Docetere 80mg Injection 1?s Allschoolabs -

Description

INTRODUCTION
DOCETERE 80MG INJECTION contains Docetaxel which belongs to the group of medicines called Taxoids. DOCETERE 80MG INJECTION is used in the treatment of breast cancer, special forms of lung cancer (non-small cell lung cancer), prostate cancer, gastric (stomach) cancer?and/or head and neck cancer in affected individuals.
DOCETERE 80MG INJECTION is not recommended for use in patients allergic to docetaxel. It is not recommended for use in patients with low number of white blood cells and in patients suffering from severe liver disease.
Before receiving DOCETERE 80MG INJECTION, inform your doctor if you are alcohol dependent and/or suffering from epilepsy, heart and/or kidney diseases.
DOCETERE 80MG INJECTION is not recommended for use during pregnancy unless it is clearly necessary. Women of child-bearing potential should use effective contraception method to avoid getting pregnant while receiving DOCETERE 80MG INJECTION. The medicine is also not recommended for use in breastfeeding women.
DOCETERE 80MG INJECTION should be used with caution in children and adolescents (aged below 18 years) which is also advised to be used to with caution in elderly patients (aged above 65 years) after consulting the doctor.
The most common side effects of receiving DOCETERE 80MG INJECTION are infection, hair loss, headache, loss of appetite, indigestion, nausea, vomiting and/or constipation. Consult your doctor if any of these symptoms worsen.
USES OF DOCETERE 80MG INJECTION

Treats breast cancer and special forms of lung cancer (non-small cell lung cancer)

Treats prostate cancer, gastric cancer and head & neck cancer in affected individuals

HOW DOCETERE 80MG INJECTION WORKS
DOCETERE 80MG INJECTION works by interfering with the microtubule structures in the cell (substance which aids cancer cells to divide and multiply) thus inhibiting the growth of cancer cells and preventing its spread in affected individuals.
DIRECTIONS FOR USE
DOCETERE 80MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF DOCETERE 80MG INJECTION

COMMON

Infections, decrease in red and white blood cells count, low platelet count

Hair loss

Headache, loss of appetite, indigestion, nausea, vomiting, constipation, diarrhoea

Sores in the mouth, dry mouth, difficulty/painful swallowing

Sleeplessness, tiredness, dizziness, dehydration

Signs of allergic reactions such as flushing, skin reactions, itching, chest tightness, difficulty in breathing, fever/chills, back pain, low blood pressure

Tingling/prickling sensation in joints/muscles, redness and swelling of palms of hands / soles of feet, change in the colour of your nails

Alteration in sense of taste

Inflammation of throat and nose, bleeding from nose, inflammation of eye/increased tearing of the eyes, breath muscle aches and pains, back pain/bone pain

Nasal drainage, swelling due to lymphatic drainage

Shortness of breath, low blood pressure

Change/absence of menstrual period

Flu-like symptoms

Weight gain/loss

Infection of the upper respiratory tract

Oral candidiasis

Hearing impaired, inflammation of oesophagus

Irregular/rapid heartbeat.

UNCOMMON

Skin reactions at injection site

Fainting, phlebitis (inflammation of the vein)/swelling

Blood clots

Blood cancer (may occur when used with other anticancer treatments).

RARE

Inflammation of colon/intestine, intestinal perforation.
Stop receiving DOCETERE 80MG INJECTION and contact doctor immediately if you experience any of the following
Signs of severe allergic reaction such as flushing, skin reactions, itching, chest tightness, difficulty in breathing, fever/chills, back pain, low blood pressure

Fever

Signs of serious gastrointestinal toxicity such as abdominal pain/tenderness, diarrhoea, rectal haemorrhage, blood in stool and/or fever

Vision problems especially blurred vision

Signs of acute or worsening lung problems such as fever, shortness of breath and/or cough

Skin reactions such as Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis (associated with signs such as blistering, peeling/bleeding on any part of skin with/without a rash) and Acute Generalized Exanthematous Pustulosis (associated with signs such as red, scaly widespread rash with bumps under the swollen skin accompanied with fever)

Signs of ventricular arrhythmia/ tachycardia (condition marked by irregular heart rhythms) such as irregular/rapid heartbeat, severe shortness of breath, dizziness and/or fainting

Signs of Tumour lysis syndrome (serious condition marked by massive death of cancer cells) such as seizures, kidney failure and/or heart rhythm disturbance.

