Nitril Spray 0.4 mg/Dose 200 Doses

Nitril Spray 0.4 mg/Dose 200 Doses works by relaxing the blood vessels and by reducing the workload on the heart.
Side effects
Major & minor side effects for Nitril Spray 0.4 mg/Dose 200 Doses

Difficulty in breathing severe

Dizziness and fainting severe

Swelling of the eyes, ears, and inside of nose severe

Nausea and Vomiting

Headache

Coma severe

Seizures severe

Change in heart rate severe

Excessive sweating

Flushing

Severe chest pain severe

Blurred vision

Pale and clammy skin

Uses of Nitril Spray 0.4 mg/Dose 200 Doses
What is it prescribed for?

Angina pectoris
This medicine is used for the prevention and treatment of chest pain caused due to reduced blood and oxygen flow to the heart. Angina may be stable (happens after exertion and is short lasting) or unstable (happens in an unpredicted manner and is more severe and long lasting)

Hypertension during surgeries
This medicine is used to control increased blood pressure while a major surgical procedure is performed on a patient.

Chronic anal fissures
This medicine is also used rectally to relieve pain caused due to anal fissures or tears on the wall of the rectum.

Concerns

Frequently asked questions

Onset of action
The effect of this medicine can be observed within an hour of oral administration. However, this time is subject to vary depending on the route of administration. The effect of this medicine can be observed within minutes of intravenous administration and takes about 30-60 when administered topically.

Duration of Effect
The effect of this medicine lasts for an average duration of 12 hours upon oral administration. This time duration is subject to variations depending on the route of administration.

Safe with Alchohol?
Avoid the use of alcohol while taking this medicine.

Is it habit forming?
No habit forming tendencies were reported.

Usage in pregnancy?
The use of this medicine by pregnant women is not recommended unless necessary and the benefits outweigh the risks involved with use. Consult your doctor before using this medicine.

Usage while breast-feeding?
The use of this medicine is not recommended by breastfeeding women unless necessary. Consult your doctor before using this medicine.

When not to use?

Allergy
This medicine is not recommended for use if you have a known history of allergy to or any nitrate-containing medicines.

Anemia
This medicine is not recommended for use if you have anemia or low levels of hemoglobin in the blood.

Glaucoma
This medicine is not recommended for use if you have an eye condition called closed angle glaucoma.

Obstructive heart disease
This medicine is not recommended for use if you have a condition where the blood vessels in the heart have blockage due to swelling or narrowing.

Head trauma/ Increased intracranial pressure
This medicine is not recommended for use in patients having a severe head injury or the pressure in the brain is elevated.

Medicine for erectile dysfunction
This medicine is not recommended for use if you are taking medicines for the treatment of erectile dysfunction. One of the most commonly used medicines for this condition is viagra (sildenafil),

Heparin
This medicine is not recommended for use if you are being given Heparin for correcting any blood clotting disorder.

Warnings

Warnings for special population

Pregnancy
The use of this medicine by pregnant women is not recommended unless necessary and the benefits outweigh the risks involved with use. Consult your doctor before using this medicine.

Breast-feeding
The use of this medicine is not recommended by breastfeeding women unless necessary. Consult your doctor before using this medicine.

General Warnings

Other diseaes
Report the incidence of all other diseases of the heart, lung, thyroid, kidney, liver etc to the doctor before receiving this medicine. All these conditions should be taken into consideration to ensure safe and effective use of this medicine.

Fall in blood pressure
Use of this medicine can cause a fall in blood pressure in general and may make you feel dizzy especially while getting up from lying or sitting position (Postural hypotension).

Drowsiness
Use of this medicine can cause drowsiness and affect the ability to drive or operate heavy machinery. Refrain from performing tasks that require a high level of mental alertness after taking this medicine.

Withdrawal symptoms
Use of this medicine should not be stopped abruptly as the patient is likely to experience some discomfort.

Chest pain due to other reasons
Use of this medicine to treat chest pain associated with other causes like Hypertrophic Cardiomyopathy (enlarged heart muscles) is not recommended. The pain may worsen if this medicine is used.

Nitrate free interval
The likelihood of development of drug tolerance is very high if this medicine is taken very regularly. A minimal amount of nitrate free time to avoid tolerance is 10-12 hr/day. The tolerance developed is in general for nitrates and may affect other medicines containing nitrates (cross-tolerance).

Methemoglobinemia
Use of this medicine may affect the red blood cells and cause changes in the hemoglobin resulting in blue colored skin, headache, fatigue, lack of energy etc. Use of this medicine should be discontinued if any such signs and symptoms are experienced.

Form and route of administration
This medicine is available in many forms which can be administered via different routes. You are advised to not change the form and route of administration without consulting a doctor

Allergy to other components
Other components present along with different forms of this medicine may potentially cause an allergic reaction or adverse effects in some people. The intravenous form may contain dextrose and should be carefully administered in diabetics. Similarly, the oral form may contain lactose and may cause an allergic reaction in lactose intolerant people.

Dosage

Missed Dose
Contact your doctor immediately if you miss a scheduled dose of this medicine.

Overdose
Contact your doctor immediately if an overdose with this medicine is suspected. Symptoms of an overdose may include headache, confusion, fever, change in the heart beat, nausea, vomiting etc.

Interactions
Interaction with Medicines

Amitriptyline moderate

Amlodipine severe

Prilocaine severe

Sildenafil severe

Riociguat severe

Dihydroergotamine moderate

Heparin moderate

Disease interactions

severe
This medicine should be used with extreme caution in patients suffering from a heart attack or heart failure. The use should be preceded by suitable clinical examinations to ensure safe and effective use.

severe
This medicine should be used with caution in patients suffering from anemia as the risk of adverse effects are significantly high. Appropriate dose adjustment and safety monitoring must be done in such cases.

severe
This medicine should be used with extreme caution in patients who have low blood pressure. The risk of further lowering of blood pressure and associated adverse effects are significantly high.

General Instructions

Take Nitril Spray 0.4 mg/Dose 200 Doses as instructed by the doctor. The dosage form and route of administration prescribed are specific to your conditions and all related instructions should be followed while using this medicine.

Other details

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

References

practo.com –
Glyceryl Trinitrate [Internet].
Available from: https://www.practo.com/medicine-info/glyceryl-trinitrate-133-api
[cited 30 september 2019].
16 Nov 2017

dailymed.nlm.nih.gov –
Glyceryl Trinitrate [Internet].
Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c555f8de-477f-0225-98a2-baf8945bbd63
[cited 30 september 2019].
February 10, 2017

medlineplus.gov –
Glyceryl Trinitrate [Internet].
Available from: https://medlineplus.gov/druginfo/meds/a682346.html
[cited 30 september 2019].
11 September 2019