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About tibolone
Tibolone works by mimicking the activity of the female sex hormones, oestrogen and progesterone. It also has some male hormone (androgen) effects. Tibolone helps to restore the balance of female hormones in women who have a lack of oestrogen; it helps to ease symptoms such as hot flushes and night sweats. You will only be prescribed it if these symptoms seriously interfere with your daily life.
Tibolone is also prescribed to help prevent ‘thinning’ of the bones (osteoporosis). It is only suitable for women who have been through the menopause, and providing there have been at least 12 months since the last natural period. It is prescribed when other, more preferred, treatments are not suitable.
Before taking tibolone
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking tibolone it is important that your doctor or pharmacist knows:
If you (or a close family member) have had breast cancer.
If you have had a cancer that you have been told is hormone-dependent
If you have any unexplained vaginal bleeding.
If you have liver disease, or if you have any problems with the way your kidneys work.
If you know you have high levels of fat (triglycerides or cholesterol) in your blood.
If you have ever had a blood clot in your leg or lungs, or if you have had inflammation of a vein (thrombophlebitis).
If you have angina, or if you have had a heart attack or stroke.
If there is a possibility you might be pregnant.
If you have diabetes mellitus.
If you have migraines, or migraine-like headaches
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine.
How to take tibolone
Before you start taking the tablets, read the manufacturer’s printed information leaflet from inside your pack. The manufacturer’s leaflet will give you more information about tibolone and a full list of the side-effects which you may experience from taking it.
Take one 2.5 mg tablet every day. You may take tibolone at whatever time of day you find easiest to remember, but try to take your doses at the same time of day, each day. You can take the tablets before or after meals. You may find it helps to swallow the tablet with a drink of water.
If you forget to take a dose, take it as soon as you remember unless you are more than 12 hours late. If you are more than 12 hours late, leave out the forgotten dose and take your next tablet at the usual time. Do not take two tablets together to make up for a missed dose.
Side Effects
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with tibolone. You will find a full list in the manufacturer’s information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common tibolone side-effects (these affect fewer than 1 in 10 women)
What can I do if I experience this?
Pain in the lower abdomen, increased weight, unusual hair growth, breast tenderness
If any of these become troublesome, speak with your doctor
Vaginal thrush (redness and itching in the vagina)
Speak with your doctor or pharmacist for advice
Vaginal bleeding and spotting
This may happen when you first start tibolone and is nothing to worry about. If it continues for more than a few months, you should let your doctor know about it
If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist.
How to store tibolone
Keep all medicines out of the sight and reach of children.
Store in a cool, dry place, away from direct heat and light.
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