FLOGORIN 25000 Injection 5ml Allschoolabs -

Description

INTRODUCTION
FLOGORIN 25000 INJECTIONcontains Heparin which belongs to theroup of medicines called Anticoagulants. It is used to treat blood clots in leg veins (deep vein thrombosis), blood clots in the lung (pulmonary embolism), chest pains resulting from disease of the heart arteries (unstable angina pectoris), severe blockages affecting arteries in the legs (acute peripheral arterial occlusion).
FLOGORIN 25000 INJECTION is also used during heart, lung operations, during kidney dialysis and prevention of blood clots in the heart following a heart attack (mural thrombosis). A blood clot or thrombus is ael-like collection of blood that form in arteries or veins when blood changes from liquid to partially solid form.
FLOGORIN 25000 INJECTION is not recommended for use if you have liver disease, serious bleeding problems, haemophilia, bruise easily, high blood pressure, tuberculosis, major trauma, have had severe skin problems resulting from previous heparin treatment, surgery of the brain, spine or eye, a lumbar puncture or receiving anesthetic, had an operation, thrombocytopenia, bleeding into the brain, drink a lot of alcohol.
Before receiving FLOGORIN 25000 INJECTIONinform your doctor if you have kidney disease, diabetes, a condition that makes you bleed easily, or suffer from excess acid or high levels of potassium in your blood. Do not consume alcohol, tobacco, or smoke during this treatment.
FLOGORIN 25000 INJECTION should be used with caution in pregnant and breastfeeding women. FLOGORIN 25000 INJECTION is not recommended for use in premature and newborn babies (up to 4 weeks old). Ask for your doctor?s advice.
FLOGORIN 25000 INJECTION should be used with caution in elderly patients above 60 years of age. The most common side effects of receiving FLOGORIN 25000 INJECTION are red lumps or red, itchy patches like eczema at injection site. Consult your doctor if symptoms do not show improvement.
USES OF FLOGORIN 25000 INJECTION
To treat,
Deep vein thrombosis

Pulmonary embolism

Acute peripheral arterial occlusion

Unstable angina pectoris

Prevent clots during heart, lung operations, kidney dialysis

Mural thrombosis

HOW FLOGORIN 25000 INJECTION WORKS
FLOGORIN 25000 INJECTION binds to the antithrombin (an enzyme present in the clotting system) which in turn inhibits several clotting factors such as factor Xa, factor IIa. This inactivation of thrombin prevents the formation of clots and prolongs the clotting time of blood.
DIRECTIONS FOR USE
FLOGORIN 25000 INJECTION will beiven to you only by a doctor or a nurse into a vein as an intravenous infusion. It should not beiven into a muscle. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
SIDE EFFECTS OF FLOGORIN 25000 INJECTION

COMMON

Red lumps or red, itchy patches like eczema at the injection site

RARE

Raised levels of potassium in the blood, particularly in patients with kidney failure or diabetes (feel tired and weak)

Irritation or sloughing of skin at the injection site
Stop receiving FLOGORIN 25000 INJECTION and contact your doctor immediately if you experience any of the following side effects:
Severe allergic reactions (itchy skin rash, eye irritation, runny nose, wheezing, rapid breathing, blue tinge to the lips, fever, chills, swelling of the eyes and lips, and shock)

Thrombocytopenia may result in the formation of dangerous blood clots causing chest pains, shortness of breath, coughing, dizziness or loss of consciousness

Signs of developing paralysis (after having an epidural or spinal anesthetic, tingling, weakness or numbness in legs or lower body, back pain, incontinence of urine or back passage)

Unusual bruising or purple spots on skin, unusual bleeding fromums, nose, urine, stool, or injury

HOW TO MANAGE SIDE EFFECTS
Itchy skin:
Hot water makes your skin irritated, so avoid taking hot showers. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. To soothe and hydrate irritated skin, apply moisturizers. Contact your doctor if the itching worsens.
WARNING & PRECAUTIONS

