Hyalone 60mg Injection 4ml Allschoolabs -

Description

INTRODUCTION
HYALONE 60MG contains Sodium hyaluronate which belongs to theroup of medicine called viscoelastic supplements. It is used to treat pain in knee osteoarthritis among patients who have failed to respond adequately to simple analgesics and conservative non-pharmacologic therapy. Sodium hyaluronate is available as a salt form of hyaluronic acid. Hyaluronic acid is a natural polysaccharide present in very high amounts in the synovial fluid (fluid surrounding the joint) and acts as a lubricant and shock absorber in between joints.
People with knee osteoarthritis suffer a very low concentration of hyaluronic acid in their synovial fluid. Intra-articular administration of HYALONE 60MG supplements hyaluronic acid to the synovial fluid and lubricates and cushions the joint. It also provides relief from joint friction and pain. It helps in absorption of shock created from normal physical activity like walking, running, jumping etc. This medicine should only beiven as an intra-articular injection (in between joints). People taking this injection, or any other visco-supplementation should be advised to avoid any prolonged (for more than an hour) or strenuous activities (like lifting heavy weights, running, jumping) within 48 hours following intra-articular injection. Before administration, remove any joint effusion if present.
The most common side effect of this medicine are injection site reactions such as joint pain, swelling, redness and warmth. Contact your doctor if these symptom bothers you. HYALONE 60MG is not recommended for use in pregnant or breastfeeding women and children under 18 years of age. Consult your doctor before taking. Before taking this medicine, inform your doctor if you have liver disease or had it in the past. Do not take this medicine, if you have any infection or inflammation at the joint cavity. Consult your doctor before taking.
USES OF HYALONE 60MG

Treats osteoarthritis of the knee

HOW HYALONE 60MG WORKS
In people with knee osteoarthritis, intra-articular administration of HYALONE 60MG supplements the required amount of hyaluronic acid directly into the synovial fluid. This leads to enhanced joint lubrication and absorption of shock created from normal physical activity like walking, running, cycling or jumping. As a result, friction in between joint and pain are relieved.
DIRECTIONS FOR USE
This medicine will beiven to you only by an orthopedic surgeon in between the joints (intra-articular injection). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and health condition. Strict aseptic condition must be followed during the process.
Before administration, remove any joint effusion if present. Do not inject this medicine intravascularly because it may lead to unwanted systemic side effects. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
SIDE EFFECTS OF HYALONE 60MG

COMMON

Injection site reactions (such as joint pain, swelling, redness and warmth)

Nasopharyngitis

Upper respiratory tract infections, fever

Pain in extremity

Cystitis

Nausea, diarrhea, dyspepsia

Paresthesia (numbness of arms, legs or feet)

Musculoskeletal pain

Plantar fasciitis (pain of heels of feet)

HOW TO MANAGE SIDE EFFECTS
Nausea:
Try taking this medicine with, or just after meals. Stick to simple meals. Do not eat rich or spicy food.
Diarrhea:
Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.
Musculoskeletal pain:
Try to rest and relax. Keep a hot pack on the affected area, as it may ease the pain. Avoid walking or jogging while you are feeling uncomfortable. If your symptom does notet better, speak to your doctor.
WARNING & PRECAUTIONS

PREGNANCY
HYALONE 60MG is not recommended for use in pregnant women due to lack of safety data. Consult your doctor for advice.
BREASTFEEDING
HYALONE 60MG is not recommended for use in breastfeeding women due to lack of safety data. Consult your doctor for advice.
LIVER
HYALONE 60MG should be taken with caution in patients with liver disease. Consult your doctor for advice.
ALLERGY
Do not take this medicine if you are allergic to sodium hyaluronate.
OTHERS
Do not take this medicine, if you have:
Any infection or inflammation at the joint cavity or any other skin disease at the site of injection (knee)

INTERACTIONS
Talk to your doctor, if you are taking,
Quaternary ammonium salts or chlorhexidine (used as topical disinfectants)

