INTRODUCTION
DIPRO 75MG TABLET contains Divalproex, which belongs to the group of medicines called Anti-epileptic drugs. It is used to treat manic episodes related to bipolar disorder. It is also used in adults and children (10 years and above) to treat complex partial seizures, with or without other seizure types and to prevent migraine headaches.
Epilepsy (fits or seizures) is a condition that occurs as a result of the abnormal electrical activity of the brain, which may lead to loss of consciousness, abnormal muscle movements or behaviour, etc. Partial seizures involve a specific area of the brain but may spread to the entire brain and cause a generalized tonic-clonic seizure. Before the treatment, your physician may want you to take relevant tests to understand your existing condition. Avoid consumption of alcohol DIPRO 75MG TABLET, as it may make you feel drowsy.
DIPRO 75MG TABLET is not recommended for use in patients with liver disease or significant liver dysfunction or urea cycle disorders. Before taking DIPRO 75MG TABLET, inform your physician if you have kidney problems, systemic lupus erythematosus and porphyria. DIPRO 75MG TABLET should be used with caution by pregnant and breastfeeding women. DIPRO 75MG TABLET is not recommended for use by children (aged 10 years or younger).
The most common side effects of taking DIPRO 75MG TABLET are nausea, vomiting, dizziness, double vision, weight gain, problems with walking or coordination, headache, weakness, stomach pain, diarrhoea, hair loss, sleepiness, tremors, blurry vision, increased appetite, loss of appetite, etc. Contact your physician if any of the side effects worsen or if you have thoughts of harming yourself.
USES OF DIPRO 75MG TABLET

Treats mania and bipolar disorder

Treats complex partial seizures, with or without other seizure types

Treats migraine

HOW DIPRO 75MG TABLET WORKS
DIPRO 75MG TABLET helps to control abnormal electrical activity in the brain (by binding to sodium channels), thus reducing the chances of having fits or seizures.
DIRECTIONS FOR USE
Take DIPRO 75MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF DIPRO 75MG TABLET

COMMON

Nausea

Vomiting

Dizziness

Double vision

Weight gain

Problems with walking or coordination

Headache

Weakness

Stomach pain

Diarrhoea

Hair loss

Sleepiness

Tremor

Blurry vision

Increased appetite

Loss of appetite

RARE

Fanconi?s syndrome mostly in children
Stop taking DIPRO 75MG TABLET and contact your physician immediately if you experience any of the following side effects:
Bleeding problems (Ex. red or purple spots on the skin, bruising, pain and swelling in the joints due to bleeding or bleeding from the mouth or nose)

High ammonia levels in the blood (signs include feeling tired, vomiting and changes in mental status)

Low body temperature (hypothermia) (drop in the body temperature to less than 95? F, feeling tired, confusion, coma)

Allergic (hypersensitivity) reactions (symptoms include fever, skin rash, hives, sores in the mouth, blistering and peeling of the skin, swelling of the lymph nodes, swelling of the eyes, face, lips, tongue, or throat, trouble swallowing or breathing)

Drowsiness or sleepiness in the elderly

Nausea or vomiting that does not go away, loss of appetite, pain on the right side of the stomach (abdomen), dark urine, swelling of the face or yellowing of the skin or the whites of the eyes

Inflammation of the pancreas (signs include stomach pain, pain in the back, nausea or vomiting that does not go away)

Thoughts of harming or killing yourself

HOW TO MANAGE SIDE EFFECTS
Nausea:
Take DIPRO 75MG TABLET with or immediately after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your symptom gets worse or persist.
Vomiting:
Take adequate rest and drink sufficient amount of water. Do not take spicy or oily foods. Consult your doctor if your symptom gets worse or persist.
Headache:
Drink an ample amount of water. Get adequate rest. Try to be relaxed and stress-free. Ask your physician before taking any medicine for headaches. Consult your doctor if your symptom gets worse or persist.
Dizziness:
Lie down till the dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. Consult your doctor if your symptom gets worse or persist.
Diarrhoea:
Drink more fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your physician. Consult your doctor if your symptom gets worse or persist.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heating pad on your stomach. If the symptom does not improve, contact your physician. Consult your doctor if your symptom gets worse or persist.
Loss of appetite:
Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you?re hungry. Eat a nutritious snack that is rich in calories and protein, such as dried fruit and nuts. Consult your doctor if your symptom gets worse or persist.
WARNING & PRECAUTIONS

PREGNANCY
DIPRO 75MG TABLET should be used with caution in pregnant women as it can cause developmental defects and decreased IQ level of the baby. Consult your physician before taking it.
BREASTFEEDING
DIPRO 75MG TABLET should be used with caution in breastfeeding women only if recommended by your doctor, as it passes through the breast milk and can affect breastfeeding babies. Consult your physician before taking DIPRO 75MG TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines after taking DIPRO 75MG TABLET if you experience dizziness, drowsiness, balance or coordination problems, eye problems like double or blurred vision, low blood levels of sodium causing muscle weakness, or decreased consciousness.
ALCOHOL
Avoid consumption of alcohol while taking DIPRO 75MG TABLET as it might make you feel sleepy or drowsy. Consult your physician for advice.
ALLERGY
Do not take DIPRO 75MG TABLET if you are allergic to Divalproex or any of the other ingredients of this medicine.
OTHERS
Do not take DIPRO 75MG TABLET, if you have:
POLG and its associated disorder, especially in children less than 2 years of age

Urea cycle disorders
Before taking DIPRO 75MG TABLET, inform your physician if you have:
Systemic lupus erythematosus