PREGNANCY
FLOGORIN 25000 INJECTION should be used with caution in pregnant women. Inform your doctor or nurse know prior to receiving FLOGORIN 25000 INJECTION if you are pregnant, wish to become pregnant or have a history of, or known risk to miscarriage. If FLOGORIN 25000 INJECTION isiven, bleeding may be a problem during pregnancy or after delivery. Your bones mayet thinner if you receive FLOGORIN 25000 INJECTION for a long-time during pregnancy. If you are pregnant and areoing to have an epidural anesthetic, you should stop having the medicine. Consult your doctor before receiving it.
BREASTFEEDING
FLOGORIN 25000 INJECTION should be used with caution in breastfeeding women as it will beiven to you after evaluating the risk and benefit ratio. Consult your doctor before receiving it.
DRIVING AND USING MACHINES
FLOGORIN 25000 INJECTION does not affect your ability to drive or use machines.
ALCOHOL
Do not consume alcohol while receiving FLOGORIN 25000 INJECTION.
KIDNEY
FLOGORIN 25000 INJECTION should be used with caution patients having kidney disease, dose will be adjusted by your doctor. Consult your doctor before receiving it.
LIVER
FLOGORIN 25000 INJECTIONis not recommended for use in patients who suffer from severe liver problems which can lead to bleeding into the esophagus. FLOGORIN 25000 INJECTION should be used with caution in mild to moderate liver disease, dose will be adjusted by your doctor. Consult with your doctor before receiving FLOGORIN 25000 INJECTION.
ALLERGY
Do not receive FLOGORIN 25000 INJECTION if you are allergic to Heparin or any other ingredients of this medicine.
OTHERS
FLOGORIN 25000 INJECTION is not recommended for use if you:
Drink large amounts of alcohol

Have high blood pressure

Are bleeding from anywhere in the body (apart from your normal periods)

Have hemophilia (aenetic disorder) or any other bleeding problem

Have or have ever had thrombocytopenia (prevents blood from clotting properly)

Bruise easily or have lots of purple spots that look like bruises (purpura)

Are suffering from tuberculosis (TB)

Have had severe skin problems resulting from previous treatment with heparin

Are about to have surgery of the spine or eye, brain, or a lumbar puncture

Have recently had an operation

Have bleeding into the brain
Before receiving FLOGORIN 25000 INJECTION, inform your doctor if you:
Are having an epidural or spinal anesthetic

Have any condition which makes you likely to bleed more easily (stomach ulcer, hiatus hernia, inflammation of the heart, problems in the back of your eye, piles, a stroke, cancer or threatened miscarriage)

Suffer from diabetes

Suffer from excess acid or high levels of potassium in your blood

Smoke
Use in pediatrics:
FLOGORIN 25000 INJECTION is not recommended for use in premature and newborn babies (up to 4 weeks old). Consult with your child?s doctor.
Use ineriatrics:
FLOGORIN 25000 INJECTIONshould be used with caution in elderly patients above 60 years of age. Dose will be adjusted by your doctor. Consult your doctor before receiving it.
INTERACTIONS
A. Drug ? Drug interactions:
Before receiving FLOGORIN 25000 INJECTION, inform your doctor if you are taking any of the following medicine:
Medicines used to treat pain and inflammation (Ex. diclofenac (especially intravenous), ibuprofen, aspirin)

Medicines used to treat shock (Ex. dextran solutions)

Medicines which may interfere with clotting of the blood (Ex. dipyridamole, epoprostenol, clopidogrel or streptokinase)

Medicines used to treat infections (Ex. cephalosporins,entamicin, amikacin, neomycin or tobramycin)

Medicines used to treat high blood pressure or heart problems (Ex. captopril enalapril, lisinopril, ramipril, losartan or valsartan, aliskiren)

Medicines that may increase the potassium level in blood (Ex. amiloride, triamterene, eplerenone or spironolactone)

Glyceryl trinitrateiven into a vein (used for coronary heart disease)

Medicines used to treatout (Ex. probenecid)
Overdosage:
FLOGORIN 25000 INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms like severe bleeding.
SYNOPSIS

