Specification

INTRODUCTION
RESPICURE M is a combination of Levocetirizine and Montelukast which belongs to theroup of medicines called H1 receptor antagonists and Leukotriene receptor antagonists respectively. RESPICURE M is indicated for the treatment and prevention of allergic rhinitis, chronic idiopathic urticaria (allergic skin reaction with red raised itchy bumps on skin) and bronchial asthma in adults and in adolescents (aged 15 years or above).
Allergic rhinitis (also known as hay fever) is a heterogeneous?disorder characterized by inflammation of the inner lining of nose accompanied by?nasal decongestion, repeated sneezing, wheezing, or a red, watery, and itchy eyes. It is usually caused by allergens such as pollens, dusts, mould, or flakes of skin from certain animals and can occur seasonally or year-round. Bronchial asthma is a long-term medical condition in which the path of the airways becomes inflamed, narrow, and swollen. Symptoms include coughing, wheezing, and chest tightness.
Levocetirizine is a H1 receptor antagonist that antagonizes the effects of histamine (a substance that cause allergic reaction) on the surface of the cells and montelukast is a leukotriene receptor antagonist that blocks the actions of leukotrienes responsible for causing narrowing and inflammation of the airways, thus leading to relaxation of smooth muscles in the lungs and reduction in swelling and/or inflammation of the airways.
RESPICURE M is not recommended for use in patients having severe kidney impairment. Consult your doctor before taking. Avoid consumption of alcohol while taking RESPICURE M as it may reduce your alertness and cause impaired performance in activities requiring mental concentration. RESPICURE M may cause certain unpleasant neuropsychiatric events (such as anxiety, depression, nightmares, hallucinations, or even suicidal thoughts) in some individuals. Contact your doctor immediately if you or anyone else experience such events.
RESPICURE M should be taken during pregnancy only if clearly advised by your doctor and not recommended for use in breast-feeding women. RESPICURE M should be used with caution in elderly patients (above 65 years of age) and not recommended for use in children and adolescents (less than 15 years of age). The most common side effects of taking RESPICURE M are upper respiratory tract infection, fever, cough, inflammation of the pharynx, dryness of mouth, headache, and somnolence. Consult your doctor if any of the symptoms worsen.
USES OF RESPICURE M

To treat and prevent allergic rhinitis, chronic idiopathic urticaria and bronchial asthma in adults and in adolescents (aged 15 years or above)

HOW RESPICURE M WORKS
RESPICURE M provides relief from the symptoms of allergic rhinitis, asthma and urticaria where levocetirizine acts by blocking the actions of histamines (a substance that cause allergic reaction), at the H1 receptors present on the surface of cells and montelukast acts by blocking the action of leukotrienes D4 (an inflammatory molecule causing narrowing and swelling of the airways) in the lungs, thus causing relaxation of smooth muscle, reduction in swelling and/or inflammation of the airways and a marked decrease in the onset of allergic reactions.
DIRECTIONS FOR USE
Take RESPICURE M as advised by your physician. Swallow RESPICURE M with alass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF RESPICURE M

COMMON

Upper respiratory tract infection

Cough, cold, fever or flu-like symptoms

Headache and tiredness

Sleepiness

Nausea, vomiting, dry mouth, thirst, stomach pain, diarrhea

Otitis media (inflammation or infection of the ears)

Skin rash

UNCOMMON

Changes in behavior and mood (anxiety, nightmares, irritability, sleepwalking)

Dizziness, tingling and prickling sensation or numbness in the body

Indigestion

Bleeding in the nose

Itching, bruising

Joint or muscle pain

Muscle cramps, weakness

Urinary incontinence in children

Swelling

RARE

Attention disturbance, memory impairment, uncontrolled muscle movements
Stop taking RESPICURE M and contact your doctor immediately if you experience any of the following side effects:
Severe allergic reactions (such as swelling of the face, lips, tongue and/or throat, difficulty in breathing or swallowing, mood changes, agitation, aggressive behavior or hostility, depression, seizure)

Increased bleeding tendency, tremor (shaking), palpitations (fast heartrate)

Flu-like symptoms, numbness of arms and legs, worsening of pulmonary symptoms and/or rash (Churg-Strauss Syndrome)

Decreased blood platelet count

Neuropsychiatric changes (such as disorientation, hallucinations)

Thoughts of harming or killing yourself (suicidal ideation)

Inflammation (swelling) of the lungs

Erythema multiforme (a severe skin reactions)

Hepatitis (inflammation of the liver)

HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Try to take RESPICURE M with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did not improve.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Headache: ?
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Dizziness:
Try to rest and relax.et enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve.
WARNING & PRECAUTIONS

