Prothiaden tablet 25 mg 10_10?s works by altering the levels of certain chemicals called neurotransmitters in the brain.
Side effects
Major & minor side effects for Prothiaden tablet 25 mg 10_10?s

Drowsiness

Shaking and trembling of arms and feet

Change in heart rate severe

Increase/decrease in libido

Constipation

Nausea or Vomiting

Loss of vision or blurred vision severe

Dry mouth

Excessive sweating

Slurred speech

Difficulty with passing urine

Burning, numbness, tingling in the arms and feet severe

Mental Confusion

Intestinal obstruction severe

Uses of Prothiaden tablet 25 mg 10_10?s
What is it prescribed for?

Depression
This medicine is used to relieve the symptoms of depression and other associated symptoms like sleep disturbances, loss of appetite etc.

Concerns

Frequently asked questions

Onset of action
The antidepressant effect of this medicine is cumulative and can be observed within 3-4 weeks of administration. However, the sleep-inducing effect can be observed within an hour.

Duration of Effect
The effect of this medicine can last for more than 6 weeks. However, it is subject to vary on an individual basis.

Safe with Alchohol?
Avoid the consumption of alcohol while taking this medicine due to an increase in the risk of drowsiness, confusion, impaired judgment etc. It is advised that you do not perform tasks that require a high level of mental alertness like driving a vehicle or operating machinery after taking this medicine and alcohol together. Contact your doctor immediately if you experience excessive drowsiness.

Is it habit forming?
No habit forming tendencies were reported.

Usage in pregnancy?
This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor may prescribe a suitable alternative that is relatively safer to use.

Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor may prescribe a suitable alternative that is safer to use. If this medicine is prescribed, close monitoring of the infant for any undesired effects is necessary.

When not to use?

Allergy
This medicine is not recommended for use if you have a known allergy to Prothiaden tablet 25 mg 10_10?s or any other ingredient present with it.

Monoamine oxidase inhibitors (MAOI)
This medicine is not recommended for use while you are taking any medicine belonging to the Monoamine oxidase inhibitors (MAOI) drug class due to an increase in the risk of seizures, fever, hallucinations, and rarely death. Some of the most commonly used medicines in this class are Selegiline, Isocarboxazid, Phenelzine etc. The time gap between the consumption of these medicines should be a minimum of 14 days.

Heart Attack
This medicine is not recommended for use if you are recovering from a heart attack suffered in the recent times.

Manic phase of bipolar disorder
This medicine is not recommended for use while a patient is experiencing manic episodes of Bipolar disorder.

Liver disease
This medicine is not recommended for use in patients having an impairment of the normal liver function.

Warnings

Warnings for special population

Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor may prescribe a suitable alternative that is relatively safer to use.

Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor may prescribe a suitable alternative that is safer to use. If this medicine is prescribed, close monitoring of the infant for any undesired effects is necessary.

General Warnings

Sedation
Use of this medicine can cause moderate to severe sedation and impairment of physical abilities. You should avoid work that requires a high level of mental alertness while using this medicine.

Fall in blood pressure
Use of this medicine may cause a fall in the blood pressure, and hence, caution is advised. It may also cause dizziness and fainting if you get up from a sitting position suddenly.

Liver disease
This medicine should be used with caution in patients having a liver disease or an impairment of normal liver function due to the potential for severe adverse effects in such patients.

Bipolar disorder
This medicine should be used with extreme caution in patients suffering from bipolar disorder. Symptoms of mania and psychoses can worsen upon using this medicine. Consult your doctor and report the incidence of bipolar disease associated mania before receiving this medicine.

Prostate gland disorder
This medicine should be used with caution in patients with a disorder of the prostate gland. The symptoms of the disease might worsen upon using this medicine.

Heart rhythm disorder
This medicine should be used with caution in patients suffering from conduction disorders of the heart. Contact your doctor immediately if the symptoms of your heart condition worsen after taking this medicine.

Suicidal thoughts
Use of this medicine is reported to provoke suicidal thoughts and increased suicidal tendencies, especially in young patients. Report any such incidence to the doctor on priority so that counseling and monitoring of progress can be performed at regular intervals.

Withdrawal symptoms
Use of this medicine should not be discontinued abruptly. On abrupt stopping of treatment, you may experience withdrawal symptoms, especially if you have been using a high dose for a long duration. Do not stop the use of this medicine without consulting your doctor.

Other medicines
Report the use of all other medicines including herbs and supplements to the doctor. This medicine has the potential to interact with many other medicines and may cause harmful side effects.

Pediatric use
This medicine is not recommended for use in children as the safety and efficacy are not established.

Use in the elderly
This medicine should be used with caution in the elderly and bedridden patients. Appropriate dose adjustments should be done to rule out the risk of adverse effects.

Kidney disease
This medicine should be used with caution in patients having an impairment of the normal kidney function.

Surgery
Use of this medicine is not recommended if you are planning to undergo a surgery in the near future. Consult your doctor in this regard so that this medicine can be discontinued properly.

Dosage

Missed Dose
Take the missed dose as soon as you remember. However, if it is almost the time for the next scheduled dose, then the missed dose should be skipped. Do not double the dose to make up for the missed one.

Overdose
Contact the doctor immediately if an overdose is suspected. Symptoms of overdose may include a change in pulse rates, severe drowsiness, confusion, vomiting, hallucinations, convulsions, and fainting. Immediate medical intervention may be required if the overdose symptoms are severe.

Interactions
Interaction with Medicines

Cisapride moderate

Flavoxate severe

Hydrochlorothiazide severe

Selegiline severe

Chlorpromazine severe

Phenobarbital moderate

Diazepam moderate

Guanethidine moderate

Ephedrine moderate

Disease interactions

severe
This medicine should be used with caution in patients suffering from heart disease like heart failure, stroke, heart block etc. Symptoms like a fall in blood pressure, rapid change in pulse, dizziness, and other associated complications should be reported to the doctor on priority. It is advised that you do not take this medicine if you have recently suffered a heart attack.

moderate
This medicine should be used with extreme caution in patients who are suffering from glaucoma or who are suspected of having this condition. Use of this medicine may worsen the symptoms of angle closure glaucoma.

severe
This medicine should be used with extreme caution in patients suffering from bipolar disorder. Use of this medicine is not recommended if the patient is experiencing manic episodes.

General Instructions

Take This medicine exactly as instructed by the doctor. Ensure that the right quantity of medicine is consumed for the prescribed duration only. Initial use may worsen the symptoms of depression and it may take up to 20-30 days for any improvement to happen. Usage of this medicine should not be stopped abruptly since this may cause severe withdrawal symptoms.

Other details

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

References

drugbank –
Dosulepin [Internet].
Available from: https://go.drugbank.com/drugs/DB09167
[cited 1/11/2021].
2021