Famotak 40 mg ( famotidine ) 20 film-coated tablets

Compasition:

Each tablets Contains:

Famotidine ……….20 / 40 mg

Properties:

Famotak is a thiazide derivative of histamine.

It is a histamine H2 receptor antagonist that inhibits gastric acid secretion elicited by histamine or by gastrin.

Famotak inhibits basal (fasting), nocturnal acid secretion & that stimulated by food, fundic distention & various pharmacological agents.

Both the acid concentration & volume of gastric secretion are suppressed by Famotak, while changes in pepsin secretion are proportional to volume output.

The duration of inhibition of secretion after doses of 20 & 40 mg is usually 10 – 12 hours respectively.

Famotak is readily absorbed from the gastro-intestinal tract.

Bioavailability of oral doses is 40 – 45 %, this may be increased slightly by food or decreased slightly by antacids.

After oral doses, peak plasma levels are achieved within 1 – 3 hours.

Peak plasma level is not altered by chronic administration & elimination half life is 2.5 – 3.5 hours. It is eliminated largely unchanged by the renal route (65 – 70 %) & the remainder by metabolic routes. Famotak has no androgenic action. It does not affect prolactin levels, or sex hormones.

Indications:

Short term treatment of active gastric & duodenal ulcer.

Prevention of duodenal ulcer recurrence in selected patients.

Gastric hypersecretory conditions: in treatment of pathological gastric hyper-secretion associated with Zollinger-Ellison syndrome, systemic mastocytosis & multiple endocrine adenomas.

Symptomatic treatment of Gastro- Esophageal Reflux disease

Treatment of upper gastro-intestinal bleeding secondary to gastric ulcer, duodenal ulcer, or hemorrhage gastritis.

With NSAIDs & in minor digestive complains (eg. Chronic episodic dyspepsia).

Dosage :

For duodenal ulcer treatment : 40 mg once daily at bedtime or 20mg twice daily.

For prophylaxis of recurrent duodenal ulcer : 20 mg once daily at bed time

For treatment of benign gastric ulcer : 40 mg once daily at bedtime.

For treatment of gastro-esophageal reflux disease: 20 mg twice daily

Ulcerative esophagitis: 20 or 40 mg twice daily.

With NSAIDs & in minor digestive complains (eg. Chronic episodic dyspepsia) : 20 or 40 mg daily.

Pathological gastric hyper secretion: associated with Zollinger-Ellison syndrome, systemic mastocytosis & multiple endocrine adenomas : 20 mg every 6 hours, the dosage being adjusted as needed & therapy continued for as long as clinically indicated.

Presentation :

Box of 20 tablets of Famotak 20 mg.

Box of 10 & 20 tablets of Famotak 40 mg.