Rapact 10mg Tablet 10?S Allschoolabs -

Specification

INTRODUCTION
RAPACT 10MG contains Everolimus is an antineoplastic chemotherapy drug. This medication is classified as an mTOR kinase inhibitor. It reduces the blood supply to the tumour and slows down the growth and spread of cancer cells. This medicine is used to treat people with advanced kidney cancer and subependymal giant cell astrocytoma (SEGA) by slowing the growth and spread of tumour cells. It is also used as Prophylaxis of organ rejection?in kidney and liver transplant.
Everolimus is a targeted therapy which works by targeting specific to the cancer cells, thereby decreasing side effects caused by unwanted damage to the healthy cells. It is a kinase inhibitor that inhibits mTor kinase. mTor kinase is an enzyme required for cell growth and survival and by blocking this enzyme, the medication prevents cell division and, in turn, tumor growth. The medication can also interrupt the development of blood vessels (angiogenesis) that supply with nutrients, which tumor need to grow.
Always take this medicine as instructed by your doctor.Avoid grapefruit juice while taking this medicine. Swallow this medicine whole and do not chew or crush it.?RAPACT 10MG can develop mouth ulcers and sores. Your doctor might prescribe with a mouthwash, gel or other products. Before taking this medicine, consult your doctor if you have any ongoing medication for any underlying disease.?Do not drive or handle any machines while taking this medicine may cause tiredness. It is not to be used in children or adolescents below 18 years of age. The most common side effects are chills (signs of infection),?fever, coughing and wheezing,?excessive thirst, high or low urine output, increased appetite with weight loss, tiredness and bleeding.
USES OF RAPACT 10MG

Breast cancer

Neuroendocrine tumors (NET)

Renal cell carcinoma (RCC)

HOW RAPACT 10MG WORKS
RAPACT 10MG works by inhibiting mTor kinase, an enzyme required for cell growth and survival. By blocking this enzyme, it prevents cell division and, in turn, tumor growth. This medicine can also interrupt the development of blood vessels (angiogenesis) that supply with nutrients, which tumor need to grow.
DIRECTIONS FOR USE
Always take RAPACT 10MG?exactly as your doctor has directed you. Avoid grapefruit juice while taking this medicine. Swallow this medicine whole and do not chew or crush it.
SIDE EFFECTS OF RAPACT 10MG

SERIOUS

Difficulty breathing or swallowing

Swelling of the face, lips, tongue or throat

Severe itching of the skin

COMMON

Increased temperature

Chills (signs of infection)

Fever, coughing and wheezing

Excessive thirst

High or low urine output

Increased appetite with weight loss

Tiredness

Bleeding

RARE

Shortness of breath or rapid breath

HOW TO MANAGE SIDE EFFECTS
Cough:
Drink sufficient quantity of fluids which helps to thin the mucus in your throat. Suck on cough drops or hard candies.
WARNING & PRECAUTIONS

PREGNANCY
RAPACT 10MG should be used with caution in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
RAPACT 10MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or handle any machines while taking this medicine may cause tiredness.
KIDNEY
RAPACT 10MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
RAPACT 10MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic (hypersensitive) to Everolimus or any of the other ingredients in this medicine.
OTHERS
Inform your doctor if you have:
Diabetes (high level of sugar in your blood)

High cholesterol

Had recent major surgery, or if you still have an unhealed wound following surgery

An infection

Previously had hepatitis B

INTERACTIONS
Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:
Ketoconazole, itraconazole, voriconazole or fluconazole (used to treat fungal infections)

Clarithromycin, telithromycin and erythromycin (used to treat bacterial infections)

Ritonavir, efavirenz and nevirapine (used to treat HIV infection/AIDS)

Verapamil or diltiazem (used to treat heart conditions or high blood pressure)

Dronedarone (used to regulate heartbeat)

Ciclosporin

Imatinib (inhibits the growth of abnormal cells)

Ramipril

Rifampicin (used to treat tuberculosis)

Dexamethasone

Phenytoin, carbamazepine or phenobarbital

SYNOPSIS

Drug :?? Everolimus

Pharmacological Category :?? Antineoplastic Agent,?Immunosuppressant Agent

Therapeutic Indication :?? Breast cancer,?Neuroendocrine tumors (Carcinoid tumors),?Renal cell carcinoma,?Renal and Liver transplantation

Dosage Forms :?? Tablet

MORE INFORMATION
Store below 20-25?C and keep out of reach of children.
FAQs ABOUT RAPACT 10MG
What should I avoid while taking RAPACT 10MG?
Avoid grapefruit or grapefruit juice while taking this medicine.?
How long can you take RAPACT 10MG?
There is no definite duration of treatment with this medicine. It is continued till clinical benefit is seen or unacceptable toxicity or side effects occur.
How is RAPACT 10MG administered?
It is taken once or twice daily. The medicine should always either be taken with food or always be taken without food. It should be swallowed whole with water and should not be crushed or chewed.
REFERENCES
1. KD Tripathi MD. Miscellaneous drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page ? 882.
2. Krensky AM, Bennett WM, Vincenti F. Immunosuppressants, Tolerogens, and Immunostimulants. Goodman & Gilman?s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. Page ? 1013.
3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page ? 526.
4. Novartis Pharmaceuticals UK Ltd. Electronic Medicines Compendium (EMC); [Revised Feb 2020] [Accessed Oct 7, 2020] https://www.medicines.org.uk/emc/files/pil.7732.pdf
5. Novartis Pharmaceuticals Corporation. 2009; U.S. Food & Drug Administration; [Revised Oct 2010] [Accessed Oct 7, 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022334s6lbl.pdf
USEFUL DIAGNOSTIC TESTS

Breast Cancer (CA 15.3/ ER/ PR)

Carcino Embryonic Antigen

Complete Blood Count

PRODUCT DETAILS

Net Qty

1 N

Item Weight

17.5 g

Ingredient

EVEROLIMUS 10MG

Hsn Code

30049099