HOW TO MANAGE SIDE EFFECTS
Headache:
If DOCETERE 80MG INJECTION causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving DOCETERE 80MG INJECTION. If it lasts more than a week or severe, inform your doctor.
Indigestion:
Try to have smaller and more frequent meals and drink slowly. Reduce consumption of coffee, cola, tea or alcohol and lose weight if you are obese.? Try to avoid smoking and don?t have rich, fatty or spicy foods. Consult your doctor and inform if the symptom does not improve.
Nausea and vomiting:
Receive DOCETERE 80MG INJECTION with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if symptom gets worse.
Constipation:
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate treatments for constipation.
Diarrhea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult your doctor and inform them if the symptom gets worse.
Dry mouth:
Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and use mouthwash. Consult and inform your doctor if the symptom gets worse.
Tiredness:
Make sure you take rest and drink plenty of fluids. Avoid or limit the consumption of alcohol. Try to receive DOCETERE 80MG INJECTION at a time when you can sit down (or lie down) when the symptoms are at their worst. Avoid driving or using tools or machinery until you feel well.
Dizziness:
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
WARNING & PRECAUTIONS

PREGNANCY
DOCETERE 80MG INJECTION is not recommended for use during pregnancy unless it is clearly necessary. Women of child-bearing potential should use effective contraception method while receiving DOCETERE 80MG INJECTION. Consult your doctor before receiving the medicine.
BREASTFEEDING
DOCETERE 80MG INJECTION is not recommended for use in breastfeeding women. Consult your doctor before receiving DOCETERE 80MG INJECTION.
DRIVING AND USING MACHINES
Do not drive and operate machines if DOCETERE 80MG INJECTION affects your ability to drive or operate any machines.
ALCOHOL
Avoid consumption of alcohol while receiving DOCETERE 80MG INJECTION since it may cause harmful effects to the patient.
KIDNEY
DOCETERE 80MG INJECTION should be used with caution in patients with kidney disease. Consult your doctor before receiving DOCETERE 80MG INJECTION.
LIVER
DOCETERE 80MG INJECTION is not recommended for use in patients with serious liver disease.? It should be used with caution in patients with other liver diseases. Consult doctor before receiving the medicine.
ALLERGY
Do not receive DOCETERE 80MG INJECTION if you are allergic to Docetaxel and/or any other ingredients in this medicine.
HEART DISEASE
DOCETERE 80MG INJECTION should be received with caution in patients with heart diseases. Consult your doctor before receiving DOCETERE 80MG INJECTION.
OTHERS
DOCETERE 80MG INJECTION is not recommended for use if you:
Have too low number of white blood cells.
Before receiving DOCETERE 80MG INJECTION, inform your doctor if you:
Are alcohol dependent

Are suffering from epilepsy
Use in Pediatrics:
DOCETERE 80MG INJECTION should be used with caution in children and adolescents (aged below 18 years). Consult your doctor before receiving the medicine.
Use in Geriatrics:
DOCETERE 80MG INJECTION should be used with caution in elderly patients (aged above 65 years). Consult your doctor before receiving the medicine.
INTERACTIONS
A. Drug ? Drug interactions
?Before receiving DOCETERE 80MG INJECTION inform your doctor if you are taking the following medicines
Ketoconazole, itraconazole (medicine used to treat fungal infection)

Ritonavir (medicine used to treat viral infections)

Cisplatin, cyclosporine (medicine used to treat cancer)

Doxorubicin (medicine used to treat cancer)

Erythromycin, troleandomycin (medicine used to treat bacterial infection)

Terfenadine (medicine used to treat allergy)