PREGNANCY
RESPICURE M should be used during pregnancy only if considered clearly necessary. Consult your doctor before taking RESPICURE M.
BREASTFEEDING
RESPICURE M is not recommended for use in breastfeeding women. Consult your doctor before taking RESPICURE M.?
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience drowsiness, tiredness, or sleepiness. Consult your doctor before taking RESPICURE M.?
ALCOHOL
Avoid consumption of alcohol while taking RESPICURE M as it may reduce alertness and impairment of performance. Consult your doctor before taking RESPICURE M.?
KIDNEY
RESPICURE M is not recommended for use in patients with severe kidney impairment. It should be taken with extreme caution in patients with mild to moderate kidney disease. Consult your doctor for before taking RESPICURE M.
LIVER
RESPICURE M should be taken with caution in patients with liver disease. Consult your doctor before taking RESPICURE M.
ALLERGY
Do not take RESPICURE M if you are allergic to Montelukast or Levocetirizine or Cetirizine.
OTHERS
RESPICURE M is not recommended for use if you:
Havealactose intolerance (inherited condition in which the body cannot convertalactose tolucose)

Have Lapp lactase deficiency (deficiency of the enzyme lactase in the body)

Havelucose-galactose malabsorption

Have phenylketonuria (release of phenylalanine in urine)

Have acute asthma attacks
Before taking RESPICURE M, inform your physician if you:
Have or at risk of having epilepsy

Have sensitivity to aspirin or other NSAIDs

Have any predisposing factors of urinary retention (Ex. spinal cord lesion, prostatic hyperplasia)

Are scheduled for allergy testing
Use in pediatrics:
RESPICURE M is strictly not recommended for use in children aged below 15 years. Consult your doctor before taking RESPICURE M.
Use ineriatrics:
RESPICURE M should be used with caution in elderly patients (aged 65 years or above). Proper dose titrations and careful monitoring of kidney functions are required in such patients. Consult your doctor before taking RESPICURE M.
INTERACTIONS
A. Drug-Drug interactions:
Before taking RESPICURE M inform to your doctor, if you are taking any of these medicines:
Gemfibrozil?(used to control high blood cholesterol levels)

Other CNS depressants such as phenobarbital or phenytoin (used to treat epilepsy)

Rifampicin (used to treat tuberculosis)

Ritonavir (used to treat viral infections)

Theophylline (used to treat asthma)
Overdosage:
If you or anyone else take too much of RESPICURE M, contact your doctor immediately oro to a hospital straight away. Overdosage symptoms of RESPICURE M include stomach pain, thirst, sleepiness, drowsiness, headache, vomiting, psychomotor hyperactivity, agitation, and restlessness.
SYNOPSIS

Drug :??
Levocetirizine, Montelukast
Pharmacological Category :??
H1 receptor antagonist, Leukotriene receptor antagonist
Therapeutic Indication :??
Allergic rhinitis, Bronchial asthma, Chronic idiopathic urticaria
Dosage Forms :??
Tablet, Capsule, Dispersible tablet, Syrup, Suspension
MORE INFORMATION

