Marevan 5mg Tablets (Warfarin Sodium) is an anticoagulant which is used to prevent the blood from clotting. You should inform the doctor if you have any bleeding disorder before taking this medicine and you should be aware of the possible side effects of this medicine. Close monitoring of liver and kidney function is necessary while receiving this medicine due to an increase in the risk of bleeding.
Side effects
Major & minor side effects for Marevan 5mg Tablets (Warfarin Sodium)

Abdominal pain severe

Blurred vision severe

Blood in urine and stools severe

Headache severe

Dizziness severe

Diarrhea severe

Skin rash and itching severe

Yellow colored eyes or skin severe

Muscle or joint pain

Excessive air or gas in stomach

Hair loss or thinning of the hair

Uses of Marevan 5mg Tablets (Warfarin Sodium)
What is it prescribed for?

Deep Vein Thrombosis
Marevan 5mg Tablets (Warfarin Sodium) is used to prevent the blood clot formation in legs and other extremities.

Pulmonary Embolism
Marevan 5mg Tablets (Warfarin Sodium) is used in the treatment of Pulmonary embolism (blood clot in the lung) by improving the blood flow in the lungs.

Prophylaxis for Myocardial Infarction
Marevan 5mg Tablets (Warfarin Sodium) is used to prevent the formation of clots in vessels that supply blood to the heart. This helps in preventing a heart attack.

Prevention of Thromboembolism in Atrial Fibrillation
Marevan 5mg Tablets (Warfarin Sodium) is used to prevent blood clot formation in patients with heart disorders like atrial fibrillation (irregular heartbeat).

Concerns

Frequently asked questions

Onset of action
The effect of this medicine can be observed in 36 to 48 hours.

Duration of Effect
The effect of this medicine lasts for an average duration of 2 to 5 days.

Safe with Alchohol?
Alcohol consumption is not recommended in patients receiving Marevan 5mg Tablets (Warfarin Sodium) due to an increase in the risk of bleeding. Close monitoring of prothrombin time and symptoms like excessive bleeding is necessary if alcohol is consumed with Marevan 5mg Tablets (Warfarin Sodium) .

Is it habit forming?
No habit forming tendency has been reported.

Usage in pregnancy?
This medicine is not recommended for use in pregnant women except in life-threatening conditions where the potential benefits outweigh the risks. Discuss all the risks and benefits with your doctor before taking this medicine.

Usage while breast-feeding?
This medicine is recommended for use in breastfeeding women only if clearly needed. The risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, close monitoring of the infant for any undesired effects is necessary.

When not to use?

Allergy
This medicine is not recommended for use in patients with a known allergy to Marevan 5mg Tablets (Warfarin Sodium) .

Central nervous system bleeding
This medicine is not recommended for use in patients with a head and/or spinal cord injury.

Bleeding disorder
This medicine is not recommended for use in patients who have a known history of bleeding disorders or an active bleeding disorder (inability of the blood to clot normally).

Gastrointestinal disorders
This medicine is not recommended for use in patients with a known history of gastrointestinal disorders like peptic ulcer disease or gastrointestinal bleeding due to an increase in the risk of further bleeding.

Warnings

Warnings for special population

Pregnancy
This medicine is not recommended for use in pregnant women except in life-threatening conditions where the potential benefits outweigh the risks. Discuss all the risks and benefits with your doctor before taking this medicine.

Breast-feeding
This medicine is recommended for use in breastfeeding women only if clearly needed. The risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, close monitoring of the infant for any undesired effects is necessary.

General Warnings

Bleeding
Marevan 5mg Tablets (Warfarin Sodium) is known to cause severe bleeding. It is not recommended in patients with conditions like gastrointestinal bleeding, head injury, and patients about to undergo a surgery. Any symptoms of blood in the stools, vomiting blood, or blood in the urine should be reported to the doctor on priority. Close monitoring of prothrombin time is necessary while receiving this medicine.

Tissue Necrosis
Marevan 5mg Tablets (Warfarin Sodium) may cause tissue death within a few days of the treatment. Close monitoring of symptoms like pain and change in skin color is necessary while receiving this medicine. It is advised to stop the treatment if these symptoms appear. An alternate treatment option should be considered based on the clinical condition.

Calciphylaxis
Marevan 5mg Tablets (Warfarin Sodium) may cause a rare reaction called Calciphylaxis in which calcium is accumulated in small blood vessels of the fat and skin tissues. Close monitoring of symptoms like pain and change in skin color is necessary while receiving this medicine. It is advised to stop the treatment if these symptoms appear. An alternate treatment option should be considered based on the clinical condition.

Dosage

Missed Dose
Take the missed dose as soon as you remember. If it is almost the time for your next scheduled dose, then the missed dose should be skipped.

Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions
Interaction with Medicines

Ethinyl Estradiol moderate

Aspirin severe

Proton pump inhibitors moderate

Fluoroquinolone antibiotics severe

Disease interactions

severe
Marevan 5mg Tablets (Warfarin Sodium) is not recommended in patients with a history of bleeding disorders or an active bleeding disorder (inability of the blood to clot normally) due to an increase in the risk of further bleeding. Replacement with a suitable alternative should be done under your doctor’s supervision.

severe
Marevan 5mg Tablets (Warfarin Sodium) is not recommended in patients with a liver injury/disease due to an increase in the risk of bleeding. Close monitoring of liver function and symptoms like blood in the urine and stools, dizziness, unusual bleeding, etc. is necessary while receiving this medicine.

General Instructions

Take Marevan 5mg Tablets (Warfarin Sodium) as advised by the doctor. Do not consume larger quantities than prescribed. This medicine is not recommended in patients with gastrointestinal bleeding, head injury, and low blood platelets level. Patients with liver injury/disease are advised to consult the doctor before taking this medicine.

Other details

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

References

medlineplus.gov –
Warfarin [Internet].
Available from: https://medlineplus.gov/druginfo/meds/a682277.html
[cited 7/7/2020].
2020