Panadol Extra Tab 500mg/65mg 100s works by inhibiting only COX enzyme activity, caffeine also inhibited COX-2 protein synthesis. These results are compatible with the view that the clinical activity of this drug is due to inhibition of COX.
Concerns

Frequently asked questions

Onset of action

Duration of Effect

Safe with Alchohol?

Is it habit forming?

Usage in pregnancy?

Usage while breast-feeding?

Dosage

Missed Dose

Overdose

References

wiki pedia –
Paracetamol and Caffeine [Internet].
Available from: https://en.wikipedia.org/wiki/Paracetamol
[cited 30/6/2020].

pubmed.org –
Caffeine and Paracetamol [Internet].
Available from: https://pubmed.ncbi.nlm.nih.gov/10963764/#:~:text=Whereas%20paracetamol%20inhibited%20only%20COX,due%20to%20inhibition%20of%20COX.
[cited 30/6/2020].