Keep RESPICURE M out of reach of children

Store RESPICURE M at room temperature

FAQs ABOUT RESPICURE M
How long does it take for RESPICURE M to provide relief from symptoms?
Following oral administration of RESPICURE M, it is believed to provide relief from the symptoms of allergy and asthma within 30 minutes to an hour. Please note that the onset of action varies from product to product and consult your doctor if you have any queries.
Can RESPICURE M be used to treat acute asthma attacks?
No. RESPICURE M is used only to prevent asthma attack. It should not be used on an asthma attack that has been started already. Contact your doctor oro to the nearby hospital to avoid exacerbation of the attack.? ?
Can RESPICURE M be used in infants?
No. RESPICURE M is only meant to be used in adults and in adolescents (aged 15 years or above). RESPICURE M is strictly not recommended for use in children aged between 6 months to 11 years of age without consulting your doctor. ??
Can RESPICURE M make you feel sleepy?
Yes. RESPICURE M may make you feel sleepy or drowsy. Try to rest and relax.et enough sleep. Avoid driving or operating any tools or machines while you are feeling sleepy. Avoid alcohol intake, as it could aggravate your existing condition. Consult your doctor if the symptom did not improve.
Can I drink alcohol while taking RESPICURE M?
Avoid consumption of alcohol while taking RESPICURE M as it may reduce your alertness and cause impaired performance in activities requiring mental concentration. Consult your doctor before taking RESPICURE M if you are alcoholic.
What to do If I forget to take RESPICURE M?
You should take RESPICURE M immediately when you remember. If it is time for your next dose skip the dose and follow your regular dose schedule. Do not double the dose of RESPICURE M to match up your missed dose.
REFERENCES
1. KD. Tripathi. Histamines and Antihistamines & Drugs for cough and bronchial asthma. Essentials of medical pharmacology. Seventh edition. 2013. Page ? 166-168 & 228-229.
2. Peter J. Barnes. Pulmonary pharmacology. Randal A. Skidgel, Allen P. Kaplan and Ervin. Erdos. Histamine, Bradykinin, and their antagonists.oodman &ilman?s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page ? 918-923 & 1052-1054.
3.erald. Briggs and Roger K. Freeman. L & M. A referenceuide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page ? 2219-2220 & 2629-2632.
4.?Sheila Jacobs. Montelukast Plus Levocetirizine vs Monotherapy in Asthma, Allergic Rhinitis. Pulmonology adviser. [Revised in October 2018]. [Accessed on 13th October 2021]?https://www.pulmonologyadvisor.com/home/meetings/chest-2018/montelukast-plus-levocetirizine-vs-monotherapy-in-asthma-allergic-rhinitis/#:~:text=Perennial Allergic Rhinitis-,Montelukast plus levocetirizine was well tolerated, with a safety profile,perennial allergic rhinitis and asthma.
5.?S M Adsule,?D Misra. Long term treatment with montelukast and levocetirizine combination in persistent allergic rhinitis: review of recent evidence. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. [Revised in June 2010] [Accessed on13th October 2021]?https://pubmed.ncbi.nlm.nih.gov/21121394/
6.?Mi-Kyeong Kim,?Sook Young Lee,?Hae-Sim Park,?Ho Joo Yoon,?Sang-Ha Kim,?Young Joo Cho,?Kwang-Ha Yoo,?Soo-Keol Lee,?Hee-Kyoo Kim,?Jung-Won Park,?Heung-Woo Park,?Jin-Hong Chung,?Byoung Whui Choi,?Byung-Jae Lee,?Yoon-Seok Chang,?Eun-Jung Jo,?Sang-Yeub Lee,?You Sook Cho,?Young-Koo Jee,?Jong-Myung Lee,?Jina Jung,?Choon-Sik Park. A Randomized, Multicenter, Double-blind, Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients with Asthma and Allergic Rhinitis. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. [Revised in July 2018] [Accessed on 13th October 2021]?https://pubmed.ncbi.nlm.nih.gov/29945738/
7.?E Nettis,?G F Calogiuri,?E Di Leo,?F Cardinale,?L Macchia,?A Ferrannini,?and?A Vacca. Once daily levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria. NCBI; PMC US National Library of Medicine, National Institute of Health. 2009. [Accessed on 13th October 2021]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048603/
8.?Paulina Korczy?ska-Krawczyk, Iabela Kuprys-Lipi?ska,?Maciej Kupczyk, Malgorzata Wagrowska-Danilewicz,?Janusz Szemraj,?Wojciech Bienias,?Joanna Narbutt,?Janusz Smigielski,?and?Piotr Kuna. The effect of levocetirizine and montelukast on clinical symptoms, serum level and skin expression of COX-1 and COX-2 enzymes in patients suffering from chronic autoimmune urticaria ? a pilot study. NCBI; PMC US National Library of Medicine, National Institute of Health. [Revised in February 2020]. [Accessed on 13th October 2021]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247068/
9. Cipla Ltd. MONTAIR LC & MONTAIR LC KID DT / Syrup?(Montelukast sodium Levocetirizine dihydrochloride). Ciplamed.com. [Revised in December 2020]. [Accessed on 13th October 2021]?https://www.ciplamed.com/content/montair-lc-montair-lc-kid-dt-syrup
10. Cipla Ltd. RID-AR Tablets & RID-AR KID DT/Syrup?(Montelukast sodium Levocetirizine dihydrochloride). Ciplamed.com. [Revised in November 2013]. [Accessed on 13th October 2021]?https://www.ciplamed.com/content/rid-ar-tablets-rid-ar-kid-dtsyrup
11. TORRENT PHARMACEUTICALS LTD. LEZYNCET-M. Torrentian.com. April 2020. [Accessed on 13th October 2021]?https://www.torrentian.com/pisheet/Upload/PI_Sheet/2916.pdf
12. RND Laboratories. Laboratories division. RND KAST-L10 TABLETS. [Accessed on 13th October 2021]?http://www.rndlaboratories.com/laboratories_division.php
13.lenmark Pharmaceuticals s.r.o., Tillomed Laboratories Ltd. Andlenmark Pharmaceuticals Europe Limited. Electronic Medicines Compendium (EMC). [Revised in November 2019] [Accessed on 13th October 2021]?https://www.medicines.org.uk/emc/files/pil.9917.pdf
14. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 13th October 2021]?https://www.medicines.org.uk/emc/files/pil.1243.pdf
USEFUL DIAGNOSTIC TESTS

Absolute Eosinophil Count

Complete Blood Count

VIDEOS

Levocetirizine Montelukast TABLET ? Drug Information
Levocetirizine Montelukast TABLET : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
PRODUCT DETAILS

Net Qty

1 N

Item Weight

17.5

Ingredient

MONTELUKAST 10MG LEVOCETIRIZINE 5MG

Hsn Code

30049099

Show more

Additional information

Weight
17.5 g

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