INTRODUCTION
PIRITEXYL LS JUNIOR SYRUP contains Ambroxol, Levosalbutamol and Guaifenesin?which belong to the group of medicines known as Mucolytics, Bronchodilators, and Expectorants. It is indicated for the treatment of productive cough with mucous for children (1-12years of age) associated with bronchospasm (spasm of lung muscle causing breathing difficulty).
The conditions can be bronchitis (inflammation of bronchial tubes which carries air from and to the lungs), bronchial asthma (inflammatory airway disease), wheezing, chest congestion, cough, etc.
PIRITEXYL LS JUNIOR SYRUP should be used with caution in children having liver, kidney or heart disease, high blood pressure, uncontrolled juvenile diabetes mellitus, hyperthyroidism (increased secretion of thyroid hormones), seizures or fits.
PIRITEXYL LS JUNIOR SYRUP can be used in children aged 1-12years, however, consult your doctor for advice before giving [GBNKRYWORD] to your child. PIRITEXYL LS JUNIOR SYRUP is not recommended for use in pregnant and breastfeeding women unless absolutely necessary. Consult with your doctor before taking it.
The most common side effects of taking PIRITEXYL LS JUNIOR SYRUP are increased heart rate, palpitations (sensation of fluttering heartbeat), indigestion, headache, vomiting, nausea (feeling sick), sweating, and muscle cramps. Contact your doctor if any of the symptoms does not improve or worsen.

USES OF PIRITEXYL LS JUNIOR SYRUP
Ambroxol is a mucolytic agent that promotes mucus clearance by decreasing its viscosity and increasing its volume. It facilitates expectoration and eases productive cough. Guaiphenesin is an expectorant which works by reducing the viscosity of lung secretions and aids in spitting out the mucous. Levosalbutamol is a beta-agonist that activates certain receptors called beta-2 adrenergic receptors in the lungs which facilitates smooth muscle relaxation and makes airways open for easy breathing and also acts as an anti-inflammatory agent. Together, they help patients with congestion, breathe freely and deeply.

HOW PIRITEXYL LS JUNIOR SYRUP WORKS
Ambroxol is a mucolytic agent that promotes mucus clearance by decreasing its viscosity and increasing its volume. It facilitates expectoration and eases productive cough. Guaiphenesin is an expectorant which works by reducing the viscosity of lung secretions and aids in spitting out the mucous. Levosalbutamol is a beta-agonist that activates certain receptors called beta-2 adrenergic receptors in the lungs which facilitates smooth muscle relaxation and makes airways open for easy breathing and also acts as an anti-inflammatory agent. Together, they help patients with congestion, breathe freely and deeply.

DIRECTIONS FOR USE
Give PIRITEXYL LS JUNIOR SYRUP to your child as directed by your physician. Shake well before use. Your doctor will decide the correct dose and duration for your child depending on the age, body weight and disease condition.

SIDE EFFECTS OF PIRITEXYL LS JUNIOR SYRUP

COMMON

Increased heart rate, palpitations (sensation of fluttering heartbeat)
Indigestion
Headache
Vomiting, nausea
Sweating
Muscle cramps
Diarrhoea
Heartburn
Bloating
Abdominal pain
Dry mouth or dry throat
Tremor

HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Give PIRITEXYL LS JUNIOR SYRUP to the child with, or just after a meal or snack. Let the child stick to simple meals and avoid oil-rich or spicy foods. Consult your doctor if there is no improvement in symptoms.
Headache:
Apply a hot or cold-water bag on your child?s head. Let the child take enough rest and relax. Massage on the scalp or head with mild pressure. Consult your doctor if there is no improvement in symptoms.
Dry mouth:
Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Make your child sip water at regular intervals of time. Consult your physician for advice.
Stomach pain:
Try and make your child rest and relax. Make your child eat slowly or try to keep frequent and smaller meals. Keep a heating pad on your child?s stomach. If the symptom does not improve or worsens, contact your doctor.

