Ocifril 50mg Tablet 10?S Allschoolabs -

Description

INTRODUCTION
OCIFRIL contains Clomipramine which belongs to the group of medicines called Antidepressants. It is used to depression, obsessive compulsive disorder (OCD), phobias (fear) and collapse (cataplexy) associated with narcolepsy (a sleep disorder).
Before taking OCIFRIL inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have low blood pressure, problems in adrenal gland or thyroid gland, brain injury, history of fits, or any other mental illnesses apart from depression and OCD (such as mania, schizophrenia, anxiety etc).
OCIFRIL is not recommended for use in pregnant or breastfeeding women unless considered necessary by the physician. Avoid drinking grapefruit juice or cranberry juice while taking OCIFRIL as it may increase the risk of side effects.
The most common side effects of taking OCIFRIL are headache, dizziness, tiredness, nausea, vomiting, stomach upset, dry mouth, constipation, diarrhea, increased sweating, low sex drive, inability to maintain an erection, muscle twitching and problems in sleeping. Consult your doctor if any of these side effect worsens.
You must also inform your doctor if you experience any unusual behaviours (such as anxiety, panic attacks, difficulty in sleeping, irritability, restlessness) or worsening of depression, suicidal thoughts or behaviour after taking OCIFRIL.
USES OF OCIFRIL
It is used to treat:
Depression

Obsessive Compulsive Disorder (OCD)

Fear (phobias)

Cataplexy (collapse associated with narcolepsy)

HOW OCIFRIL WORKS
OCIFRIL is a tricyclic antidepressant. It works by increasing the levels of certain chemicals within the brain (such as serotonin and norepinephrine) that controls mood and mental health. As a result, it elevates mood and makes you feel active and energetic. It also reduces unwanted obsessive thoughts or fears and stops the attacks of cataplexy and sleep paralysis.
DIRECTIONS FOR USE
Take OCIFRIL as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Do not stop taking OCIFRIL without consulting your doctor as it may lead to withdrawal symptoms such as nausea, vomiting, stomach pain, diarrhoea, lack of sleep, headache, nervousness and/or anxiety.
SIDE EFFECTS OF OCIFRIL

COMMON

Headache, dizziness, tiredness, sleepiness

Nausea, vomiting, stomach upset

Increased hunger, weight gain

Dry mouth, constipation, diarrhea

Increased sweating, fast heart rate

Feeling lightheaded while standing up

Feeling shaky, restless or anxious

Low sex drive, inability to maintain an erection

Muscle twitching

Increase in blood sugar levels

Changes in the amount of urine produced

Speech problems

Problems in sleeping, nightmares

Feeling sad or depressed, memory problems

Breast enlargement and milk flow

Numbness or tingling in the arms and legs

Ringing in the ears (tinnitus)

UNCOMMON

Clumsiness and lack of coordination

RARE

Vaginal bleeding
Stop taking OCIFRIL and contact your doctor immediately if you experience any of the following side effects:
Signs of serotonin syndrome (feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles, or muscle twitching, loss of coordination, nausea, vomiting, diarrhea or seizures)

Worsening of depression, suicidal thoughts or behavior

Behavioural changes (such as feeling excited anxiety, panic attacks, difficulty in sleeping, irritability, hallucinations, restlessness)

Difficulty in passing urine

Signs of allergic reactions (such as skin rash, swelling of the hands, face, tongue, neck or throat, increased fluid in tissues, fast heart rate, difficulty in breathing)

Signs of Neuroleptic malignant syndrome (such as high fever, rigid muscles, mood swings, fast or irregular heartbeat, changes in blood pressure, increased sweating)

Increased infections, fever, chills, sore throat, mouth ulcers

Signs of liver problems (such as nausea, vomiting, generally feel unwell, loss of appetite, fever, yellowing of the skin or whites of the eyes, light coloured stools and dark-coloured urine)

Signs of low blood potassium levels (such as shortness of breath, irregular heartbeat and fainting)

Low blood sodium levels (causing headache, nausea, difficulty in concentration, memory impairment, confusion, feeling weak or unsteady, hallucinations, fainting or seizures)

Sever muscle pain and damage

HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating rich or spicy food. Contact your doctor if nausea worsens.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise regularly. Contact your doctor if constipation persists.
Diarrhoea:
Drink fluids, such as water or fruit juice in enough quantity to keep yourself hydrated. Don?t take any medicine on your own for treating diarrhoea without talking to your doctor. Contact your doctor if diarrhoea worsen.
Loss of appetite:
Eat when you are hungry. Have smaller meals more often than usual. Snack only when you?re hungry. Eat a nutritious snack which is rich in calories and protein, such as dry fruit and nuts. Contact your doctor if your appetite did not improve.
Headache:
Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving balm on the head if needed. Do not consume alcohol. Contact your doctor if your headache did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate machinery if you feel dizzy. Avoid alcohol consumption as it aggravates dizziness. Contact your doctor if dizziness worsens.
WARNING & PRECAUTIONS

