INTRODUCTION
DONZHEIMER 5 TABLET contains Donepezil which belongs to the group of medicines called Cholinesterase inhibitors. DONZHEIMER 5 TABLET is indicated for the treatment of mild to moderately severe Alzheimer?s dementia.
Alzheimer?s disease is a brain disorder that causes dementia (a group of symptoms that affect the memory, thinking and social abilities of a person) by destroying the memory and other important mental functions in the brain which is characterized by memory loss, confusion, and behavioral changes.
Before taking DONZHEIMER 5 TABLET, inform your doctor if you are allergic to Donepezil, have asthma, heart, kidney, or liver disease.
DONZHEIMER 5 TABLET is not recommended for use if you have severe liver disease. Consult your doctor before taking medicine.
DONZHEIMER 5 TABLET is generally not recommended for use in pregnant and breastfeeding women unless it is considered clearly necessary. Consult your doctor before taking DONZHEIMER 5 TABLET.
The safety and effectiveness of DONZHEIMER 5 TABLET in pediatric patients have not been established.
The most common side effects of taking DONZHEIMER 5 TABLET are diarrhoea, feeling sick, tiredness, difficulty in sleeping, common cold, loss of appetite, hallucinations, and aggressive behaviour. Consult your doctor if any of these above side effects get worse.
USES OF DONZHEIMER 5 TABLET

Used to treat mild to moderately severe Alzheimer?s dementia

HOW DONZHEIMER 5 TABLET WORKS
DONZHEIMER 5 TABLET belongs to cholinesterase inhibitor which works by increasing the levels of a chemical messenger (acetylcholine) involved in transmission of nerve signals. This improves memory and thinking. Memory loss in Alzheimer?s disease occurs due to disturbances of signal transmission in the brain.
DIRECTIONS FOR USE
Take DONZHEIMER 5 TABLET as advised by your physician. Swallow DONZHEIMER 5 TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF DONZHEIMER 5 TABLET

COMMON

Diarrhea

Nausea

Headache

Muscle cramp

Tiredness

Difficulty in sleeping (insomnia)

Common cold

Loss of appetite

Hallucinations

Unusual dreams including nightmares

Agitation

Aggressive behaviour

Fainting, dizziness

Indigestion

Vomiting

Rash, itching

Passing urine uncontrollably

Pain

UNCOMMON

Slow heartbeat

RARE

Uncontrollable or shaky movements with stiffness on the face and tongue which may also involve limbs

Irregular heartbeats
Stop taking DONZHEIMER 5 TABLET and contact your doctor if you experience any of the following side effects:??????????????????????
Signs of stomach or duodenal ulcers such as stomach pain and indigestion

Signs of bleeding in the stomach or intestines such as passing black tar like stools or visible blood from the rectum

Seizures (fits) or convulsions

Signs of hepatitis (liver damage) such as feeling or being sick, loss of appetite, feeling unwell, fever, itching, yellowing of the skin and eyes, and dark coloured urine

Signs of a neuroleptic malignant syndrome (serious brain disorder) such as fever with muscle stiffness, sweating or a lowered level of consciousness

Signs of rhabdomyolysis such as muscle weakness, tenderness or pain, particularly, if at the same time, you feel unwell, have a high temperature or have dark urine

HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhea and consult your doctor if the symptom gets worse.
Tiredness:
Make sure you take rest and drink plenty of fluids. Avoid or limit the consumption of alcohol. Try to take DONZHEIMER 5 TABLET at a time when you can sit down (or lie down) when the symptoms are at their worst. Try not to drive or use tools or machinery until you feel well.
Dizziness:
Try to rest and relax and get enough sleep. Try to avoid driving or operating any tools or machines while you are feeling dizzy. Limit your consumption of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom does not improve.
Indigestion:
Try to reduce your consumption of tea, coffee, cola or alcohol and lose weight if you are obese. Avoid smoking and do not eat three to four hours before going to bed. Consult your doctor if the symptom does not improve.
Vomiting:
Try to take DONZHEIMER 5 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
WARNING & PRECAUTIONS

PREGNANCY
DONZHEIMER 5 TABLET is generally not recommended for use during pregnancy unless it is considered clearly necessary. Consult your doctor before taking DONZHEIMER 5 TABLET.
BREASTFEEDING
DONZHEIMER 5 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking DONZHEIMER 5 TABLET.
DRIVING AND USING MACHINES
DONZHEIMER 5 TABLET may cause tiredness, dizziness and muscle cramp which could affect your ability to drive or operate machines. If you experience these side effects, do not drive or operate machines. Consult your doctor before taking DONZHEIMER 5 TABLET.
ALCOHOL
Avoid consumption of alcohol while taking DONZHEIMER 5 TABLET because it may alter the effect of this medicine.
KIDNEY
DONZHEIMER 5 TABLET should be used with caution in patients with mild kidney disease. Consult your doctor before taking DONZHEIMER 5 TABLET.
LIVER
DONZHEIMER 5 TABLET is not recommended for use in patients with severe liver disease. It should be used with caution in patients with liver problems or hepatitis. Consult your doctor before taking DONZHEIMER 5 TABLET.
ALLERGY
Do not take DONZHEIMER 5 TABLET if you are allergic to Donepezil or piperidine derivatives such as haloperidol, thioridazine, or any of the other ingredients of this medicine.
LUNGS
DONZHEIMER 5 TABLET should be used with caution in patients with asthma or long-term lung disease. Consult your doctor before taking DONZHEIMER 5 TABLET.
HEART DISEASE
DONZHEIMER 5 TABLET should be used with caution in patients with heart diseases such as irregular or very slow heartbeat, fast heartbeat, abnormal heart rhythms, family history of prolonged QT interval (fast and chaotic heartbeats), had heart failure, or heart attack. Consult your doctor before taking DONZHEIMER 5 TABLET.
OTHERS
Before taking DONZHEIMER 5 TABLET, inform your doctor if you:??????????????? ?????????? ????????
Have low levels of magnesium or potassium in your blood

