Folate, homocysteine & cardiovascular health Folate helps maintain healthy homocysteine levels already within the normal range. By helping to inhibit excess homocysteine, folate supports healthy levels of this important cardiovascular health biomarker. 5-MTHF, homocysteine & cognitive health Since people with elevated homocysteine levels have a greater risk of cognitive decline, getting enough folate is especially crucial for aging individuals attempting to maintain cognitive health. Take alone or with B12 for enhanced effect The RDA for folate for non-pregnant or lactating adults is 400 mcg a day. This formula delivers 1,700 mcg of 5-MTHF folate. If you?re looking for a higher dose, try our High Potency Optimized Folate formula, which delivers 8,500 mcg of 5-MTHF. You can combine either formula with vitamin B12 in the form of methylcobalamin, vitamin B6 in either the pyridoxal 5?-phosphate or pyridoxine hydrochloride form, and/or riboflavin.