Dalfopristin, quinupristin (medicine used to treat infection of skin and blood)

Vaccine for BCG, measles, mumps, poliovirus, rotavirus, rubella, smallpox, typhoid, varicella, yellow Fever

Thalidomide (medicine used to treat skin cancer).
Overdosage:
DOCETERE 80MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
SYNOPSIS

Drug :?? Docetaxel

Pharmacological Category :?? Taxoid anti-neoplastic agent

Therapeutic Indication :?? Breast cancer, Gastric cancer, Prostate cancer, Non-small cell lung cancer, Head and neck cancer

Dosage Forms :?? Injection

MORE INFORMATION

Keep DOCETERE 80MG INJECTION out of reach of children

Do not store DOCETERE 80MG INJECTION above 25?C

FAQs ABOUT DOCETERE 80MG INJECTION
What is DOCETERE 80MG INJECTION used for?
DOCETERE 80MG INJECTION is used in the treatment of breast cancer, special forms of lung cancer (non-small cell lung cancer), prostate cancer, gastric (stomach) cancer and/or head and neck cancer in affected individuals.
How DOCETERE 80MG INJECTION works?
DOCETERE 80MG INJECTION works by interfering with the microtubule structures in the cell (substance which aids cancer cells to divide and multiply) thus inhibiting the growth of cancer cells and preventing its spread in affected individuals.
What are the most common side effects of receiving DOCETERE 80MG INJECTION?
The most common side effects of receiving DOCETERE 80MG INJECTION are infection, hair loss, headache, loss of appetite, indigestion, nausea, vomiting and/or constipation. Consult your doctor if any of these symptoms worsen.
How to administer DOCETERE 80MG INJECTION?
DOCETERE 80MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Can DOCETERE 80MG INJECTION be used in pregnant and breastfeeding women?
No, DOCETERE 80MG INJECTION is not recommended for use during pregnancy unless it is clearly necessary. Women of child-bearing potential should use effective contraception method while receiving DOCETERE 80MG INJECTION. It is also not recommended for use in breastfeeding women. Consult your doctor before receiving the medicine.
REFERENCES
1. KD. Tripathi. Anticancer drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page ?866.
2. Nicole G. Farha;?Anup Kasi. Docetaxel. NIH National Library of Medicine. National center for Biotechnology information. StarPearls [Internet]. [Revised in February 2022] [Accessed on 26th October 2022]?https://www.ncbi.nlm.nih.gov/books/NBK537242/
3. Ted Zwerdling?,?Mark Krailo,?Philip Monteleone,?Rebecca Byrd,?Judith Sato,?Rose Dunaway,?Nita Seibel,?Zhengjia Chen,?John Strain,?Gregory Reaman,?Children?s Oncology Group. Phase II investigation of docetaxel in pediatric patients with recurrent solid tumors: a report from the Children?s Oncology Group. NIH National Library of Medicine. National center for Biotechnology information. PubMed.gov. [Revised in April 2006] [Accessed on 26th October 2022]?https://pubmed.ncbi.nlm.nih.gov/16532433
4.?Manuel Caitano Maia, Allan A Lima Pereira, Liana Valente Lage, Natalia Moreno Fraile, Victor Van Vaisberg, Guilherme Kudo, Romualdo Barroso-Sousa, Diogo Assed Bastos, Carlos Dzik. Efficacy and Safety of Docetaxel in Elderly Patients With Metastatic Castration-Resistant Prostate Cancer. NIH National Library of Medicine. National center for Biotechnology information. PubMed.gov. [Revised in September 2018] [Accessed on 26th October 2022]?https://pubmed.ncbi.nlm.nih.gov/30241182/
5. Accord Healthcare Limited. Electronic Medicines Compodium (EMC) [Revised in May 2021] [Accessed on 26th October 2022]?https://www.medicines.org.uk/emc/files/pil.11401.pdf
6. Getwell Oncology. Taxewell. [Accessed on 26th October 2022]?https://www.getwelloncology.com/docetaxel-injection-concentrate
USEFUL DIAGNOSTIC TESTS