INTRODUCTION
AMTERICIN 50MG INJECTION contains Amphotericin B which belongs to the group of medicines called Anti-fungal agents. AMTERICIN 50MG INJECTION is used to treat invasive fungal infections in patients who are resistant/intolerant to conventional Amphotericin B therapy.
AMTERICIN 50MG INJECTION is not recommended for use in patients allergic to Amphotericin B. It is also not recommended for use in patients with common/superficial, clinically inapparent fungal infections (which are detectable only by positive skin/serologic tests).
Before receiving AMTERICIN 50MG INJECTION, inform your doctor if you are neutropenic, and/or have liver problems (such as hepatic impairment), and suffer from kidney problems/undergoing dialysis.
AMTERICIN 50MG INJECTION should be used with caution in pregnant and breast-feeding women only if it is clearly necessary. It is also used with caution in children and adolescents (aged below 18 years) and in elders (aged above 65 years) after consulting with the doctor.
The most common side effects of receiving AMTERICIN 50MG INJECTION are fever, chills, and/or rigors. Consult your doctor if any of these symptoms worsen.
USES OF AMTERICIN 50MG INJECTION

Treats invasive fungal infections in patients who are resistant/intolerant to conventional Amphotericin B therapy

HOW AMTERICIN 50MG INJECTION WORKS
AMTERICIN 50MG INJECTION binds to ergosterol (steroid present on the cell membranes of fungi) which leads to the formation of pores and ion leakage on the cell membrane resulting in fungal cell death thus treating invasive fungal infections in affected individuals.
DIRECTIONS FOR USE
AMTERICIN 50MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF AMTERICIN 50MG INJECTION

COMMON

Fever

Chills/rigors

WARNING & PRECAUTIONS

PREGNANCY
AMTERICIN 50MG INJECTION should be administered with caution in pregnant women only if it is clearly necessary. Consult your doctor before receiving the medicine.
BREASTFEEDING
AMTERICIN 50MG INJECTION should be administered with caution in breastfeeding women only if it is clearly necessary. Consult your doctor before receiving the medicine.
DRIVING AND USING MACHINES
AMTERICIN 50MG INJECTION is unlikely to affect your ability to drive/operate machines. ?Consult your doctor before receiving AMTERICIN 50MG INJECTION.
KIDNEY
AMTERICIN 50MG INJECTION should be administered with caution in patients with kidney disease and in patients who are under dialysis. ?Consult your doctor before receiving the medicine.
LIVER
AMTERICIN 50MG INJECTION should be administered with caution in patients with hepatic impairment, and/or other liver disease. Consult your doctor before receiving AMTERICIN 50MG INJECTION.
ALLERGY
Do not receive AMTERICIN 50MG INJECTION if you are allergic to Amphotericin B, and/or any other ingredients of this medicine.
OTHERS
AMTERICIN 50MG INJECTION is not recommended for use if you:
Have common/superficial, clinically inapparent fungal infections (which are detectable only by positive skin/serologic tests)
Before receiving AMTERICIN 50MG INJECTION, inform your doctor if you:
Suffer from neutropenia (condition marked by low count of neutrophils)
Use in Pediatrics:
AMTERICIN 50MG INJECTION should be used with caution in children and adolescents (aged below 18 years). Consult your doctor before child receives the medicine.
Use in Geriatrics:
AMTERICIN 50MG INJECTION should be used with caution in elderly patients (aged above 65 years). Consult your doctor before receiving AMTERICIN 50MG INJECTION.
INTERACTIONS
A. Drug?Drug interactions:
Before receiving AMTERICIN 50MG INJECTION, inform your doctor if you are taking any of the following medicine:
Nephrotoxic drugs (medicines that can cause damage to the kidney) Ex. minoglycosides, cisplatin

Zidovudine (used to treat HIV)

Cyclosporin (used to treat transplanted organ rejection)
Overdosage:
AMTERICIN 50MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
SYNOPSIS

Drug :?? Amphotericin B

Pharmacological Category :?? Anti-fungal agent

Therapeutic Indication :?? Invasive fungal infection? ? ? ? ?

Dosage Forms :?? Injection, Infusion, Emulsion, Gel

MORE INFORMATION

Keep AMTERICIN 50MG INJECTION out of reach of children

Store AMTERICIN 50MG INJECTION under refrigeration at 2?C to 8?C

FAQs ABOUT AMTERICIN 50MG INJECTION
What is AMTERICIN 50MG INJECTION used for?
AMTERICIN 50MG INJECTION is an anti-fungal agent which is used to treat invasive fungal infections in patients who are resistant/intolerant to conventional Amphotericin B therapy.
What are the side effects of AMTERICIN 50MG INJECTION?
The most common side effects of receiving AMTERICIN 50MG INJECTION are fever, chills, and/or rigors. Consult your doctor if any of these symptoms worsen.
How AMTERICIN 50MG INJECTION works:
AMTERICIN 50MG INJECTION binds to ergosterol (steroid present on the cell membranes of fungi) which leads to the formation of pores and ion leakage on the cell membrane resulting in fungal cell death thus treating invasive fungal infections in affected individuals.
How AMTERICIN 50MG INJECTION is administered?
AMTERICIN 50MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Can AMTERICIN 50MG INJECTION be used in pregnant and breast-feeding women?
Yes, AMTERICIN 50MG INJECTION can be administered but with caution in pregnant and breastfeeding women. Consult your doctor before receiving the medicine.
REFERENCES
1. KD. Tripathi. Anti-Fungal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page ? 787.
2.?Neil RH Stone, Tihana Bicanic, Rahuman Salim and William Hope. Liposomal Amphotericin B (AmBisome?): A review of the pharmacokinetics, pharmacodynamics, clinical experience and future directions. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. March 2017. [Accessed on 12th May 2022]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856207/
3.?Satomi Ueda, Shunichi Miyamoto, Kosuke Kaida, Aki Chizuka, Rie Kojima, Junichiro Takano, Toshie Ogasawara, Ko Miyamoto, Shigesaburo Miyakoshi, Yoshinobu Kanda. Safety and efficacy of treatment with liposomal amphotericin B in elderly patients at least 65 years old with hematological diseases. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. May 2016. [Accessed on 12th May 2022] https://pubmed.ncbi.nlm.nih.gov/26908230/
4.?Bharat Serums and Vaccines Limited.?Ampholip. [Accessed on 12th May 2022]?https://bsvgroup.com/assets/pdf/products/AMPHOLIP-Common-Pack-Insert-Export-for-Domestic.pdf
USEFUL DIAGNOSTIC TESTS

Fungal culture test

Net Qty

1 N

Ingredient

AMPHOTERICIN B 50MG

Hsn Code

30049029

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