Dacotin 100mg Injection 1?S Allschoolabs -

Description

INTRODUCTION
DACOTIN 100MG INJECTION contains Oxaliplatin which belongs to the group of medicine called Anticancer drugs. It is used to treat cancers of the colon and/or rectum. It is highly used in combination with other anti-cancer medicines (such as 5-flurouracil and folinic acid) as an adjunct to treat stage III colon cancer after removing the primary tumour. It can also be used to treat metastatic colorectal cancer (cancer of colon and rectum that has been spread to other parts of the body).
Before receiving DACOTIN 100MG INJECTION inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have low white blood count in your blood or recently received or planning to receive any vaccination in the upcoming days.
DACOTIN 100MG INJECTION is not recommended for use in pregnant or breastfeeding women and in children aged below 18 years. Men and women receiving DACOTIN 100MG INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with DACOTIN 100MG INJECTION.
The most common side effects of receiving DACOTIN 100MG INJECTION are tingling and numbness of body parts, abnormal sensation in the throat, nausea, vomiting, stomach pain, headache, dizziness, tiredness, weight loss, changes in taste, skin rash, hair loss, mouth ulcers and low blood calcium levels. Contact your doctor if any of these side effect worsens.
USES OF DACOTIN 100MG INJECTION
It is used to treat:
Colon cancer (stage III)

Metastatic colorectal cancer

HOW DACOTIN 100MG INJECTION WORKS
DACOTIN 100MG INJECTION is an anticancer medication. It works by damaging the DNA (genetic material) of the cancer cells. As a result, it reduces abnormal growth and multiplication of cancer cells in the body.
DIRECTIONS FOR USE
DACOTIN 100MG INJECTION will be given to you only by a doctor or a nurse into a vein (as an intravenous infusion).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF DACOTIN 100MG INJECTION

COMMON

Nerve pain, tingling and numbness of body parts

Abnormal sensation in the throat, problems in breathing

Diarrhea, nausea, vomiting, constipation, stomach pain

Indigestion, heartburn, hiccups

Low blood counts (causing bleeding, anemia and increased infections)

Injections site reactions (pain and discomfort)

Fever, shakiness, headache, dizziness, tiredness, body pains

Weight loss, lack of appetite

Changes in taste, nasal bleeds

Skin rash, itching, flaky skin, hair loss, flushing

Nail disorder, increased sweating

Joint pain

Passing little or no urine

High blood pressure

Depression and lack of sleep

Low blood calcium levels

Neck stiffness

UNCOMMON

Nervousness

RARE

Loss of hearing
Contact your doctor immediately if you experience any of the following side effects after receiving DACOTIN 100MG INJECTION:
Signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth?or throat which can lead to difficulty in breathing or swallowing)

Mouth ulcers (oral sores)

Low platelet count in blood causing excessive unusual bruising

Dry cough, difficulty in breathing and crackling sounds

Sepsis (blood infections)

Low WBC count causing fever or flu-like symptoms

Signs of blood clots in lungs (chest pain, difficulty in breathing, coughing up blood)

Blockage or swelling in the intestines

Problems in hearing, ringing sound in the ears and spinning sensation

Severe persistent diarrhea and vomiting

Short-term vision loss

Signs of reversible posterior leukoencephalopathy syndrome (a nerve disorder causing headache, altered mental functioning, seizures and abnormal vision from blurriness to vision loss)

Signs of Haemolytic-uraemic syndrome (such as extreme tiredness, low RBC count, shortness of breath, low platelet count, abnormal bruising, passing little or no urine)

Inflammation of the lungs

Pain in upper abdomen and back with nausea and vomiting

Vascular disorders of the liver (symptoms include abdominal pain and swelling, weight gain and tissue swelling of the feet, ankles or other parts of the body)

Bleeding in the gut causing bloody stools or vomits

HOW TO MANAGE SIDE EFFECTS
Skin rash:
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Nausea and Vomiting:
Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea worsens, consult your doctor for advice.
Mouth ulcers:
Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.
Diarrhoea:
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.
Constipation:
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals?and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.
WARNING & PRECAUTIONS