SYNOPSIS

Drug :?? Sodium hyaluronate

Pharmacological Category :?? Viscoelastic substance, Ophthalmic lubricants,?Dermatological agent, Pharmaceutical aid

Therapeutic Indication :?? Knee osteoarthritis

Dosage Forms :?? Tablet, Capsule, Cream,el, Eye drops,?Ophthalmic injectable solution,?Injection

MORE INFORMATION
Store in a refrigerator at 2-8?C?and keep out of reach of children.
FAQs ABOUT HYALONE 60MG
Can HYALONE 60MG cause joint swelling?
Yes. Although this medicine is used to treat joint pain, it may cause joint swelling in some individuals. Contact your doctor if this symptom bothers you.
How to take HYALONE 60MG?
It is not meant for self-administration. It will beiven to you only by an orthopedic surgeon in between the joints (intra-articular injection). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and health condition.
Who should take HYALONE 60MG?
It is recommended for use in patients who have failed to respond adequately to simple analgesics and conservative non-pharmacologic therapy.
REFERENCES
1. Harsh Mohan. The Musculoskeletal system. Joints. Textbook of Pathology. 6th Edition. 2010. Page ? 850- 851.
2. Ferring Pharmaceuticals. Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on June 2012] [Accessed 18th December 2020]?https://clinicaltrials.gov/ct2/show/NCT00988091
3. A S Dixon,?R K Jacoby,?H Berry,?E B Hamilton. Clinical trial of intra-articular injection of sodium hyaluronate in patients with osteoarthritis of the knee. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 1988. [Accessed 18th December 2020]?https://pubmed.ncbi.nlm.nih.gov/3063436/
4. Emmanuel Maheu, Bernard Avouac, Ren?e Liliane Dreiser and Thomas Bardin. A single intra-articular injection of 2.0% non-chemically modified sodium hyaluronate vs 0.8% hylan-F 20 in the treatment of symptomatic knee osteoarthritis: A 6-month, multicenter, randomized, controlled non-inferiority trial. PLOS ONE. December 2019. [Accessed 18th December 2020]?https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226007
5. Hanmi Pharm Co., Ltd. U.S. Food & Drug Administration. [Accessed 18th December 2020]?https://www.accessdata.fda.gov/cdrh_docs/pdf17/P170016D.pdf
6.?Savient Pharmaceuticals, Inc. U.S. Food & Drug Administration. [Accessed 18th December 2020]?https://www.accessdata.fda.gov/cdrh_docs/pdf/p010029b.pdf
7. Fidia Farmaceutici S.p.A. Health Products Regulatory Authority (HPRA). [Revised on December 2009] [Accessed 18th December 2020]?https://www.hpra.ie/img/uploaded/swedocuments/LicenseSPC_PA0814-001-001_05042016103037.pdf
8. Fidia Farmaceutici S.p.A. Hyalgan.com. [Revised on May 2014] [Accessed 18th December 2020]?https://hyalgan.com/wp-content/uploads/2016/02/hyalgan_pi.pdf
9. Cipla. Ltd. HYRUAN OneTM?Injection?(Cross-linked Hyaluronic Acid 20mg/mL). Ciplamed.com [Revised on January 2019] [Accessed 18th December 2020]?https://ciplamed.com/content/hyruan-onetm-injection
10.enzyme Biosurgery, A division ofenzyme Corporation. SYNVISC ONE? HYLAN-F 20. [Revised on September 2014] [Accessed 18th December 2020]?https://products.sanofi.us/synviscone/synviscone.html
11. Central Drugs Standard Control Organisation (CDSCO). Sodium Hyaluronate Injection 8mg/vial (6ml Pre-filled syringe for Intra Articular use only). [Revised on April 2012] [Accessed 18th December 2020]?https://cdscoonline.gov.in/CDSCO/Drugs
USEFUL DIAGNOSTIC TESTS