They are several benefits of catfish, some of which includes a great source of anti-inflammatory omega 3s, and a great source of protein.? Catfish also packs a punch for essential nutrients our bodies needs to function.? The extremely high levels of vitamin B-12 in catfish supports normal red blood cell formation and neurological health as well as a myriad of other health benefits. Minerals present in catfish helps to carry ous vital bodily functions geared toward keeping your bones, muscles, heart and brain working properly.