PREGNANCY
DACOTIN 100MG INJECTION is generally not recommended for use in pregnant women. However, consult your doctor before receiving it. Women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with DACOTIN 100MG INJECTION and until 4 months after stopping the therapy. If you accidentally became pregnant while receiving DACOTIN 100MG INJECTION, inform your doctor immediately.
BREASTFEEDING
DACOTIN 100MG INJECTION is not recommended for use in women who are breastfeeding. Therefore, consult your doctor before receiving it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if your ability is affected by DACOTIN 100MG INJECTION.
KIDNEY
DACOTIN 100MG INJECTION is not recommended to use in patients with severe kidney problems. It should be used with caution in patients with mild to moderate kidney problems. Therefore, consult your doctor before receiving it.
LIVER
DACOTIN 100MG INJECTION should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.
ALLERGY
Talk to your doctor before receiving DACOTIN 100MG INJECTION if you are allergic to Oxaliplatin or to any other platinum-based anticancer medicines (such as carboplatin, cisplatin).
HEART DISEASE
DACOTIN 100MG INJECTION should be used with caution in patients with heart problems (such as prolongation of the QT interval, an irregular heartbeat). It should also be used with caution in patients having a family history of heart problems. Therefore, consult your doctor before receiving it.
OTHERS
DACOTIN 100MG INJECTION is not recommended for use if you have:
Reduced number of blood cells

Tingling and numbness in the fingers and/or toes

Difficulty in performing delicate tasks (such as buttoning clothes)
Inform your doctor, before receiving DACOTIN 100MG INJECTION, if you:
Recently received any vaccine or plan to receive any vaccines
Use in pediatrics:
DACOTIN 100MG INJECTION is generally not recommended for use in children and adolescents (under 18 years of age). Therefore, consult your doctor before receiving it.
Use in geriatrics:
DACOTIN 100MG INJECTION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.
INTERACTIONS
Drug-Drug interactions:
Inform your physician, before receiving DACOTIN 100MG INJECTION, if you are taking any of the following medicines such as:
Other medicines used to treat cancer (Ex. 5-fluorouracil, paclitaxel)

Medicines used as antibiotics (Ex. erythromycin)

Medicines used to relieve pain (Ex. salicylates)

Medicines used for vomiting (Ex. granisetron)

Medicines used to treat epilepsy (Ex. sodium valproate)

Live or attenuated vaccines (Ex. yellow fever vaccine)
Overdosage:
DACOTIN 100MG INJECTION will be administered to you only by a doctor or a nurse in a hospital?and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms.
SYNOPSIS

