Uses & Effectiveness Overview Palmitoylethanolamide (PEA) is a chemical made from fat. It is found naturally in foods such as egg yolks and peanuts, and in the human body. PEA can bind to cells in the body and reduce pain and swelling. PEA is used for different types of pain, fibromyalgia, osteoarthritis, multiple sclerosis (MS), carpal tunnel syndrome, autism, and many other conditions, but there is no good scientific evidence to support many of these uses. Palmitoylethanolamide (PEA) is a naturally occurring molecule that acts as a anti-inflammatory and analgesic compound in the body, providing relief from chronic pain and inflammation without causing any severe side effects. Side Effects When taken by mouth: PEA is possibly safe when used for up to 3 months. It?s usually well tolerated but might cause nausea in some people. There isn?t enough reliable information to know if PEA is safe to use for longer than 3 months. When applied to the skin: PEA is possibly safe when used for up to 28 days. Interactions We currently have no information for PALMITOYLETHANOLAMIDE (PEA) overview. Special Precautionsand Warnings When taken by mouth: PEA is possibly safe when used for up to 3 months. It?s usually well tolerated but might cause nausea in some people. There isn?t enough reliable information to know if PEA is safe to use for longer than 3 months. When applied to the skin: PEA is possibly safe when used for up to 28 days. Pregnancy and breast-feeding: There isn?t enough reliable information to know if PEA is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use. Children: Taking PEA by mouth for up to 3 months is possibly safe for children aged 4-17 years. Dosing PEA has most often been used by adults in doses of 300-1200 mg by mouth daily for 2-12 weeks. In children, it?s most often been used in doses of 600 mg by mouth daily for up to 3 months. PEA is also used in creams, lotions, and eye drops. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.