PREGNANCY
OCIFRIL is not recommended for use in pregnant women, unless considered necessary by the physician. Therefore, inform your doctor before taking OCIFRIL if you are pregnant or planning to become pregnant.
BREASTFEEDING
OCIFRIL is not recommended for use in breast feeding women as it may pass through the breast milk. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
OCIFRIL may impair your ability to drive or handle heavy tools. Therefore, avoid driving or handling any heavy tools or machines as a precaution.
ALCOHOL
Avoid consumption of alcohol while taking OCIFRIL as it may increase the risk of side effects.
KIDNEY
OCIFRIL should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.
LIVER
OCIFRIL is not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
ALLERGY
Do not take OCIFRIL if you are allergic to Clomipramine or to any other tricyclic antidepressants (such as imipramine, amitriptyline).
HEART DISEASE
OCIFRIL is not recommended for use in patients with heart problems (including a recent heart attack). It should be used with caution in patients with irregular heartbeat. Therefore, consult your doctor before taking it.
OTHERS
OCIFRIL is not recommended for use if you:
Suffer from mania (mood disorder that causes high levels of excitement)

Have narrow-angle glaucoma (increased eye pressure)

Have difficulty in passing urine
Before taking OCIFRIL inform your doctor if you:
Suffer from epilepsy (fits)

Have brain injury or any damage in the brain

Have hypokalaemia (low potassium levels in the blood)

Have any blood disorders

Have low blood pressure

Want to undergo electric shock therapy (ECT)

Suffer from schizophrenia or other mental illnesses (such as anxiety)

Have an overactive thyroid gland

Have severe constipation for a long time

Have phaeochromocytoma or neuroblastoma (tumour of the adrenal gland)

Wear contact lenses

Previously had suicidal thoughts

Are going to have any surgery (including dental procedures)
Use in Paediatrics:
OCIFRIL is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before taking it.
Use in Geriatrics:
OCIFRIL should be used with caution in elderly patients. Therefore, consult your doctor before taking it. Proper dose adjustments and careful monitoring are required in such patients.
INTERACTIONS
A. Drug-Drug Interactions:
Before taking OCIFRIL inform your doctor if you are taking any of the following medicines such as:
Other medicines used to treat depression such as MAOIs (Ex. tranylcypromine, phenelzine, moclobemide), SSRIs (Ex. fluoxetine, fluvoxamine, paroxetine, sertraline), SNRIs (Ex. venlafaxine), tricyclic and tetracyclic antidepressants (Ex. amitriptyline, dothiepin, maprotiline), St. John?s Wort

Diuretics (medicines used to increase urine output) such as furosemide

Anaesthetics (medicines used for the temporary loss of bodily sensation) Ex. lidocaine, sevoflurane

Antihistamines (used to treat allergies) Ex. cetirizine and terfenadine

Medicines used to treat anxiety and other psychiatric disorders (Ex. thioridazine, lithium, clozapine, pimozide, haloperidol, buspirone, diazepam and alprazolam)

Medicines used to treat high blood pressure and other heart problems (such as guanethidine, betanidine, reserpine, clonidine, alpha methyldopa, norepinephrine noradrenaline, disopyramide, flecainide, procainamide, epinephrine, isoprenaline, digoxin, amiodarone, quinidine, diltiazem, verapamil, atenolol, sotalol)

Anticoagulants (medicines used to treat blood clots) such as warfarin

Medicines used to treat Parkinson?s disease (Ex. levodopa, biperiden, entacapone or selegiline)

Nicotine (a medicine used to quit smoking)

Medicines used to prevent seizures or fits (Ex. phenytoin, carbamazepine)

Medicines used to treat colds and flu (such as ephedrine, phenylephrine or phenylpropanolamine)

Methylphenidate (a medicine used to treat ADHD)

Rifampicin (a medicine used to treat tuberculosis)

Quinine (a medicine used to treat malaria)

Medicines used to treat pain (such as tramadol, fentanyl, nefopam, morphine or morphine related substances like codeine, dihydrocodeine, buprenorphine)

Contraceptive pills (Ex. levonorgestrel, ethinylestradiol)

Colestipol, cholestyramine (medicines used to treat high cholesterol levels)

Medicines used to treat viral infections (Ex. ritonavir, indinavir)

Terbinafine (used to treat fungal infections)

Disulfiram (a medicine helps to quit alcohol consumption)

Altretamine (a medicine used to treat cancer)

Baclofen (a medicine used to treat muscle spasms)

Levacetylmethadol (used to treat addiction to opioid drugs such as heroin)

Linezolid (used to treat bacterial infections)

Intravenous methylene blue (a medicine used to treat methemoglobinemia)

Triptans Ex. sumatriptan (medicine used for migraine)

Tryptophan (an amino acid that can induce sleep)
B. Drug-Food Interactions:
Avoid eating grapefruit or drinking grapefruit juice or cranberry juice while taking OCIFRIL as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally took more OCIFRIL, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include drowsiness, stupor (unable to move but still conscious), uncoordinated muscle movement, restlessness, enhanced reflexes, muscle stiffness, irregular muscle contractions, writhing movements of the hands and feet, fits, high or low blood pressure, high fever, rapid or irregular heartbeat, sudden chest pain (angina), abnormally dilated pupil, shortness of breath, blue skin and a decrease or absence of urine production.
SYNOPSIS

Drug :?? Clomipramine

Pharmacological Category :?? Tricyclic antidepressants

Therapeutic Indication :?? Depression, obsessive compulsive disorder, phobias, Cataplexy? ? ? ? ?

