INTRODUCTION
IPRASURE INHALER is a combination of Ipratropium and Levosalbutamol which belongs to theroup of medicines called Bronchodilator agents and Adrenergic beta-agonists, respectively. IPRASURE INHALER is used in adults, adolescents, and children (aged 4 years and above) to treat/prevent bronchospasm (tightening of airway muscles) with reversible obstructive airway diseases such as asthma, COPD (inflammatory lung disease), bronchitis (inflammation of airways), and/or emphysema (lung disease that cause shortness of breath).
IPRASURE INHALER is not recommended for use in patients allergic to ipratropium, levosalbutamol, and/or atropine.
Before using IPRASURE INHALER, inform your doctor if you have high blood pressure, seizures, diabetes, narrow anglelaucoma (increased eye pressure), lung problems (such as asthma), heart problems (such as coronary insufficiency, cardiac arrhythmias), kidney problems (such as renal impairment), and/or liver problems (such as hepatic impairment).
IPRASURE INHALER isenerally not recommended for use in pregnant women unless it is clearly necessary. It is advised to be used with caution in breastfeeding women only if necessary since it is not known whether the medicine passes through breast milk.
IPRASURE INHALER should be used with caution in children and adolescents (aged 4 to 18 years) and is advised to be used with caution in elderly patients (aged above 65 years) after consulting the doctor.
The most common side effects using IPRASURE INHALER are dry mouth, sore throat, stuffy nose, throat irritation, dizziness, headache, nausea, and/or vomiting. Consult your doctor if any of these symptoms worsens.
USES OF IPRASURE INHALER

Treats/prevents bronchospasm with reversible obstructive airway diseases such as asthma, COPD, bronchitis, and/or emphysema in affected individuals

HOW IPRASURE INHALER WORKS
IPRASURE INHALER provides ease in breathing from bronchospasm (constricted airway muscles), where Ipatropium and Levosalbutamol work together to relax airway muscles which results in widening of airways providing relief from obstructive airflow and easy in breathing from bronchospasm associated with reversible obstructive airway diseases (such as asthma, COPD) in affected individuals.
DIRECTIONS FOR USE
Take IPRASURE INHALER as advised by your physician. It is for inhalation use only. Remove the cap and shake the inhaler. Insert the inhaler into spacer and breath out. Press down the inhaler and breath in slowly through the inhaler. Hold your breath for a count of 10 and slowly breath out. Close the inhaler after use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF IPRASURE INHALER

COMMON

Dry mouth, sore throat, stuffy nose, throat irritation

Dizziness, headache, weakness

Abdominal pain, nausea, vomiting, diarrhoea, constipation

Muscle pain/cramps, back pain

Stuffy nose, shortness of breath, cough, sinusitis (inflammation of sinus)

Altered taste

Stomach flu, urinary tract infection

Conjunctivitis, ear pain, blurred vision, acne

Dysmenorrhoea (menstrual cramps)

High blood pressure

Nosebleed

Skin rash, itching, red itchy welts

Swelling of face/mouth/throat

UNCOMMON

Dysphonia (disorders of voice)

Indigestion

RARE
Stop taking IPRASURE INHALER and contact your doctor immediately if you experience any of the following side effects:
Signs of paradoxical bronchospasm (sudden constriction of airways after using medicine) such as shortness of breath, coughing, and/or wheezing

Signs of sudden hypersensitivity reaction (immune mediated allergic reaction) such as red itchy welts, swelling of face/mouth/tongue, bronchospasm (tighten airways), and/or rash

Signs of acute narrow anglelaucoma (rapid/sudden increase in eye pressure) such as eye pain/discomfort, blurred vision, visual halos, and/or colored images in association with red eyes

Signs of prostatic hyperplasia/urinary bladder neck obstruction such as difficulty in passing urine, painful urination

Signs of significant cardiovascular effects measured by pulse rate, blood pressure, and/or other symptoms

HOW TO MANAGE SIDE EFFECTS
Dry mouth:
Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and use mouthwash. Consult and inform your doctor if the symptomets worse.
Dizziness:
Try to rest andet enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
Headache:
If IPRASURE INHALER causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usuallyo away after the first week of taking IPRASURE INHALER. If it lasts more than a week or severe, inform your doctor.
Nausea and vomiting:
Take IPRASURE INHALER with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.
Constipation:
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate treatments for constipation.
Diarrhoea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult and inform your doctor if the symptom worsens.
Indigestion:
Try to have smaller and more frequent meals and drink slowly. Reduce consumption of coffee, cola, tea, or alcohol and lose weight if you are obese.? Try to avoid smoking and don?t have rich, fatty or spicy foods. Consult your doctor and inform if the symptom does not improve.
WARNING & PRECAUTIONS

PREGNANCY
IPRASURE INHALER isenerally not recommended for use in pregnant women unless it is clearly necessary.? Consult your doctor before using IPRASURE INHALER.
BREASTFEEDING
IPRASURE INHALER should be used with caution in breastfeeding women only if clearly necessary since it is unknown whether the medicine passes through breast milk. Consult your doctor before using the medicine.
DRIVING AND USING MACHINES
Do not drive/operate machines if you feel dizzy, and/or experience accommodation disorder, dilated pupils/blurred vision while using IPRASURE INHALER.
KIDNEY
IPRASURE INHALER should be used with caution in patients with kidney problems such as renal impairment. Consult your doctor before using IPRASURE INHALER.
LIVER
IPRASURE INHALER should be used with caution in patients with liver problems such as hepatic impairment. Consult your doctor before using IPRASURE INHALER.
ALLERGY
Do not take IPRASURE INHALER if you are allergic to ipratropium, levosalbutamol, atropine, and/or any other ingredients of the medicine.
LUNGS
IPRASURE INHALER should be used with caution in patients with lung problems such as asthma. Consult your doctor before using the medicine.
HEART DISEASE
IPRASURE INHALER should be used with caution in patients with heart problems such as coronary insufficiency, cardiac arrhythmias. Consult your doctor before using IPRASURE INHALER.
OTHERS
Before using IPRASURE INHALER inform your doctor if you:
Have high blood pressure

