Origus 50mg Capsule 10?S Allschoolabs -

Specification

Origus 50mg Capsule 10?S

?Diacerein 50 mg

ORIGUS 50MG CAPSULE contains Diacerein which belongs to the group of medicines called Anthraquinones. It is used for the symptomatic treatment of functional symptoms of osteoarthritis.
Osteoarthritis is a common progressive disorder affecting primarily weight bearing joints (knee, hip), characterised by progressive destruction of cartilage causing pain, limitation of motion, stiffness, deformity and disability.
Prior to the treatment, your doctor may want you to take several blood tests to understand your existing condition like liver disease.
Avoid taking alcohol with ORIGUS 50MG CAPSULE as it may increase the risk of liver damage. ORIGUS 50MG CAPSULE is not recommended for use in patients having liver or kidney disease, colitis or crohn?s disease, partial or complete intestinal obstruction or abdominal pain with an unknown cause.
Inform your doctor, if you have kidney or urinary problems, history of diarrhea, irritable bowel disease, rare hereditary diseases such as congenital galactosemia, glucose or galactose malabsorption syndrome or lactase deficiency.
ORIGUS 50MG CAPSULE is not recommended for use in pregnant and breastfeeding women. Contact your doctor before taking.
ORIGUS 50MG CAPSULE is not recommended for use in children and adolescents under 15 years of age. Contact your doctor before taking.
ORIGUS 50MG CAPSULE should be used with caution in elderly aged above 65 years. Contact your doctor before taking.
The most common side effects of taking ORIGUS 50MG CAPSULE are diarrhea, soft stools, pain in abdomen, frequent bowel movements, flatulence, skin rash, itching, and eczema. Contact your doctor if any of the side effects worsen.
USES OF ORIGUS 50MG CAPSULE

Used for the symptomatic treatment of Osteoarthritis

HOW ORIGUS 50MG CAPSULE WORKS
ORIGUS 50MG CAPSULE works by blocking the chemicals (interleukin-1) causing inflammation and destruction of cartilage in the body. It also stimulates the production of certain chemicals called transforming growth factor-? (TGF-?) which triggers chondrocyte proliferation and stimulates the production of collagen and proteoglycan, glycosaminoglycans and hyaluronic acid. Therefore ORIGUS 50MG CAPSULE prevents the cartilage destruction and improves symptoms in patients with osteoarthritis.
DIRECTIONS FOR USE
Take ORIGUS 50MG CAPSULE as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF ORIGUS 50MG CAPSULE

COMMON

Diarrhea

Soft stools

Pain in abdomen

Frequent bowel movements

Flatulence

Skin rash, itching, eczema

UNCOMMON

Increased liver enzymes

RARE

Pigmentation of colorectal mucosa (melanosis coli)
Stop taking ORIGUS 50MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:
Diarrhea (risk of dehydration and hypokalemia)

Signs of liver disease such as increased liver enzyme, tiredness, and loss of appetite, jaundice (yellowish discoloration of skin and white of eyes), abdominal pain, nausea, vomiting, change in stool and urine colour, reduced consciousness, itchy skin

HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for treating diarrhea. Contact your doctor if the symptom did not improve.
Stomach pain:
Rest and relax. Try to have smaller meals but take frequently. Keep a heat pad on your stomach. Do not self-treat and contact your doctor if the symptom did not improve.
Flatulence:
Eat smaller meals but take frequently and exercise regularly. If the symptom does not improve, contact your doctor.
Itchy skin:
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use unscented moisturizers to soothe and hydrate the affected area. If the symptom does not improve, contact your doctor.
WARNING & PRECAUTIONS

PREGNANCY
ORIGUS 50MG CAPSULE is generally not recommended for use in pregnant women. Consult your doctor before taking.
BREASTFEEDING
ORIGUS 50MG CAPSULE is generally not recommended for use in breastfeeding women as it is not known if this medicine passes into breast milk. Consult your doctor before taking.
ALCOHOL
Avoid consumption of alcohol while taking ORIGUS 50MG CAPSULE as it increases the risk of liver damage.
KIDNEY
ORIGUS 50MG CAPSULE is not recommended for use in patients with severe kidney disease. Consult your doctor before taking.
LIVER
ORIGUS 50MG CAPSULE is not recommended for use in patients with liver disease. Consult your doctor before taking.
ALLERGY
Do not take ORIGUS 50MG CAPSULE if you are allergic to Diacerein or any of the other ingredients of this medicine.
OTHERS
ORIGUS 50MG CAPSULE is not recommended for use if you have:
Colitis or crohn?s disease

Partial or complete intestinal obstruction

Abdominal pain with an unknown cause

Rapidly progressive (worsening) hip osteoarthritis
Before taking ORIGUS 50MG CAPSULE, inform your doctor if you have:
Urinary system problems