WARNING & PRECAUTIONS

PREGNANCY

PIRITEXYL LS JUNIOR SYRUP is not recommended for use in pregnant women unless absolutely necessary. PIRITEXYL LS JUNIOR SYRUP is intended for use only in children (1-12years). Consult your doctor before taking it.

BREASTFEEDING

PIRITEXYL LS JUNIOR SYRUP is not recommended for use in breastfeeding women unless absolutely necessary. PIRITEXYL LS JUNIOR SYRUP is intended for use only in children (1-12years). Consult your doctor before taking it.

KIDNEY

PIRITEXYL LS JUNIOR SYRUP should be used with caution in children having kidney diseases such as kidney failure. Consult your doctor before administering.

LIVER

PIRITEXYL LS JUNIOR SYRUP should be used with caution in children having a liver impairment. Consult your doctor before administering.

ALLERGY

Do not administer PIRITEXYL LS JUNIOR SYRUP if the child is allergic to Ambroxol, Levosalbutamol, Guaifenesin?or any other ingredients of this medicine.

HEART DISEASE

PIRITEXYL LS JUNIOR SYRUP should be used with caution in children having heart diseases. Consult your doctor before administering PIRITEXYL LS JUNIOR SYRUP.

OTHERS
Before administering PIRITEXYL LS JUNIOR SYRUP to your child, inform your doctor if your child:

Have uncontrolled juvenile diabetes mellitus
Have high blood pressure
Have hyperthyroidism (increased secretion of thyroid hormones)
Have seizures or fits

Use in paediatrics:
PIRITEXYL LS JUNIOR SYRUP is recommended for use in children aged 1-12years, however, consult your doctor for advice before giving [GBNKRYWORD]. Your doctor will decide the correct dose and duration for your child depending on the age, body weight and disease condition.
Use in geriatrics:
PIRITEXYL LS JUNIOR SYRUP is intended for use only in children (1-12years). Consult your doctor before taking it.

INTERACTIONS
A. Drug ? Drug interactions:
Before giving PIRITEXYL LS JUNIOR SYRUP to your child, inform your doctor if you are taking any of the following medicines:

Aminophylline (used to treat bronchospasm)
Corticosteroids such as prednisolone, hydrocortisone (used to treat inflammatory and autoimmune diseases)
Albuterol, levalbuterol (used to provide relief from breathlessness)
Epinephrine (medicine used for severe allergic reactions)
Diuretics such as furosemide, bumetanide, spironolactone (used to remove excess fluid or water from the body)
Digitalis (used to treat heart problems like congestive heart failure, angina, etc)
Monoamine oxidase inhibitors such as isocarboxazid,?phenelzine,?selegiline and tricyclic antidepressants such as amitriptyline, doxepin (used to treat depression)

Overdosage:
If the child or anyone else accidentally took too much of PIRITEXYL LS JUNIOR SYRUP, consult your doctor immediately or visit any nearby hospital.

SYNOPSIS

Drug
:
Ambroxol, Levosalbutamol, Guaifenesin

Pharmacological Category
:
Mucolytics, Bronchodilators, Expectorants

Therapeutic Indication
:
Productive cough with mucous

Dosage Forms
:
Syrup, Cough syrup, Oral Drops, Drops, Expectorant

MORE INFORMATION

Keep PIRITEXYL LS JUNIOR SYRUP out of reach of children
Store PIRITEXYL LS JUNIOR SYRUP at a temperature below 25?C

