INTRODUCTION
CITICOP P TABLET is a combination of Citicoline and Piracetam which belongs to the group of medicines called Cerebroactive drugs. It is used as an adjunct for the treatment of acute stroke.
Acute stroke can be defined as a brain injury caused due to sudden loss in blood flow, nutrients and oxygen supply to the brain. It is usually characterized by paralysis of one side of the body, loss of sensation, double vision, difficulty in sleeping, facial droop, loss of balance, vertigo, nausea, vomiting, headache and/or blurred vision.
CITICOP P TABLET can also be used to treat memory problems caused due to brain injury and other age-related brain problems.
Before taking CITICOP P TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any bleeding problems, history of bleeding in the brain or parkinsonism.
CITICOP P TABLET is not recommended for use in patients with Huntington Disease, intracranial hemorrhage (bleeding within the skull) or a previous history of depression. It is also not suitable for use in pregnant or breastfeeding women unless considered necessary by the physician.
Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with CITICOP P TABLET.
The most common side effects of taking CITICOP P TABLET are headache, constipation, diarrhea, difficulty in falling asleep, nervousness, dizziness and weight gain. Consult your doctor if any of these side effects bother you.
USES OF CITICOP P TABLET
It is used to treat:
Acute stroke

Memory loss associated with aging or brain injury

HOW CITICOP P TABLET WORKS
CITICOP P TABLET contains two medicines namely citicoline and piracetam. Citicoline is a neuroprotectant. It protects the nerve cells by blocking the release of certain chemicals (such as glutamate and other free radicals) within the brain and nervous system that damages the nerve cells.
Piracetam is a GABA analogue. It improves oxygen supply to the brain and nervous system and protects it from further injury. Collectively, CITICOP P TABLET repairs the brain cells and regulates proper nerve signal transmissions across the brain and the nervous system.
DIRECTIONS FOR USE
Take CITICOP P TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking CITICOP P TABLET unless your doctor advice you to stop.
SIDE EFFECTS OF CITICOP P TABLET

COMMON

Weight gain

Headache

Feeling nervous

Muscle spasms

Anxiety or agitation

Numbness, tingling sensation

Constipation, diarrhea, stomach upset

Dizziness

Difficulty in falling asleep

Nausea, vomiting

Skin rash

Back pain, shoulder pain, joint pain

UNCOMMON

Feeling sad or depressed

Tiredness, weakness

RARE
Stop taking CITICOP P TABLET and contact your doctor immediately if you experience any of the following side effects:
Severe allergic reaction (such as skin rash, swelling of the face, eyelids, lips, tongue or throat which causes difficulty in breathing or swallowing)

HOW TO MANAGE SIDE EFFECTS
Nausea:
Take CITICOP P TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache: ?
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
WARNING & PRECAUTIONS

PREGNANCY
CITICOP P TABLET should be used in pregnancy only if it is considered necessary by the physician. Your doctor will evaluate the risks and benefits of the therapy and prescribes it to you accordingly. Therefore, inform your doctor before taking CITICOP P TABLET if you are pregnant, think you may be pregnant or planning to have a baby. Women of childbearing age must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with CITICOP P TABLET.
BREASTFEEDING
CITICOP P TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you experience drowsiness or shakiness after taking CITICOP P TABLET.
ALCOHOL
Consumption of alcohol is not recommended during treatment with CITICOP P TABLET.
KIDNEY
CITICOP P TABLET is not recommended for use in patients who have or ever had any severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
LIVER
CITICOP P TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
ALLERGY
Do not take CITICOP P TABLET if you are allergic to Citicoline or Piracetam.
OTHERS
CITICOP P TABLET is not recommended for use if you:
Have a previous history of bleeding in the brain

Have Huntington Disease (a rare genetic disease that causes degeneration of nerve cells)

Have prolonged bleeding within the skull (intracranial hemorrhage)

Have trimethylaminuria (fishy odor in the urine)

Have Parkinson?s disease

Have a previous history of depression
Before taking CITICOP P TABLET inform your doctor if you:
Have any bleeding problems
Use in Pediatrics:
CITICOP P TABLET should be used in children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor for advice.
Use in Geriatrics:
CITICOP P TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug Interactions
Before taking CITICOP P TABLET inform to your doctor if you are taking any of the following medicines such as:
Medicines used to treat thyroid problems (Ex. thyroxine, thyroid extract)

Medicines used for blood thinning (Ex. warfarin)

Aspirin (a medicine used for pain relief)

Levodopa (a medicine used for parkinsonism)

Meclofenoxate (a dietary supplement used to improve memory)
Overdosage:
If you or anyone else accidentally took more CITICOP P TABLET, consult your doctor immediately or visit the nearby hospital straight away. Symptoms of overdosage might include severe headache or severe stomach pain with bloody diarrhea.
SYNOPSIS

