Lariam, also known as Mefloquine is an anti-malaria tablet that can be taken to prevent malaria infections when visiting high-risk countries. Malaria is caused by several parasites of the Plasmodium family and is spread through the bite of an infected mosquito.? Mefloquine can be used to prevent an infection from one or more of these parasites.Malaria is typically found in and around the tropics and this includes the regions of South America, parts of Asia, and sub-Saharan Africa.The burden of malaria is greatest in Africa, but recent developments give hope to the populations who live with this disease.