Uses & Effectiveness Overview Hordenine is a chemical naturally found in barley (Hordeum vulgare). It can also be found in algae, cacti, and some grass species. It is similar in chemical structure to stimulants found in bitter orange. Hordenine is included in many dietary supplements used for athletic performance and weight loss. People take hordenine by mouth for obesity and improving athletic performance, but there is no good scientific evidence to support these uses. Hordenine, also known as N,N-dimethyltyramine, is a naturally occurring alkaloid found in various plants. It acts as a natural stimulant by increasing energy levels and enhancing mental focus, making it a popular ingredient in pre-workout supplements and weight loss products. Side Effects When taken by mouth: Hordenine is POSSIBLY UNSAFE. Hordenine is similar in structure to stimulants found in bitter orange. In theory, hordenine might have similar stimulant effects and side effects such as rapid heart rate and high blood pressure. Interactions Moderate Interaction Be cautious with this combination Medications for depression (MAOIs) interacts with HORDENINE Hordenine might stimulate the body. Some medications used for depression can increase chemicals that also have stimulant effects. Taking hordenine with these medications used for depression might cause serious side effects including fast heartbeat, high blood pressure, seizures, nervousness, and others. Some of these medications used for depression include isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Stimulant drugs interacts with HORDENINE Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Hordenine might also speed up the nervous system. In theory, taking hordenine along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with hordenine. Some stimulant drugs include amphetamine, caffeine, methylphenidate, pseudoephedrine, and many others. Special Precautionsand Warnings When taken by mouth: Hordenine is POSSIBLY UNSAFE. Hordenine is similar in structure to stimulants found in bitter orange. In theory, hordenine might have similar stimulant effects and side effects such as rapid heart rate and high blood pressure. Pregnancy and breast-feeding: There isn?t enough reliable information to know if hordenine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use. High blood pressure: Hordenine is similar to stimulants found in bitter orange. In theory, taking hordenine might make high blood pressure worse. Kidney stones: Taking hordenine might increase the risk for kidney stones. Surgery: Hordenine might interfere with surgery by increasing blood pressure and heart rate. Stop taking hordenine at least 2 weeks before surgery. Dosing The appropriate dose of hordenine depends on several factors such as the user?s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hordenine (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.