.uk/emc/files/pil.5407.pdf
8. Cipla. [Revised Sep, 2013] [Accessed May 25, 2021]?https://www.ciplamed.com/content/phosome-injection
USEFUL DIAGNOSTIC TESTS