Have difficulty passing urine

Have stomach or duodenal ulcers

Have seizures (fits) or convulsions
Use in pediatrics:
The safety and effectiveness of DONZHEIMER 5 TABLET in pediatric patients have not been established. Consult your doctor before taking DONZHEIMER 5 TABLET.
Use in geriatrics:
DONZHEIMER 5 TABLET should be used with caution in elderly patients (aged 65 years above). Consult your doctor before taking DONZHEIMER 5 TABLET.
INTERACTIONS
A. Drug-Drug Interactions:
Before taking DONZHEIMER 5 TABLET, inform your doctor, if you are taking any of the following medicine:
Medicines used for heart rhythm problems (Ex. amiodarone, sotalol)

Medicines used for depression (Ex. citalopram, escitalopram, amitriptyline, fluoxetine)

Medicines used for psychosis (Ex. pimozide, sertindole, ziprasidone)

Medicines used for bacterial infections (Ex. clarithromycin, erythromycin, levofloxacin, moxifloxacin, rifampicin)

Medicines used for fungal infections (Ex. ketoconazole)

Other medicines used to treat Alzheimer?s disease (Ex. galantamine)

Medicines used for arthritis (Ex. aspirin, non-steroidal anti-inflammatory (NSAID) drugs such as ibuprofen, or diclofenac sodium)

Anticholinergics medicines (Ex. tolterodine)

Anticonvulsants (Ex. phenytoin, carbamazepine)

Medicines used to treat heart condition (Ex. quinidine, beta-blockers such as propanolol and atenolol)

Muscle relaxants (Ex. diazepam, succinylcholine)

General anesthetics (Ex. propofol, ketamine, thiopental)

Medicines obtained without a prescription (Ex. herbal remedies)
Overdosage:
If you or anyone else accidentally takes too much of DONZHEIMER 5 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling and being sick, drooling, sweating, slow heart rate, low blood pressure (lightheadedness or dizziness when standing), breathing problems, losing consciousness and seizures (fits) or convulsions.
SYNOPSIS

Drug :?? Donepezil

Pharmacological Category :?? Acetyl cholinesterase Inhibitor

Therapeutic Indication :?? Alzheimer disease

Dosage Forms :?? Tablet, Syrup, Orally disintegrating strips

MORE INFORMATION

Keep the medicine out of reach in children

Store DONZHEIMER 5 TABLET at room temperature

FAQs ABOUT DONZHEIMER 5 TABLET
What DONZHEIMER 5 TABLET is used for?
DONZHEIMER 5 TABLET is indicated for the treatment of mild to moderately severe Alzheimer?s dementia.
For how long should I take DONZHEIMER 5 TABLET?
Your doctor might advise you on how long you should continue to take DONZHEIMER 5 TABLET. You will need to consult your doctor from time to time to review your treatment and assess your symptoms.
What happens if you take more DONZHEIMER 5 TABLET than your required dose?
If you or anyone else accidentally takes too much of DONZHEIMER 5 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling and being sick, drooling, sweating, slow heart rate, low blood pressure (lightheadedness or dizziness when standing), breathing problems, losing consciousness and seizures (fits) or convulsions.
What side effects are seen with DONZHEIMER 5 TABLET?
The most common side effects of taking DONZHEIMER 5 TABLET are diarrhoea, feeling sick, tiredness, difficulty in sleeping, common cold, loss of appetite, hallucinations, and aggressive behavior. Consult your doctor if any of these symptoms gets worse. Consult your doctor if any of these symptoms gets worse.
Is it safe to drive after taking DONZHEIMER 5 TABLET?
DONZHEIMER 5 TABLET may cause tiredness, dizziness and muscle cramp which could affect your ability to drive or operate machines. If you experience these side effects, do not drive or operate machines. Consult your doctor before taking DONZHEIMER 5 TABLET.
REFERENCES
1. KD. Tripathi. Central Nervous System Stimulants and Cognition Enhancers. Essentials of medical pharmacology. Seventh edition. 2013. Page ? 490.
2. Eisai Inc. The Effectiveness and Safety of Donepezil Hydrochloride (E2020) In Subjects with Mild to Severe Alzheimer?s Disease Residing in An Assisted Living Facility. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in September 2018] [Accessed on 5th May 2022] https://clinicaltrials.gov/ct2/show/NCT00571064
3. Ben Seltzer. Donepezil: a review. NIH National Library of Medicine, National center for biotechnology information. October 2005. [Accessed on 5th May 2022] https://pubmed.ncbi.nlm.nih.gov/16863459/
4. Eisai Inc. U.S. Food & Drug Administration. [Revised in February 2012] [Accessed on 5th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020690s035,021720s008,022568s005lbl.pdf
PRODUCT DETAILS

Country Of Origin

India

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