Drug :?? Citicoline, Piracetam

Pharmacological Category :?? Pyrimidine Ribonucleoside diphosphates, GABA analogs

Therapeutic Indication :?? Stroke

Dosage Forms :?? Tablet, Capsule, Syrup

MORE INFORMATION

Keep CITICOP P TABLET out of reach of children

Store CITICOP P TABLET at room temperature

FAQs ABOUT CITICOP P TABLET
What are the uses of CITICOP P TABLET?
CITICOP P TABLET is used as an adjunct for the treatment of acute stroke.
How CITICOP P TABLET works?
CITICOP P TABLET improves blood flow and oxygen supply to the brain and nervous system and protects it from further injury. It also repairs the brain cells and regulates proper nerve signal transmissions across the brain and the nervous system.
What is the best time to take CITICOP P TABLET?
Take CITICOP P TABLET as advised by your physician. Your doctor will decide the best time for you to take CITICOP P TABLET. Therefore, consult your doctor for advice.
What are the side effects of taking CITICOP P TABLET?
The most common side effects of taking CITICOP P TABLET are headache, constipation, diarrhea, difficulty in falling asleep, nervousness, dizziness and weight gain. Consult your doctor if any of these side effects bother you.
Can I consume alcohol along with CITICOP P TABLET?
It is advisable to avoid alcohol consumption while taking CITICOP P TABLET to achieve maximum benefits.
Who should not take CITICOP P TABLET?
CITICOP P TABLET is not recommended for use in patients with severe liver or kidney problems. It is also not suitable for use in patients with Huntington Disease, parkinsonism, prolonged bleeding within the skull (intracranial hemorrhage), trimethylaminuria (fishy odor in the urine) or a previous history of cerebral bleeding or depression. Do not take CITICOP P TABLET if you are pregnant or breastfeeding without consulting your doctor.
What should I do if I forget to take a dose of CITICOP P TABLET?
If you forget to take a dose of CITICOP P TABLET, take it as soon as you remember. However, if it is time to take the next dose of CITICOP P TABLET, skip the missed dose and take the next one at regular times. Do not take a double dose of CITICOP P TABLET to compensate the missed dose, as it could lead to toxicity.
Can I stop taking CITICOP P TABLET once my symptom subsides?
Do not stop taking CITICOP P TABLET unless your doctor advice you to stop, as sudden withdrawal of the therapy may cause unpleasant withdrawal symptoms such as muscle twitching or jerky movements. If you feel better after using CITICOP P TABLET, consult your doctor for advice. Your doctor will gradually reduce the dose before complete cessation of the therapy.
Can CITICOP P TABLET be used during pregnancy?
CITICOP P TABLET should be used in pregnancy only if it is considered necessary by the physician. Your doctor will evaluate the risks and benefits of the therapy and prescribes it to you accordingly.
How to take CITICOP P TABLET?
You must take CITICOP P TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
REFERENCES
1. KD. Tripathi. CNS stimulants and cognition enhancers. Essentials of Medical Pharmacology. Seventh Edition. May 2013. Page ? 490 & 491.
2. Jos? ?lvarez-Sab?n and Gustavo C. Rom?n. The Role of Citicoline in Neuroprotection and Neurorepair in Ischemic Stroke. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. September 2013. [Accessed on 17th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061873/
3. P.P. De Deyn, J D Reuck, W Deberdt, R Vlietinck, J M Orgogozo. Treatment of acute ischemic stroke with piracetam. Members of the Piracetam in Acute Stroke Study (PASS) Group. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 1997. [Accessed on 17th October 2022] https://pubmed.ncbi.nlm.nih.gov/9412612/
4. Cipla Ltd. Cognolin P Tablet. [Revised in September 2020] [Accessed on 17th October 2022]. https://www.ciplamed.com/content/cognolin-p-tablets
5. Torrent Pharmaceuticals Ltd. Strolin-P (Citicoline+Piracetam Tablets). [Accessed on 17th October 2022]. https://www.torrentian.com/pisheet/Upload/PI_Sheet/2267.pdf
6. Leeford Healthcare Ltd. Nurocot P. Citicoline+Piracetam Tablets. [Accessed on 19th October 2022] https://www.leeford.in/product/763/nurocot-p
7. BioBrick Pharma. Biocoline-P. Citicoline+Piracetam Tablets. [Accessed on 19th October 2022]. https://www.biobrickpharma.com/product/citicoline-sodium-piracetam-tablets-2/
8. Central Drug Standard Control Organization. Citicholine 500mg + Piracetam 400mg Tablets [Revised in October 2010]. [Accessed on 19th October 2022]. https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
USEFUL DIAGNOSTIC TESTS

Activated Partial Thromboplastin Time

Complete Blood Count

Prothrombin Time

VIDEOS

Citicoline+Piracetam Tablet ? Drug Information
Citicoline+Piracetam Tablet : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
PRODUCT DETAILS

Country Of Origin

India

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