Drug :?? Oxaliplatin

Pharmacological Category :?? Platinum-based chemotherapy agent

Therapeutic Indication :?? Colorectal cancer

Dosage Forms :?? Injection, Infusion

MORE INFORMATION

Keep DACOTIN 100MG INJECTION out of reach of children

Store DACOTIN 100MG INJECTION below 25?C

FAQs ABOUT DACOTIN 100MG INJECTION
What DACOTIN 100MG INJECTION is used for?
DACOTIN 100MG INJECTION is used to treat colorectal cancer. It can also be used to treat metastatic colorectal cancer and can be used an adjunct to treat stage III colon cancer after removing the primary tumour.
How DACOTIN 100MG INJECTION works on my body?
DACOTIN 100MG INJECTION is an anti-cancer medicine. It works by damaging the genetic material (DNA) of the cancer cells. As a result, it reduces abnormal growth and multiplication of cancer cells in the body.
Can DACOTIN 100MG INJECTION cure cancer?
The cure rate of cancer depends upon the severity of the disease. However, DACOTIN 100MG INJECTION acts by preventing the abnormal growth and multiplication of cancer cells in the body, which may help in curing cancer completely.
Can the use of DACOTIN 100MG INJECTION cause hair loss?
Hair loss is one of the common side effects of receiving DACOTIN 100MG INJECTION. If it bothers you, consult your doctor for advice.
Can the use of DACOTIN 100MG INJECTION cause mouth ulcers?
Mouth ulcers are one of the common side effects of receiving DACOTIN 100MG INJECTION. Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.
Can DACOTIN 100MG INJECTION be used in children?
DACOTIN 100MG INJECTION should not be used in children aged below 18 years. Therefore, consult your doctor before receiving it.
Is DACOTIN 100MG INJECTION a chemo drug?
Yes. DACOTIN 100MG INJECTION contains a medicine called oxaliplatin which is a platinum-based chemotherapeutic agent. It stops abnormal growth and multiplication of cancer cells in the body.
What precautions must be followed while taking DACOTIN 100MG INJECTION?
Before taking DACOTIN 100MG INJECTION inform your doctor if you have any liver, kidney or heart problems. Inform your doctor before receiving DACOTIN 100MG INJECTION if you are a pregnant or a breastfeeding woman. Men and women receiving DACOTIN 100MG INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with DACOTIN 100MG INJECTION.
What happens if I stop receiving DACOTIN 100MG INJECTION?
No. Do not stop receiving DACOTIN 100MG INJECTION without consulting your doctor as it may make your symptoms reappear. Therefore, take DACOTIN 100MG INJECTION as advised by your doctor for the stipulated duration.
Can DACOTIN 100MG INJECTION be used during pregnancy?
DACOTIN 100MG INJECTION is generally not recommended for use in pregnant women. If you accidentally became pregnant while receiving DACOTIN 100MG INJECTION, inform your doctor immediately.
Can the use of DACOTIN 100MG INJECTION make me feel tired?
Yes. DACOTIN 100MG INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after receiving DACOTIN 100MG INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while taking this medicine.
Can I drive a car after receiving?DACOTIN 100MG INJECTION?
DACOTIN 100MG INJECTION may make you feel tired or dizzy. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by DACOTIN 100MG INJECTION.
How DACOTIN 100MG INJECTION is administered?
DACOTIN 100MG INJECTION will be given to you only by a doctor or a nurse into a vein (as an intravenous infusion).
How to control nausea caused due to DACOTIN 100MG INJECTION?
Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with DACOTIN 100MG INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.
What are the side effects of receiving DACOTIN 100MG INJECTION?
The most common side effects of receiving DACOTIN 100MG INJECTION are tingling and numbness of body parts, abnormal sensation in the throat, nausea, vomiting, stomach pain, headache, dizziness, tiredness, weight loss, changes in taste, skin rash, hair loss, mouth ulcers and low blood calcium levels. Contact your doctor if any of these side effect worsens.
Who should avoid taking DACOTIN 100MG INJECTION?
DACOTIN 100MG INJECTION is not recommended for use if you are allergic to oxaliplatin. It is also not recommended for use in pregnant or breastfeeding women and in children (aged below 18 years).
Is?DACOTIN 100MG INJECTION safe to use in kidney disease?
DACOTIN 100MG INJECTION should be used with caution in patients with kidney problems. Your doctor will access your health condition and suggest a suitable dose for you.
Can the use of DACOTIN 100MG INJECTION affect the liver?
Yes. DACOTIN 100MG INJECTION may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
REFERENCES
1. KD. Tripathi. Anticancer Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page ? 862.
2. Zaoqin Yu, Rui Huang, Li Zhao, Ximin Wang, Xiaofang Shangguan, Wei Li, Min Li, Xianguo Yin, Chengliang Zhang and Dong Liu. Safety Profile of Oxaliplatin in 3,687 Patients With Cancer in China: A Post-Marketing Surveillance Study. Frontiers in Oncology. October 2021 [Accessed on 14th November 2022]?https://www.frontiersin.org/articles/10.3389/fonc.2021.757196/full
3. T. Alcindor, MD and N. Beauger, PhD MBA. Oxaliplatin: a review in the era of molecularly targeted therapy. Journal of Current Oncology. February 2011 [Accessed on 14th November 2022]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031353/
4. E.Raymond, S.G.Chaney, A.Taamma, E.Cvitkovic. Oxaliplatin: A review of preclinical and clinical studies. Journal of Annals of Oncology. October 1998 [Accessed on 9th November 2022]?https://www.sciencedirect.com/science/article/pii/S0923753419482045
5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 14th November 2022]?https://www.medicines.org.uk/emc/files/pil.6088.pdf, https://www.medicines.org.uk/emc/product/6088/smpc
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