IVASAFE 5 Tablet 10?s Allschoolabs -

Specification

INTRODUCTION
IVASAFE 5 TABLET contains Ivabradine which belongs to theroup of medicines called Hyperpolarization-activated cyclic nucleotide-gated channel blockers. IVASAFE 5 TABLET is used to treat symptomatic stable angina pectoris (chest pain) in adult patients who are intolerant/incapable to take heart medicines (such as beta blockers) and whose heart rate is over/equal to 70 beats per minute.
It is also used to treat chronic heart failure in adult patients whose heart rate is over/equal to 75 beats per minute which are used as a combination therapy with beta-blockers or in adult patients who are contraindicated to use beta blockers.
IVASAFE 5 TABLET is not recommended for use in patients allergic to ivabradine. It is also not recommended for use in patients suffering from very low blood pressure, heart problems (such as unstable angina, cardiogenic shock), severe kidney disease, and/or severe liver disease.
Before taking IVASAFE 5 TABLET, inform your doctor if you have mild to moderate low blood pressure, chronic eye retinal disease, recent stroke (cerebral attack), heart rhythm disorders (such as irregular heartbeat, palpitation, increase in chest pain), and/or moderate liver disease.
IVASAFE 5 TABLET isenerally not recommended for use in pregnant and breast-feeding women which is also not recommended for use in children and adolescents (aged below 18 years). The medicine is advised to be used with caution in elderly patients (aged above 65 years) after consulting the doctor.
The most common side effects of taking IVASAFE 5 TABLET are brief moments of increased brightness (due to sudden changes in light intensity), slow heart rate, uncontrolled blood pressure, headache, dizziness, and/or blurred vision. Consult your doctor if any of these symptoms worsen.
USES OF IVASAFE 5 TABLET

Symptomatic stable angina pectoris (chest pain) in adult patients (with heart rate above/equal to 70 beats/minute)

Chronic heart failure in adult patients (with heart rate above/equal to 75 beats/minute)

HOW IVASAFE 5 TABLET WORKS
IVASAFE 5 TABLET works by reducing the heart rate which leads to low oxygen requirement of the heart resulting in improved blood supply throughout the body (with each hear beat) thus providing relief from angina pectoris and preventing the occurrence of chronic heart failure in affected individuals.
DIRECTIONS FOR USE
Tablet:
Take IVASAFE 5 TABLET as advised by your physician. Swallow the medicines with alass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Orally Disintegrating Tablet:
Take IVASAFE 5 TABLET as advised by your physician. Place?IVASAFE 5 TABLET?inside your mouth and allow it to dissolve completely. Do not swallow or chew the medicine.. Your physician will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF IVASAFE 5 TABLET

COMMON

Brief moments of increased brightness (due to sudden changes in light intensity)

Slow heart rate

Signs of atrial fibrillation (irregular rapid contraction of heart) such as chest pain, pounding heartbeat, tiredness

Uncontrolled blood pressure

Headache, dizziness, blurred vision

UNCOMMON

Racing heartbeat

Nausea, constipation, diarrhoea, abdominal pain

Sudden internal/external spinning sensation

Difficulty breathing

Muscle spasms

Skin rash

Signs of angioedema such as swollen face, tongue/throat, difficulty in breathing/swallowing

Low blood pressure, fainting, tiredness, weakness

Double vision, impaired vision

RARE

Red itchy welts, itching, skin reddening

Feeling unwell

HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom does not improve.
Dizziness:
Try to rest andet enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
Nausea:
Try to take IVASAFE 5 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptomets worse.
Constipation:
Try to eat high-fibre foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor to receive alternate treatments for constipation.
Diarrhoea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhoea. Consult your doctor and inform them if the symptomets worse.
WARNING & PRECAUTIONS

PREGNANCY
IVASAFE 5 TABLET is not recommended for use during pregnancy and in women planning for pregnancy. Women of childbearing potential should use reliable contraceptive measures while taking IVASAFE 5 TABLET. Consult your doctor before taking the medicine.
BREASTFEEDING
IVASAFE 5 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking the medicine.
DRIVING AND USING MACHINES
Do not drive or operate any machines after taking IVASAFE 5 TABLET since it may cause temporary blindness (due to sudden changes in light intensity) which may after your ability to concentrate while driving or operating machines.
KIDNEY
IVASAFE 5 TABLET should be used with caution in patients with severe kidney disease. Consult your doctor before taking the medicine.
LIVER
IVASAFE 5 TABLET is not recommended for use in patients with severe liver disease. It should be used with caution in patients with moderate liver disease. Consult your doctor before taking the medicine.
ALLERGY
Do not take IVASAFE 5 TABLET if you are allergic to ivabradine, and/or any other ingredients of this medicine.
HEART DISEASE
IVASAFE 5 TABLET is not recommended for use in patients with heart problems such as slow resting heart rate (beats below 70/minute), cardiogenic shock, heart rhythm disorders (such as sick sinus syndrome, sino-atrial block, heart block), heavy heart attack, and/or severe heart failure. It should be used with caution in patients with other heart rhythm disorders (such as irregular heartbeat, palpitation, increase in chest pain), sustained atrial fibrillation, long QT syndrome, slow heartbeat (associated with signs such as tiredness, dizziness, shortness of breath), and/or bundle branch block (type of severe heart failure). Consult your doctor before taking the medicine.
OTHERS
IVASAFE 5 TABLET is not recommended for use if you:
Suffer from very low blood pressure