Porphyria

Bleeding or other disorders of the blood

Pancreatitis

Hyperammonemia and hyperammonemic encephalopathy

DRESS syndrome
Use in pediatrics:
DIPRO 75MG TABLET is not recommended for use in children (under 10 years of age) as it has not been shown to be safe and effective in this age group. It should be used with caution in children (10 years and older). Consult your physician before taking DIPRO 75MG TABLET.
Use in geriatrics:
DIPRO 75MG TABLET should be used with caution in elderly patients (aged above 65 years) with kidney impairment. Consult your physician before taking DIPRO 75MG TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking DIPRO 75MG TABLET, inform your physician if you are taking any of the following medicine:
Other medicines used to treat fits (Ex. phenobarbital, phenytoin, carbamazepine, lamotrigine, valproic acid, felbamate and topiramate)

Medicines used to prevent pregnancy (Ex. ethinyl estradiol, desogestrel)

Medicines to treat mental illness (Ex. lithium, phenelzine, moclobemide)

Medicines used to relieve pain and inflammation (Ex. indomethacin, ibuprofen, acetaminophen)

Medicines used to control your immune system (Ex. ciclosporin, tacrolimus)

Rifampicin, meropenem (used to treat infections)

Antacids (Ex. aluminium hydroxide, magnesium carbonate)

Medicines used to treat ulcers (Ex. cimetidine and ranitidine)

Medicines used to thin the blood (Ex. warfarin, aspirin)

Medicines used to treat HIV (Ex. zidovudine)
Overdosage:
If you or anyone else accidentally take too much of DIPRO 75MG TABLET, consult your physician immediately or visit the nearby hospital. Symptoms of overdose are drowsiness, heart block and deep coma.
SYNOPSIS

Drug :?? Divalproex

Pharmacological Category :?? Antiepileptics

Therapeutic Indication :??
Mania, bipolar disorder, seizure disorder, migraine
Dosage Forms :??
Tablet, Capsule, Oral Solution, Solution
MORE INFORMATION

Keep DIPRO 75MG TABLET out of reach of children

Store DIPRO 75MG TABLET at room temperature

FAQs ABOUT DIPRO 75MG TABLET
Can taking DIPRO 75MG TABLET lead to suicidal thoughts?
Thoughts of harming or killing self are seen in a small number of patients being treated with DIPRO 75MG TABLET. If you have such thoughts at any time, immediately contact your physician or go to the nearby hospital.
Can I continue taking my contraceptive pill with DIPRO 75MG TABLET?
No. DIPRO 75MG TABLET can stop hormonal contraceptives from working properly. Another form of contraception should also be used to help prevent unwanted pregnancy while taking DIPRO 75MG TABLET. Inform your physician immediately if you have irregular vaginal bleeding or spotting. If you have any doubts about this, discuss it with your physician.
Can I crush DIPRO 75MG TABLET if I cannot swallow it whole?
No. Swallow DIPRO 75MG TABLET with a glass of water. If you cannot swallow it whole, do not crush or chew it. Instead, break the medicine with the help of the score line. Consult your, physician, for other forms of DIPRO 75MG TABLET that you can take.
What if I forget to take a dose of DIPRO 75MG TABLET?
If you forget to take a dose of DIPRO 75MG TABLET, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take DIPRO 75MG TABLET twice to make up for a forgotten dose.
Can I stop taking DIPRO 75MG TABLET?
Do not stop taking DIPRO 75MG TABLET without consulting your physician, as it can lead to a sudden increase in fits. If you have any more doubts about using DIPRO 75MG TABLET, ask your physician.
Can DIPRO 75MG TABLET be used in pregnancy?
DIPRO 75MG TABLET should be used with caution in pregnancy as there may be a risk to your baby. However, it is important to control epileptic fits during pregnancy. Your physician will help you decide whether you should take DIPRO 75MG TABLET by discussing the benefits and risks involved. Do not stop your treatment with DIPRO 75MG TABLET during pregnancy without asking your physician.
REFERENCES
1. KD Tripathi. Antiepileptic Drugs. Essentials of medical pharmacology. Eighth Edition. 2019. Page 411? 424.
2. Steven C Stoner and Megan M Dahmen. Extended-release divalproex in bipolar and other psychiatric disorders: A comprehensive review. Journal of Neuropsychiatric Disease and Treatment. December 2007. [Accessed on 21st July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656326/
3. Nilesh Shah, M.S.Reddy, Sandeep Vohra, Uday Chaudhuri, Senthilnathan Mohanasundaram. Safety and effectiveness of divalproex sodium extended release containing regimen in Indian patients with bipolar I disorder in continuation phase: Results of EASED registry. Asian Journal of Psychiatry. April 2016. [Accessed on 21st July 2022] https://www.sciencedirect.com/science/article/abs/pii/S1876201815002816
4. Epilepsy Foundation. Divalproex Sodium. [Accessed on 21st July 2022] https://www.epilepsy.com/tools-resources/seizure-medication-list/divalproex-sodium
5. AbbVie Inc. U.S. Food and Drug Administration. [Revised in February 2016] [Accessed on 21st July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018723s056lbl.pdf
6. Abbott Laboratories. Food and Drug Administration. [Revised in February 2016] [Accessed on 21st July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/18081s44,18082s27,18723s33,19680s22,20593s15,21168s14lbl.pdf
7. AbbVie Inc. Depakote. [Revised in February 2016] [Accessed on 21st July 2022] https://www.depakote.com/
USEFUL DIAGNOSTIC TESTS

Electroencephalogram (EEG)

MRI

VIDEOS

Divalproex Tablet ? Drug Information
Divalproex Tablet : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
Net Qty

1 N

Ingredient

DIVALPROEX 75 MG

Hsn Code

30049099

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