Drug :?? Heparin

Pharmacological Category :?? Anticoagulant

Therapeutic Indication :?? Blood clots

Dosage Forms :??el, Injection, Solution, Topical solution

MORE INFORMATION

Keep FLOGORIN 25000 INJECTION out of reach of children

Store FLOGORIN 25000 INJECTION at room temperature below 25?C

FAQs ABOUT FLOGORIN 25000 INJECTION
Can FLOGORIN 25000 INJECTION be received by children?
FLOGORIN 25000 INJECTION is not recommended for use in premature and newborn babies (up to 4 weeks old). Dose will be adjusted by your doctor depending on your age, body weight and disease condition. Consult your doctor before receiving
Can FLOGORIN 25000 INJECTION be received by pregnant women?
FLOGORIN 25000 INJECTION should be used with caution in pregnant women. Inform your doctor or nurse know prior to receiving FLOGORIN 25000 INJECTION if you are pregnant, wish to become pregnant or have a history of, or known risk to miscarriage. If FLOGORIN 25000 INJECTION isiven, bleeding may be a problem during pregnancy or after delivery. Your bones mayet thinner if you receive FLOGORIN 25000 INJECTION for a long-time during pregnancy. If you are pregnant and areoing to have an epidural anesthetic, you should stop having the medicine. Consult your doctor before receiving it.
Can I smoke while receiving FLOGORIN 25000 INJECTION?
Avoid smoking while receiving FLOGORIN 25000 INJECTION. Tobacco smoke can also interfere with the working of FLOGORIN 25000 INJECTION. Ask for your doctor?s advice and inform your doctor if you smoke.
Can I Keep receiving FLOGORIN 25000 INJECTION if I have a planned surgery?
You must remind your doctor that you are having FLOGORIN 25000 INJECTION before you receive any anesthetic. After you have the anesthetic your doctor or nurse might make regular checks to make sure you are notetting any major bleeding or bruising around your spine which may cause paralysis that could be permanent. After you have the anesthetic, your doctor will tell you when you can take FLOGORIN 25000 INJECTION again.
Do I need to undergo any diagnostic tests while receiving FLOGORIN 25000 INJECTION?
The presence of FLOGORIN 25000 INJECTION in the blood can affect the results of some blood tests such as thyroid tests and the levels of calcium or some antibiotics such asentamicin in the blood. Your doctor might ask you to take several diagnostic tests.
Will I beiven a test dose of FLOGORIN 25000 INJECTION?
If you suffer from allergies or have previously had an allergic reaction to heparin, a small test dose of FLOGORIN 25000 INJECTION may beiven first to make sure that you are not allergic to it.
REFERENCES
1. KD Tripathi. Drugs Affecting Coagulation, Bleeding and Thrombosis. Essentials of medical pharmacology. Eighth Edition. 2019. Page ?663-664
2. Mandana Izadpanah, Hossein Khalili, Mostafa Mohammadi. Comparing safety of heparin as continuous intravenous infusion and multiple subcutaneous injections. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed.gov. December 2015. [Accessed on 10th August 2022] https://pubmed.ncbi.nlm.nih.gov/26689885/
3. Eziafa, Oduah, Robert J. Linhardt, and Susan T. Sharfstein. Heparin: Past, Present, and Future. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed Central. September 2016. [Accessed on 10th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039491/
4. CP Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in June 2018] [Accessed on 10th August 2022] https://www.medicines.org.uk/emc/files/pil.1678.pdf
5. CP Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in June 2018] [Accessed on 10th August 2022] https://www.medicines.org.uk/emc/files/pil.1680.pdf
6. Fresenius Kabi. U.S. Food & Drug Administration. [Revised in August 2017] [Accessed on 10th August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/017029s140lbl.pdf
7. Pfizer Laboratories Div Pfizer Inc. Heparin Sodium. Dailymed. [Revised in May 2020]. [Accessed on 10th August 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=56dc3074-f1c5-45a3-b923-f1d14858e06d
8. Troikaa Pharmaceuticals. Cathflush (Heparin Sodium). [Accessed on 10th August 2022] https://www.troikaa.com/wp-content/uploads/2021/10/Common-Products-List-Novogen-Excluded.pdf
9. Drug bank. Heparin. [Accessed on 10th August 2022] https://go.drugbank.com/drugs/DB01109
USEFUL DIAGNOSTIC TESTS