Have unstable angina (a severe form of chest pain)
Before taking IVASAFE 5 TABLET, inform your doctor if you:
Had a recent stroke (cerebral attack)

Suffer from mild to moderate low blood pressure (after change in antihypertensive treatment)

Have chronic eye retinal disease
Use in Paediatrics:
IVASAFE 5 TABLET isenerally not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before taking the medicine.
Use ineriatrics:
IVASAFE 5 TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking the medicine.
INTERACTIONS
A.Drug ? Drug interactions:
Before taking IVASAFE 5 TABLET, inform your doctor if you are taking any of the following medicine:
Medicines used to treat fungal infections (Ex. fluconazole, ketoconazole, itraconazole)

Rifampicin (medicine used to treat tuberculosis)

Barbiturates (medicines used for difficulty sleeping or epilepsy)

Phenytoin (used for epilepsy)

Hypericum perforatum/St John?s Wort (herbal medicines used for depression)

Medicines used to treat heart rhythm disorders (Ex. quinidine, disopyramide, sotalol, ibutilide, amiodarone)

Bepridil (medicine used to treat angina pectoris)

Medicines to treat anxiety, schizophrenia or other psychoses (Ex. pimozide, ziprasidone, sertindole)

Medicines used to treat malaria (Ex. mefloquine,halofantrine)

Intravenous erythromycin (medicine used to treat bacterial infections in different parts of the body)

Pentamidine (medicine used in the management and treatment?of pneumocystis pneumonia, leishmaniasis, trypanosomiasis)

Cisapride (used for acid reflux)

Diuretics (medicines used to treat oedema, high blood pressure) Ex. furosemide, hydrochlorothiazide, indapamide

Clarithromycin, josamycin, telithromycin,erythromycin (medicines used for bacterial infections)

Nelfinavir, ritonavir (medicines used to treat HIV infections)

Nefazodone (medicine used to treat depression)

Diltiazem, verapamil (medicines used to treat high blood pressure/angina pectoris)
B.Drug -Food interaction:
Avoid drinkingrapefruit juice while taking IVASAFE 5 TABLET as it may alter the effect of the medicine.
Overdosage:
If you or anyone else accidentally take too much of IVASAFE 5 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are breathlessness and tiredness.
SYNOPSIS

Drug :?? Ivabradine

Pharmacological Category :?? Hyperpolarization-activated cyclic nucleotide-gated channel blockers?

Therapeutic Indication :?? Symptomatic stable angina, Chronic Heart failure???????

Dosage Forms :?? Tablet

MORE INFORMATION

Keep IVASAFE 5 TABLET out of the sight and reach of children

Store at room temperature

FAQs ABOUT IVASAFE 5 TABLET
What is IVASAFE 5 TABLET used for?
IVASAFE 5 TABLET is used to treat symptomatic stable angina pectoris (chest pain) in adult patients who are intolerant/incapable to take heart medicines (such as beta blockers) which is also used to treat chronic heart failure in adult patients whose heart rate is over/equal to 75 beats per minute.
How IVASAFE 5 TABLET works?
IVASAFE 5 TABLET works by reducing the heart rate which leads to low oxygen requirement of the heart resulting in improved blood supply throughout the body (with each hear beat) thus providing relief from angina pectoris and preventing the occurrence of chronic heart failure in affected individuals.
What are the most common side effects of taking IVASAFE 5 TABLET?
The most common side effects of taking IVASAFE 5 TABLET are brief moments of increased brightness (due to sudden changes in light intensity), slow heart rate, uncontrolled blood pressure, headache, dizziness, and/or blurred vision. Consult your doctor if any of these symptoms worsen.
How to take IVASAFE 5 TABLET?
Take IVASAFE 5 TABLET as advised by your physician. Swallow the medicine with alass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
CanIVASAFE 5 TABLET be used in pregnant women?
No, IVASAFE 5 TABLET is not recommended for use during pregnancy and in women planning for pregnancy as it may cause harm to the foetus. Women of childbearing potential should use reliable contraceptives while on treatment with IVASAFE 5 TABLET. Consult your doctor before taking the medicine.
REFERENCES
1. K.D.Tripathi. Antianginal and Other Anti-ischaemic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page ? 554.
2. Mirembe Reed;?Connor C. Kerndt;?Diala Nicolas. Ivabradine. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. [Revised in May 2022] [Accessed on 14th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK507783/
3. Lupin Limited. IVABRAD OD 10MG, IVABRAD OD 15MG. [Accessed on 14th May 2022] https://www.lupin.com/our-products/product-finder/?searchkey=Ivabradine
4. Alniche Life Sciences Pvt. Ltd. Ivaniche. [Accessed on 14th May 2022] https://www.alniche.com/cardiac-diabetes-care/
5. Noucor Health S.A. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 14th May 2022] https://www.medicines.org.uk/emc/files/pil.9104.pdf
USEFUL DIAGNOSTIC TESTS

Electrocardiogram

Stress test

Coronary angiography

VIDEOS

Ivabradine Tablet ? Drug Information
Ivabradine Tablet : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
PRODUCT DETAILS

Net Qty

1 N

Item Weight

17.5

Ingredient

IVABRADINE 5 mg

Hsn Code

30049099

Additional information

Weight
17.5 g

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