Leflunomide film-coated tablets are a pharmaceutical formulation of the medication leflunomide. These tablets are used primarily in the treatment of rheumatoid arthritis (RA) and certain other autoimmune conditions.
Here are some key points about Leflunomide film-coated tablets:
Mechanism of Action: Leflunomide works by inhibiting an enzyme called dihydroorotate dehydrogenase, which is involved in the production of DNA and RNA in immune cells. By interfering with this process, Leflunomide reduces the activity of the immune system, which helps to alleviate symptoms of autoimmune diseases like RA.
Indications: Leflunomide film-coated tablets are primarily used in the treatment of rheumatoid arthritis. They may also be prescribed for other autoimmune conditions such as psoriatic arthritis and systemic lupus erythematosus (SLE) in some cases.
Dosage: The dosage of Leflunomide can vary depending on the individual?s condition and response to treatment. However, the typical starting dose for rheumatoid arthritis is often 20mg once daily. The tablets are usually administered orally with or without food.
Side Effects: Common side effects of Leflunomide may include diarrhea, nausea, hair loss, elevated liver enzymes, and respiratory infections. It may also cause a decrease in white blood cell count or affect blood pressure. Serious but rare side effects may include liver toxicity, interstitial lung disease, and peripheral neuropathy.
Precautions: Leflunomide is not recommended during pregnancy due to potential risks to the fetus. Women of childbearing age are typically advised to use reliable contraception during treatment with Leflunomide and undergo a washout procedure to eliminate the drug from their system before attempting to conceive. It?s important to discuss any other medications or supplements being taken with a healthcare provider, as certain combinations may increase the risk of side effects or drug interactions.
Patients should follow their healthcare provider?s instructions carefully regarding the use of Leflunomide film-coated tablets and report any unexpected or severe side effects promptly. Regular monitoring of liver function and blood cell counts may be necessary during treatment.