Dosage Forms :?? Tablet,?Capsule

MORE INFORMATION

Keep OCIFRIL out of sight and reach of children

Store OCIFRIL below 25?C

FAQs ABOUT OCIFRIL
What is the use of OCIFRIL?
OCIFRIL is used to depression, obsessive compulsive disorder (OCD), phobias (fear) and collapse (cataplexy) associated with narcolepsy (a sleep disorder).
How long does it take for OCIFRIL to work?
It may take several weeks for OCIFRIL to heal your condition. Therefore, continue to take OCIFRIL for the stipulated duration recommended by your doctor without any interruption.
Is OCIFRIL a strong antidepressant?
Yes. OCIFRIL is a strong antidepressant that effectively controls signs of depression. It works by increasing the levels of certain chemicals (serotonin and noreipherine) within the brain that stabilizes mental health.
What is the best time to take OCIFRIL?
Take OCIFRIL approximately at the same time each day. You can take OCIFRIL either in the morning or in the evening as per doctor?s instructions. Taking it at the same time each day will have the best effect and it would also help you remember your daily dose.
Can OCIFRIL be used to reduce anxiety?
OCIFRIL is a prescription medicine used to treat depression. It has been shown to reduce anxiety. However, there are no proper evidence to prove that. If you wish to control anxiety using OCIFRIL, speak with your doctor for advice.
How does OCIFRIL works?
OCIFRIL works by increasing the levels of certain chemicals within the brain (such as serotonin and norepinephrine) that controls mood and mental health. As a result, it elevates mood and makes you feel active and energetic. It also reduces unwanted obsessive thoughts or fears and stops the attacks of cataplexy and sleep paralysis.
Can OCIFRIL cause weight gain?
Yes. Weight gain is one of the common side effects of taking OCIFRIL. If this side effect bothers you, contact your doctor.
Will OCIFRIL reduce my sex drive?
Yes. OCIFRIL may affect your sexual life. It may decrease sex drive or cause problems in orgasm, ejaculation or erection. Therefore, consult your doctor if you experience any such symptoms.
Will the use of OCIFRIL make you feel sleepy or tired?
Yes, OCIFRIL can make your feel sleepy, drowsy, or tired. Do not drive or handle heavy machines or tool if you feel drowsy or sleepy. Avoid consumption of alcohol as it can aggravate your drowsiness.
Can OCIFRIL be used in children?
OCIFRIL is generally not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.
What to do if I forget to take a dose of OCIFRIL?
If you forget to take a dose of OCIFRIL, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of OCIFRIL to compensate a missed dose, as it could lead to toxicity.
Will taking a higher dose of OCIFRIL than the prescribed one be beneficial?
No, taking a higher dose of OCIFRIL will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Can I stop taking OCIFRIL once my symptoms subside?
No. Do not stop taking OCIFRIL without consulting your doctor even if you feel better during the mid-way of the therapy. You may feel better after 2 weeks of therapy with OCIFRIL, but it might take several weeks for you to experience complete benefits. Also, sudden discontinuation of therapy may cause withdrawal symptoms such as nausea, vomiting, stomach pain, diarrhoea, lack of sleep, headache, nervousness and/or anxiety.
Can OCIFRIL be taken daily?
Yes. OCIFRIL can be taken daily as per your doctor?s instruction. However, if you are doubtful, consult your doctor.
Can OCIFRIL be used in pregnant women?
OCIFRIL is not recommended for use in pregnant women as it may harm the growing fetus. Therefore, consult your doctor before receiving it.
REFERENCES
1. KD. Tripathi. Antidepressant and Antianxiety Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page 455, 458.
2. Marcia Wilson, Jayson Tripp. Clomipramine. Stat pearls. NIH. National Library of Medicine. National Center for Biotechnology Information. May 2022. [Accessed on 18th November 2022]?https://www.ncbi.nlm.nih.gov/books/NBK541006/
3.?Clomipramine in the treatment of patients with obsessive-compulsive disorder. The Clomipramine Collaborative Study Group. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. August 1991. [Accessed on 18th November 2022]?https://pubmed.ncbi.nlm.nih.gov/1883256/
4. Generics UK. Limited. Electronic Medicines Compendium. [Revised in November 2020] [Accessed on 18th November 2022]?https://www.medicines.org.uk/emc/files/pil.2550.pdf
5. Teva Pharmaceuticals. Hungary. Clomipramine. [Revised in October 2021] [Accessed on 18th November 2022]?https://products.tevauk.com/mediafile/id/51807.pdf
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