Irritable bowel disease

Rare hereditary diseases such as congenital galactosemia, glucose or galactose malabsorption syndrome or lactase deficiency
Use in pediatrics:
ORIGUS 50MG CAPSULE is generally not recommended for use in children and adolescents under 15 years of age. Consult your doctor before taking.
Use in geriatrics:
ORIGUS 50MG CAPSULE is not recommended for use in elderly patients aged above 65 years. Consult your doctor before taking.
INTERACTIONS
A. Drug ? Drug interactions:
Before taking ORIGUS 50MG CAPSULE, inform your doctor if you are taking any of the following medicine:
Laxatives (medicines used to treat constipation)

Antacids (Ex. Aluminium hydroxide, magnesium hydroxide or calcium hydroxide) (medicines used to treat acidity)

Diuretics (medicines used for hypertension)

Digoxin, digitoxin (medicines used for heart failure)

Amoxicillin/clavulanic acid (medicines used for infections)

Chemotherapy (medicines used to treat cancer)
Overdosage:
If you or anyone else accidentally takes too much of ORIGUS 50MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are diarrhea.
SYNOPSIS

Drug :?? Diacerein

Pharmacological Category :?? Anthraquinones

Therapeutic Indication :?? Osteoarthritis

Dosage Forms :?? Tablet, Capsule

MORE INFORMATION

Keep ORIGUS 50MG CAPSULE out of the sight and reach of children

Store ORIGUS 50MG CAPSULE below 25?C

FAQs ABOUT ORIGUS 50MG CAPSULE
Is ORIGUS 50MG CAPSULE a painkiller?
No. ORIGUS 50MG CAPSULE belongs to a group of medicines called Anthraquinones with mild anti-inflammatory and anti-catabolic properties. Contact your doctor before taking.
What is ORIGUS 50MG CAPSULE is used for?
ORIGUS 50MG CAPSULE is used for the symptomatic treatment of functional symptoms of osteoarthritis.
Who should avoid taking ORIGUS 50MG CAPSULE?
ORIGUS 50MG CAPSULE is avoided in patients with liver or kidney disease, colitis or crohn?s disease, partial or complete intestinal obstruction or abdominal pain with an unknown cause, rapidly progressive osteoarthritis of hip, allergic to ORIGUS 50MG CAPSULE or rhein, pregnant or lactating women, children and elderly patients. Consult your doctor before taking.
Can I take alcohol while using ORIGUS 50MG CAPSULE?
No. Do not take alcohol with ORIGUS 50MG CAPSULE as it may increases the risk of liver damage. Contact your doctor before taking.
What are the side effects of ORIGUS 50MG CAPSULE?
The most common side effects of taking ORIGUS 50MG CAPSULE are diarrhea, soft stools, pain in abdomen, frequent bowel movements, flatulence, skin rash, itching, and eczema.
How ORIGUS 50MG CAPSULE works?
ORIGUS 50MG CAPSULE belongs to proteoglycan synthesis stimulator which works by building cartilage (soft connective tissue around the joints) leading to joint repair. It also lowers pain and inflammation (swelling).
Does ORIGUS 50MG CAPSULE cause liver damage?
Yes. ORIGUS 50MG CAPSULE may increase the risk of liver injury. If you experience any unusual symptoms like tiredness, anorexia, yellowish discoloration of skin and white of eyes (jaundice), abdominal pain, nausea, vomiting, change in stool and urine colour, itchy skin. Stop taking ORIGUS 50MG CAPSULE and immediately consult your doctor.
REFERENCES
1. Pavelka K, Bruyere O, Cooper C, Kanis JA, Leeb BF, Maheu E, Martel-Pelletier J, Monfort J, Pelletier JP, Rizzoli R, Reginster JY. Uses and mechanism of ?Diacerein. National Institute of Health. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. February 2016. [Accessed on 7th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756045/
2. Solignac M. Les. Mechanism of action of Diacerein. National Institute of Health. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. May 2004. [Accessed on 7th May 2022] https://pubmed.ncbi.nlm.nih.gov/15226683/
3. Diacerein. European Medical Agency. [Accessed on 7th May 2022] https://www.ema.europa.eu/en/documents/referral/diacerein-article-31-referral-annex-iii_en.pdf
4. Diacerein. Mims.com. [Accessed on 7th May 2022] https://www.mims.com/india/drug/info/diacerein?type=full&mtype=generic#special-precautions
5. Israel pharmaceutical products. Diacerein. [Accessed on 7th May 2022] https://mohpublic.z6.web.core.windows.net/IsraelDrugs/ArcRishum01_1_158963216.pdf
6. Trima Israel Pharmaceutical Products Ltd. Diacerein. [Accessed on 7th May 2022] https://mohpublic.z6.web.core.windows.net/IsraelDrugs/ArcRishum01_6_164528016.pdf
7. Wellona pharma. Diacerein. [Accessed on 7th May 2022] https://wellonapharma.com/product/finished/diacerein-capsules
8. Diacerein. CDSCO. [Accessed on 6th May 2022] https://cdscoonline.gov.in/CDSCO/Drugs
USEFUL DIAGNOSTIC TESTS