FAQs ABOUT PIRITEXYL LS JUNIOR SYRUP
What are the uses of PIRITEXYL LS JUNIOR SYRUP?
PIRITEXYL LS JUNIOR SYRUP is indicated for the treatment of productive cough with mucous for children (1-12years of age) associated with conditions like bronchospasm, bronchitis, bronchial asthma, tenacious or thickened mucus, wheezing, and chest congestion.
How much PIRITEXYL LS JUNIOR SYRUP should be given?
Your doctor will decide the correct dose and duration of PIRITEXYL LS JUNIOR SYRUP for your child depending on the age, body weight and disease condition. Administer the correct dose of PIRITEXYL LS JUNIOR SYRUP as per your child?s doctor instructions. Do not alter the dose on your own.
When PIRITEXYL LS JUNIOR SYRUP should be given with caution?
PIRITEXYL LS JUNIOR SYRUP should be used with caution in children having a liver impairment, kidney failure, high blood pressure, heart disease, uncontrolled juvenile diabetes mellitus, hyperthyroidism (increased secretion of thyroid hormones), seizures or fits.
Does PIRITEXYL LS JUNIOR SYRUP cause nausea or vomiting?
Yes, it may cause nausea or vomiting in some children. Ask the child to drink lots of fluids such as water or fruit juices so that the child is sufficiently hydrated. Do not administer any medicine to treat the condition. Consult your doctor if the symptom does not improve.
What should I do if I missed to administer a dose of PIRITEXYL LS JUNIOR SYRUP to child?
If you have missed a dose by chance, try to administer the PIRITEXYL LS JUNIOR SYRUP as soon as possible when you notice. However, if the time for the next dose is closer, skip the dosage and do not try to give the double dosage.

REFERENCES
1. KD. Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Eighth edition. 2013. Page ? 238.
2. Helmut H. Albrecht,?Peter V. Dicpinigaitis,?and?Eric P. Guenin, Role of guaifenesin in the management of chronic bronchitis and upper respiratory tract infections. NIH National Library of Medicine, National centre for biotechnology information. PubMed Central. December 2017. [Accessed 22nd October 2022].???????https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724298/
3. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Ambroxol. [Accessed on 22nd October 2022].?https://pubchem.ncbi.nlm.nih.gov/compound/Ambroxol#section=Mechanism-of-Action
4. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Levalbuterol. [Accessed on 22nd October 2022].?https://pubchem.ncbi.nlm.nih.gov/compound/Levalbuterol
5. Ahmad Kantar,?Ludger Klimek, Dorotheea Cazan,?Annette Sperl,?Ulrike Sent,?and?Margarida Mesquita. An overview of efficacy and safety of ambroxol for the treatment of acute and chronic respiratory diseases with a special regard to children. NIH National Library of Medicine, National centre for biotechnology information. PubMed Central. January 2020. [Accessed 22nd October 2022]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137760/
6. Mukesh Kumar Gupta?,?Meenu Singh. Evidence based review on levosalbutamol. NIH National Library of Medicine, National centre for biotechnology information. PubMed.gov. February 2007. [Accessed 22nd October 2022]?https://pubmed.ncbi.nlm.nih.gov/17337829/
7. Centaur Pharmaceuticals Pvt Ltd. Kofarest PD Drops 15ml. (Ambroxol + Levosalbutamol + Guaifenesin). [Accessed 22nd October 2022].?https://www.centaurpharma.com/downloads/2021/pediatrics/cough/KOfarest%20PD%20drops.pdf
8. Centaur Pharmaceuticals Pvt Ltd. KOFAREST LS JUNIOR Syrup 60ml. (Ambroxol + Levosalbutamol + Guaifenesin). [Revised on January 2021] [Accessed 22nd October 2022].?https://www.centaurpharma.com/downloads/peadiatrics/cough/Kofarest%20LS%20Junior%20syrup.pdf
9. Innovative Pharmaceuticals Pvt Ltd. Broncolite ? LS Drops (Ambroxol + Levosalbutamol + Guaifenesin). [Accessed 22nd October 2022].?https://www.innovativepharma.in/product/broncolite-ls-drops/
10. Leeford Healthcare. Amrox ? LX Drops. (Ambroxol + Levosalbutamol + Guaifenesin). [Accessed 22nd October 2022]?https://www.leeford.in/product/239/amrox-ls-drops

USEFUL DIAGNOSTIC TESTS

CT scan
MRI
Chest X-rays
Blood test

AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS

Last updated on 09 Feb 2023 | 10:40 AM(IST)

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