Have seizures

Suffer from hyperthyroidism (overactive thyroid)

Have diabetes

Have narrow anglelaucoma (increased eye pressure)

Suffer from prostatic hypertrophy (enlarged prostateland)

Suffer from bladder-neck obstruction
Use in Paediatrics:
IPRASURE INHALER is advised to be used with caution in children and adolescents (aged 4 to 18 years). Consult your doctor before using the medicine.
Use ineriatrics:
IPRASURE INHALER should be used with caution in elderly patients (aged above 65 years). ?Consult your doctor before using the medicine.
INTERACTIONS
A. Drug-Drug interactions:
Before using IPRASURE INHALER, inform your doctor if you are taking any of the following medicine:
Medicines used to treat high blood pressure such as beta-adregenic/receptor blocking agents (Ex. propanolol, metoprolol, atenolol)

Anticholinergic agents (medicines used to block acetylcholine) Ex. atropine, benztropine

Diuretics (used to treat high blood pressure) Ex. chlorothiazide, chlorthalidone

Monoamine oxidase inhibitors/tricyclic antidepressants (medicines used to treat depression) Ex. selegiline, phenelzine, amitriptyline, imipramine
B. Drug?Food interactions:
IPRASURE INHALER is not recommended for use in patients allergic to soyabean, and/or other related food products such as peanut.
Overdosage:
If you or anyone else accidentally take too much of IPRASURE INHALER, then consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are seizures, chest pain, high/low blood pressure, fast heartbeat, irregular heartbeats, nervousness, headache, tremor, dry mouth, palpitation, nausea, dizziness, fatigue, weakness, sleeplessness, hypokalaemia (low potassium level in blood), and/or visual accommodation disorder.
SYNOPSIS

Drug :?? Ipratropium bromide, Levosalbutamol

Pharmacological Category :?? Bronchodilator agents, Adrenergic beta-agonists

Therapeutic Indication :?? Bronchospasm with reversible obstructive airway diseases?(such as asthma, COPD, bronchitis, and/or emphysema)

Dosage Forms :?? Rotacap, Inhalation Capsule, Inhaler, Respules, Smartule, Mistpules, Transpule

MORE INFORMATION

Keep IPRASURE INHALER out of reach of children

Do not store IPRASURE INHALER above 30?C

FAQs ABOUT IPRASURE INHALER
What is IPRASURE INHALER used for?
IPRASURE INHALER is used in adults, adolescents, and children (aged 4 years and above) to treat/prevent bronchospasm (tightening of airway muscles) with reversible obstructive airway diseases such as asthma, COPD (inflammatory lung disease), bronchitis (inflammation of airways), and/or emphysema (lung disease that cause shortness of breath).
What are the side effects of IPRASURE INHALER?
The most common side effects using IPRASURE INHALER are dry mouth, sore throat, stuffy nose, throat irritation, dizziness, headache, nausea, and/or vomiting. Consult your doctor if any of these symptoms worsens.
How IPRASURE INHALER works?
IPRASURE INHALER provides ease in breathing from bronchospasm (constricted airway muscles), where Ipatropium and Levosalbutamol work together to relax airway muscles which results in widening of airways providing relief from obstructive airflow and easy in breathing from bronchospasm associated with reversible obstructive airway diseases (such as asthma, COPD) in affected individuals.
How IPRASURE INHALER should be administered?
Take IPRASURE INHALER as advised by your physician. It is for inhalation use only. Remove the cap and shake the inhaler. Insert the inhaler into spacer and breath out. Press down the inhaler and breath in slowly through the inhaler. Hold your breath for a count of 10 and slowly breath out. Close the inhaler after use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Can IPRASURE INHALER be used in pregnant and breastfeeding women?
No, IPRASURE INHALER isenerally not recommended for use in pregnant women unless it is clearly necessary. It should be used with caution in breastfeeding women only if necessary since it is not known whether the medicine pass through breast milk. Consult your doctor before using IPRASURE INHALER.
REFERENCES
1. K.D. Tripathi. Anticholinergic Drugs and Drugs Acting on Autonomicanglia. Essentials of medical pharmacology. Seventh edition. 2013. Page- 116.
2. Hongzhen Xu,?Lin Tong,?Pengao,??Yan Hu,?Huijuan Wang,?Zhimin Chen,?Luo Fang. Combination of ipratropium bromide and salbutamol in children and adolescents with asthma: A meta-analysis. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in February 2021] [Accessed on 27th May 2022]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901745/
3. CiplaMed. DUOLIN Inhaler. [Revised in April 2019] [Accessed on 27th May 2022]?https://www.ciplamed.com/content/duolin-inhaler
4. CiplaMed. DUOLIN forte Inhaler.[Accessed on 27th May 2022]?https://www.ciplamed.com/product-index-listing?field_speciality_tid=All&field_other_specialty_tid=All&field_brand_value=&field_molecule_value=levo
USEFUL DIAGNOSTIC TESTS

Spirometry

Chest X-ray

CT scan

PRODUCT DETAILS

Country Of Origin

India

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